Conserved Protein Domain Family
FeeA_FeeB_like

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cd01836: FeeA_FeeB_like 
SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it turn are loaded onto the acyl carrier protein FeeL. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.
Statistics
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PSSM-Id: 238874
Aligned: 30 rows
Threshold Bit Score: 108.507
Created: 20-Aug-2004
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:by similarity to other members of this super-family
  • Comment:the active site resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases
  • Citation:PMID 7773790

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #                                               #                     
CAB89450     71 PPLRLMMLGDSTAAGQGVhrag-----qtpgALLASGLaavae----rpvrlGSVAQPGACSDDLdrqvalvl------- 134 Streptomyces coe...
EAM75366      5 APLRLALLGDSLAAGVGAadardtpgplltaDLVAAGIpa----------ehRVFAVSGARSTALagqvaa--------- 65  Kineococcus radi...
ZP_01431579  74 PAVTMVILGDSCAAGYGVhrrr-----etpgALLATGVsrrlh----rpvrlHRFAVVGALSAVLryqvea--------- 135 Salinispora trop...
ZP_00659543  63 APLDLLLLGDSIAAGLGAerpk-----etlgGRLARALaretg----ravrlRTAARVGSESSTLaaqlagl-------- 125 Nocardioides sp....
ZP_01431580  63 SPLRLVLLGDSSALGVGVsrla-----etvgGQLAYLLaegpag---qlvhlSSVGVSGSRSADLatqvara-------- 126 Salinispora trop...
NP_335547    74 FDVHLMIFGDSTATGYGCasae-----evpgVLIARGLaeqtg----krirlSTKAIVGATSKGVcgqvdam-------- 136 Mycobacterium tu...
YP_713494    61 PPFTLGILGDSSAQGTGVhdyd-----dtlgGWLARALgdgvgdgggrhvrvVSAARDGARAEHLaaqvar--------- 126 Frankia alni ACN14a
ZP_01102967  47 PARKILVVGDSTAVGTGAaa---------peDSIAGRIaedfs-----rtavMNFAEDGVLTRAVpgqlqq--------- 103 Congregibacter l...
ZP_01131253  35 DPDRILLLGPGKATGYGVsthe-----lglgGHLARNLaalts----rgcgvDIVADPSMSAADAgvview--------- 96  marine actinobac...
ZP_00378527  59 DSAALAIIGDSWLCGIDVddpa-----qappNLIARGLgrilg----ttvrvQSTARPSALSEDLprqvdeilrsawlsr 129 Brevibacterium l...
Feature 1                          #                                                            
CAB89450    135 ---aepdrvpDICVIMVGANDVThrmPATRSVRHLSSAVRRLrt-aGAEVVVGTCPDLgtier---vrqpLRWLARRASR 207 Streptomyces coe...
EAM75366     66 -----agtwpQVAVVVVGANDLThavPVAQAVAELAAALTALra-tGAEAVLVPAPDLsvvah---vppaLREFARTASA 136 Kineococcus radi...
ZP_01431579 136 ----alearpDVAVILIGGNDVTnrtPPAVAVRYLIEAVTTLra-aGCAVVVGTCPDLgairp---iqppLRWLARRWSR 207 Salinispora trop...
ZP_00659543 126 ----pptyrpDVAVIVVGGNDVThrvPVAESVKHLEEAVHGLrd-lGAGVVVGTCPDLgalrp---vpqpLRALGSRASR 197 Nocardioides sp....
ZP_01431580 127 ----llgerpDVAVILIGANDATtlrRSADAAACLGATVRRLre-aRVEVVVGTCPDLgavra---iappLRHLVGWSGR 198 Salinispora trop...
NP_335547   137 ---fvvgpppDAAVIMIGANDITalnGIGPSAQRLADCVRRLrt-rGAVVVVGTCPDLgvita---ipqpLRALAHTRGV 209 Mycobacterium tu...
YP_713494   127 ----vapaapDLAVISIGVNDIRnrtSPAAAARHLAGAVTDLrr-gGARVIVGTTPDLsvisa---vrspLREVLWLLGL 198 Frankia alni ACN14a
ZP_01102967 104 ----appgsyDMVLIQVGGNDALrftGSETLEAAIEKSLDAAaa-lSQNILLVSVGDLgeara---apwpLSLLLSHRSR 175 Congregibacter l...
ZP_01131253  97 ----srlerfDALVLTLGGGEVLrmrSIFAWRRDVTTVLDTIee-rGGGVLQTFVLGIapvdellslpgpLLRIVNANAV 171 marine actinobac...
ZP_00378527 130 qlseswtaqrRFAIISIGTGDIIhpiHGTIGIPVLTQAINRLqregRYTVFVLVCPNLgglpg---lrdpLKTSLRRTSR 206 Brevibacterium l...
Feature 1                                                  #  #                   
CAB89450    208 QLAAAQTIGAVeqggrtVSLGDLLgpefaq-----nprelFGPDNYHPSAEGYATAAMAVLPSVCA 268 Streptomyces coelicolor A3(2)
EAM75366    137 QLRTAQTRAAAaagvavADTSAAAavfar-------dpsmFSPDRFHPSAAGYRVIAADVAPLVRA 195 Kineococcus radiotolerans SRS3...
ZP_01431579 208 QLAAAQTVAVVeaggatVSLGDLLgprfta-----eparmFAWDRFHPSAEGYAMAAAALLPTVLS 268 Salinispora tropica CNB-440
ZP_00659543 198 QLALAQEAVAVaagahaVSLARVVgpffit-----npdemFSLDRFHPSALGYKRTAKAMLPSILA 258 Nocardioides sp. JS614
ZP_01431580 199 RMARAQTLAVLtaggtvVDLATEAgpvfr------advgtFCHDGFHPSADGYRVWAHALFPAVAA 258 Salinispora tropica CNB-440
NP_335547   210 RLARAQTAAVKaaggvpVPLGHLLapkfra-----mpelmFSADRYHPSAPAYALAADLLFLALRD 270 Mycobacterium tuberculosis CDC...
YP_713494   199 LLERAQTPAVAaaggtpVTLRTAVsrrfg------adptlFAPDGLHASARGNALIGSHLLAAYRA 258 Frankia alni ACN14a
ZP_01102967 176 LVRDVFADAARrr---dVRFLDLLalseegspfednsekyYARDGLHPSSAGYEVWYENLRASVPL 238 Congregibacter litoralis KT71
ZP_01131253 172 TLNEISEELCAtr--ssVTFVPVTt--------------pSGGPRVALESHTYAHWARELAPAIAS 221 marine actinobacterium PHSC20C1
ZP_00378527 207 VLAGSQWLAALsa---rATPLRATgslsgt-----trrslLNESGRFPSTLGFAQVSSTVLAAIAD 264 Brevibacterium linens BL2

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