1NI9,1FTA,1INP,1DK4,1QGX,2HHM


Conserved Protein Domain Family
FIG
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cd01636: FIG 
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FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in gluconeogenesis. Inositol-monophosphatases and inositol polyphosphatases play vital roles in eukaryotic signalling, as they participate in metabolizing the messenger molecule Inositol-1,4,5-triphosphate. Many of these enzymes are inhibited by Li+.
Links
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Statistics
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PSSM-Id: 238814
Aligned: 10 rows
Threshold Bit Score: 123.657
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active site
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2HHM: binds sulfate and an inhibitory lanthanide, which establish the location of the active site
  • Citation:PMID 1332026
  • Structure:IQGX_A binds AMP, phosphate, and magnesium
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                        #                        ##    
1NI9_A        8 AIEFSRVTESAALAGykwlg----------------------rgdknTADGAAVNAMRIMLnqvn--idgTIVIGEgeid 63  Escherichia coli
1FTA_A       34 LNSLCTAVKAISSAVrkagiahlygia---------gstnvtgdqvkKLDVLSNDLVMNMLkssf--atcVLVSEEdkha 102 human
1INP          5 LQELLRVSEKAANIAracrqqetlfqllieekkegeknkkfavdfktLADVLVQEVIKENMenkfpglgkKIFGEEsnel 84  cow
1DK4_A        4 DEIGKNIAKEIEKEIlpyfgrkdksyv---------vgtspsgdeteIFDKISEDIALKYLksl----nvNIVSEElgvi 70  Methanocaldococc...
1QGX_A        7 LLVATQAVRKASLLTkriqsevishkds-------ttitkndnspvtTGDYAAQTIIINAIksnf--pddKVVGEEsssg 77  baker's yeast
2HHM_A        8 MDYAVTLARQAGEVVceaiknemnvm-----------lksspvdlvtATDQKVEKMLISSIkeky--pshSFIGEEsvaa 74  human
NP_376435     2 REVLVKITKEIISFLyeekdkqgidk----------iigkhgndvtrVIDKKSEELIFDRLnhsg--ykfMFVSEEagvv 69  Sulfolobus tokod...
P22255        2 LDQVCQLARNAGDAImqvydgtkpmd----------vvskadnspvtAADIAAHTVIMDGLrtlt--pdvPVLSEEdppg 69  Escherichia coli
NP_946257    53 AAFIGRLATSSGDTIlpffrtsltidn---------kqpgrdfdpvtEADRAAEAVMRRLIkasf--pqhGIIGEEfgne 121 Rhodopseudomonas...
ZP_00206943   9 LTLALEVAAEAGRLAldffarreslav---------eakaspqdivsRADREVETLIRARIaarf--pddGVLGEEhgae 77  Rhodobacter spha...

Feature 1                                                                           #####       
1NI9_A       64 eapmlyig---------------------------------------------ekvgtgrgdavdIAVDPIEGtrmta-- 96  Escherichia coli
1FTA_A      103 iive-----------------------------------------------------pekrgkyvVCFDPLDGssnid-- 127 human
1INP         85 tndlgekiimrlgpteeetvallskvlngnklasealakvvhqdvffsdpaldsveinipqdilgIWVDPIDStyqyikg 164 cow
1DK4_A       71 dn----------------------------------------------------------ssewtVVIDPIDGsfnfi-- 90  Methanocaldococc...
1QGX_A       78 lsdafvsgilneikandevynknykkddf----lftndqfplksledvrqiidfgnyeggrkgrfWCLDPIDGtkgfl-- 151 baker's yeast
2HHM_A       75 geks------------------------------------------------------iltdnptWIIDPIDGttnfv-- 98  human
NP_376435    70 nk---------------------------------------------------------enyeyiAIIDPLDGstnyl-- 90  Sulfolobus tokod...
P22255       70 wev-------------------------------------------------------rqhwqryWLVDPLDGtkefi-- 92  Escherichia coli
NP_946257   122 re----------------------------------------------------------dadyvWVLDPIDGtksfi-- 141 Rhodopseudomonas...
ZP_00206943  78 eg----------------------------------------------------------rsgftWVIDPIDGtapfl-- 97  Rhodobacter spha...

Feature 1                                                                                       
1NI9_A       97 ------------mgqanALAVLAVGdkgcflnapdmymeklivgpgakgt------------------------idlnlp 140 Escherichia coli
1FTA_A      128 -------------clvsVGTIFGIYrkkstdepsekdalqpgrnlvaagyalygsatml-------vlamdcgvncfmld 187 human
1INP        165 saditpnqgifpsglqcVTVLIGVYdiqtgvplmgvinqpfvsqdlhtrrwkgqcywglsylgtnihsllppvstrsnse 244 cow
1DK4_A       91 ------------ngipfFAFCFGVFknnepyygltyefltksfyea--------------------------------yk 126 Methanocaldococc...
1QGX_A      152 -------------rgeqFAVCLALIvdgvvqlgcigcpnlvlssygaqdlkghesfgyi------fravrglgafyspss 212 baker's yeast
2HHM_A       99 ------------hrfpfVAVSIGFAvnkkiefgvvyscvegkmytar-------------------------------kg 135 human
NP_376435    91 ------------ngipwSSVSIAVYrrgekdilssftgvvgniftkki-----------------------------ysy 129 Sulfolobus tokod...
P22255       93 ------------krngeFTVNIALIdhgkpilgvvyapvmnvmysaaeg---------------------------kawk 133 Escherichia coli
NP_946257   142 ------------agfpvWGTLIALLhkgapvfgmmhqpfigerfsgdn----------------------------gsat 181 Rhodopseudomonas...
ZP_00206943  98 ------------aglphWCVVLALQeegrtvagviehplaretfsaq-------------------------------rg 134 Rhodobacter spha...

Feature 1                                                                                       
1NI9_A      141 ladnlrnvaaalgkplselTVTIlakprhdavi-----------aemqqlgvrVFAIPdgdvAASILTCmpdseVDVLYG 209 Escherichia coli
1FTA_A      188 paigefilvdkdvkikkkgKIYSlneayakdfdpavteyiqrkkfppdnsapyGARYVgsmvADVHRTLv---yGGIFLY 264 human
1INP        245 aqsqgtqnpssegscrfsvVISTseketikg--------------alshvcgeRIFRAagagYKSLCVIlg--lADIYIF 308 cow
1DK4_A      127 gkgaylngrkikvkdfnpnNIVIsyypskkid------------leklrnkvkRVRIFgafgLEMCYVAkg--tLDAVFD 192 Methanocaldococc...
1QGX_A      213 daeswtkihvrhlkdtkdmITLEgvekghsshde--------qtaiknklnisKSLHLds-qAKYCLLAlg--lADVYLR 281 baker's yeast
2HHM_A      136 kgafcngqklqvsqqeditKSLLvtelgssrtpetvrm-vlsnmeklfcipvhGIRSVgtaaVNMCLVAtg--gADAYYE 212 human
NP_376435   130 denfsyideekistphppdRLLIlayfsrsrllsv-------knfldslnadyKIRSLgsasLDMILVCtg--kASIYFD 200 Sulfolobus tokod...
P22255      134 eecgvrkqiqvrdarpplvVISRshadaelke------------ylqqlgehqTTSIGs--sLKFCLVAeg--qAQLYPR 197 Escherichia coli
NP_946257   182 ykgpsgerklgvrrcaaikDATLfttspllmndgd-------rgifekvqaeaRLTRYggdcYSYCMLAag--qLDLVIE 252 Rhodopseudomonas...
ZP_00206943 135 qgaflngerlraredltigSCNValgashrtspdfa-----salvrelmrrggMFYRNgsgaIMLASVAag--rLGGYYE 207 Rhodobacter spha...

Feature 1                      #                  
1NI9_A      210 igg----------apEGVVSAAVIRAlDGDMNGR 233 Escherichia coli
1FTA_A      265 pankkspngklrllyECNPMAYVMEKaGGMATTG 298 human
1INP        309 sedt-------tfkwDSCAAHAILRAmGGGMVDL 335 cow
1DK4_A      193 vrpk-------vravDIASSYIICKEaGALITDE 219 Methanocaldococcus jannaschii
1QGX_A      282 lpikls---yqekiwDHAAGNVIVHEaGGIHTDA 312 baker's yeast
2HHM_A      213 mgi---------hcwDVAGAGIIVTEaGGVLMDV 237 human
NP_376435   201 vrgk-------lrnvDVAASSNFCKRlGIIPRNS 227 Sulfolobus tokodaii str. 7
P22255      198 fgpt--------niwDTAAGHAVAAAaGAHVHDW 223 Escherichia coli
NP_946257   253 tel---------kpyDVAALIPIITGaGGIITTW 277 Rhodopseudomonas palustris CGA009
ZP_00206943 208 phm---------npwDCLAAMLMVEEaGGRTAPF 232 Rhodobacter sphaeroides

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