1CIV,1BMD,7MDH,1B8V,3D5T,1WZE


Conserved Protein Domain Family
MDH_choloroplast_like

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cd01338: MDH_choloroplast_like 
Click on image for an interactive view with Cn3D
Chloroplast-like malate dehydrogenases
MDH is one of the key enzymes in the citric acid cycle, facilitating both the conversion of malate to oxaloacetate and replenishing levels of oxalacetate by reductive carboxylation of pyruvate. Members of this subfamily are bacterial MDHs, and plant MDHs localized to the choloroplasts. MDHs are part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.
Statistics
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PSSM-Id: 133423
View PSSM: cd01338
Aligned: 37 rows
Threshold Bit Score: 493.643
Threshold Setting Gi: 8979401
Created: 30-Apr-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD(P) binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #  ###                         ##                                       
1CIV_A       41 KIINVAVSGAAGMISNHLLFKLASGEVFGpDQPISLKLLGSERS-----FAALEGVAMELEDSLYPLLRQVSIGID--PY 113 Flaveria bidentis
Q83C87        3 KHVKVAVTGAAGQIGYALLFRLASGQAFGlDTTVDLHLLEIEPA-----LPALKGVVMELEDCAFPLLRNMVVTSD--PR 75  Coxiella burnetii
Q5X2T6        4 NRVRVAVTGAAGQIGYALVFRIASGQMFGpNTEVELNLLELEPA-----LPSLEGVAMELDDCAFPLLKRIVCTAD--LN 76  Legionella pneum...
Q8F4A2        3 KTVKVAVTGAAGQIGYSLLFRIASGQMFGaDTAVEIQMLELEAA-----IPAAKGVIMELEDCAFPLLQKVTVSSD--LD 75  Leptospira inter...
A0L5T9        3 DPIRVAVTGAAGQIAYSLLVRLASGQLFGkDRKVELKLLEIPQA-----MGPLEGVMMELQDCAFPTLAKVEAFDN--PE 75  Magnetococcus sp...
Q6MAA3        3 QPIKIAISGGAGQIAYSLLFRLASGELFGpNQLIELQVLEVPNA-----LSALEGVKMEIEDCAFPLLSSIKICSD--PY 75  Candidatus Proto...
ZP_01874888   3 KTIRVCVTGAAGQIDYSLLFRIASGEMFGpEQKVALNLLEITPA-----LDALKGVAMELDDCAFPLLEEIVMTDD--VN 75  Lentisphaera ara...
ZP_02062099   5 KPIKIAITGAAGQIGYALLFRIASGQMFGaDQPVILHLLELEKS-----LPMLNGVAMELEDCAFPLLKNIICTSE--LK 77  Rickettsiella gr...
ZP_01853778   3 HPIRVAVTGAAGQIGYAMLFRLASGEIFGpDQPVILHLVEIPPM-----LSALDGVEMELDDCAFPTLAGVVKADSdhLE 77  Planctomyces mar...
ZP_02733851   3 KVVRVAVTGAAGRVSSSLIVRLASGEVFGpETKVVLQLLEVPASvnpaaLKNLEGAMYELQDCGFSTLKDVVITDD--PN 80  Gemmata obscurig...
Feature 1                    #                                       # #                       #
1CIV_A      114 EIFQDAEWALLIGAKPRGPGMERADLLDINGQIFAEQGKALNAVASpNVKVMVVGNPCNTNALICLKNAPnIPPKNFHAL 193 Flaveria bidentis
Q83C87       76 VAFNDVNWALLVGAAPRKAGMERKDLLEKNGSIFAGQGKAINENAAsDVRIFVVGNPCNTNCLIAMNNAPdIPKDRFYAM 155 Coxiella burnetii
Q5X2T6       77 KAMDGVNWALLVGSVPRKQGMERSDLLQINGGIFTKQGQAINDYASdDVRVFVVGNPCNTNCLIAMNHAKdVPSDRFYAM 156 Legionella pneum...
Q8F4A2       76 TAFKEINWALLVGSVPRKAGMERGDLLKINGGIFVNQGKAIEKNAAsDVRILVVGNPCNTNCLIAMNNAKgISQDRWFAM 155 Leptospira inter...
A0L5T9       76 QAFDGINWCLMVGSRPRGPGMERSDLIKINGPIFVNQGKALNRAAQ-DVRAVVVGNPCNTNCMIAAHNSD-VPHERFSAM 153 Magnetococcus sp...
Q6MAA3       76 QAFEDIDYALLIGAKSRGPGMERRDLLQENSKIFVNQGQALNAVAKsSAKIFVVGNPCNTNCLIALNNAPsLKRENFYAM 155 Candidatus Proto...
ZP_01874888  76 VAMKDVNWALLVGSKPRGPGMERGDLIKENGPIFTSTGKAINDHAAdDVRVVVVGNPCNTNCLIAMHNAPdVPRDRFHAM 155 Lentisphaera ara...
ZP_02062099  78 ESMKDINWAILVGSMPRKAGMERADLLKINGCIFAPQGKAMNAYAAsDVKIFVVGNPCNTNCLITMHHAPdIPKSRFFAM 157 Rickettsiella gr...
ZP_01853778  78 DAFADCNFVVCVGSIPRKAGMERGDLIRINGPIFTSTGKAIEAAAAeDVRVLVVGNPCNTNCLIAMSNAPkVPRDRWYAM 157 Planctomyces mar...
ZP_02733851  81 VAFNGCNYALLVGAAPRGPGEQRSDLIRKNGAIFVGQGQAIAKNAAsDVRILVVGNPCNTNCLIAYSNGRdVPADRWHAM 160 Gemmata obscurig...
Feature 1                                      #                                                
1CIV_A      194 TRLDENRAKCQLALKAGVFYDKVSNVTIWGNHSTTQVPDFLNAKIHGIPVtevIRDRKWLEDEFTNMVQTRGGVLIKKWG 273 Flaveria bidentis
Q83C87      156 TRLDQNRAIGQLALKAGVDVPSVKNMIIWGNHSSTQYPDFYHATIDGKPAtevIRDKNWLLNDFISVIQQRGAAVIKARG 235 Coxiella burnetii
Q5X2T6      157 TTLDELRARTQLAKKAGVDITAVTQMTIWGNHSATQYPDFYNAKINGTSAaqvINDETWLKETFVSTVQQRGAAVIKARG 236 Legionella pneum...
Q8F4A2      156 TKLDENRAKSQLASKAGVPVKEVTHLGIWGNHSATQYPDFYNTKISGKPVtdvISDHEWLKGDFIKNVQQRGAEIIKARG 235 Leptospira inter...
A0L5T9      154 MRLDQNRAKYLLASKAGAQVIDVTNVVIWGNHSNNQVPDFEFAKIGGKPVpevIADAAWLENAFMPTVQNRGAAVIKARG 233 Magnetococcus sp...
Q6MAA3      156 TRLDQNRATFFLSQKSQVSTKDVSCVTIWGNHSATQVPDFVNAKISQKPVetiIPDRQWLEKDFIESVQKRGAAIIQARG 235 Candidatus Proto...
ZP_01874888 156 TRLDENRAKSQLAQKAGVAVTEVKNMVIWGNHSATQVPDYKNATISGKPAadvIGDLAYLQSEFTSTVAKRGAAIIAARG 235 Lentisphaera ara...
ZP_02062099 158 TLLDENRARAQLAKKAAVSVSEVTQMAVWGNHSSTQYPDFYHAKIAHQAVidvIPDKNWLENDFIHRVQKRGAAVIKARG 237 Rickettsiella gr...
ZP_01853778 158 TRLDQNRAMTQIAKKAGQPVSAVKNMNIWGNHSATQFPDFYHATIHGNPVpeiIEDHDWLRGEFIETVQKRGAAVIQARG 237 Planctomyces mar...
ZP_02733851 161 TRLDHNRAVSALAIKAGVTNDAVTCVTIWGNHSNTQYPDFTNAKIGGRPAtevITDRAWLENTFVPNTQERGKFIIDTTK 240 Gemmata obscurig...
Feature 1                                                                                       
1CIV_A      274 RSSAASTAVSIVDAIRSLVTPTpegDWFSTGVYTNGnPYGIAEDIVFSMPCRSKGDGdyEFVKDVIFDDYLSKKIKKSED 353 Flaveria bidentis
Q83C87      236 ASSAASAANAALDSVWSLINTTpadDNYSVALCAQG-QYGVDEGLIFSFPCRTENGVv-SVIEEIEHNEFGQQKLKETLD 313 Coxiella burnetii
Q5X2T6      237 SSSAASAANAIITGVNHLVTDTpagESFSMCRRSKG-EYGVDEGLIFSFPCRREHGEl-KVVENLEFNDFGRERFNTTLN 314 Legionella pneum...
Q8F4A2      236 ASSAASAANGVVDTVRGIITPTapgDCFSAAVVSDG-SYGAEKGLIFGFPLKSDGKKv-EIIQGISLNDFAKEKFKITHE 313 Leptospira inter...
A0L5T9      234 ASSAASAANAALDHVRSLITPTpagDTFCAAVMANG-AYGVDAGLIAGMPLTSTGHGdwSIVEGVPMSPFIKGKFDAVLD 312 Magnetococcus sp...
Q6MAA3      236 KSSAASAASALLDAMRDRILPTptgQWFSTALLSDGnPYGIEEGLIFSFPCRVKKNGelSIVSGLKWDAFLEEKIKLTEQ 315 Candidatus Proto...
ZP_01874888 236 KSSAASAANGLIDHVKSLLTPTpegEVFSSCVCSDGnPYGIPEGLIFSFPCRSNGDGtyEIVPGFELDSHLTDGVAKTVA 315 Lentisphaera ara...
ZP_02062099 238 ASSAASAANAVVDSIYHLTHDTqkdDFFSVASCSMG-QYGVDEGLIFSFPSRVENNQl-KVVTDIQHNLFGEEKIKLSLN 315 Rickettsiella gr...
ZP_01853778 238 ASSAASAANAALDTIKSIITPTplgESFSAAVCSDG-SYGVDEGLICGYPLTSDGTTw-KIVEGQEHDDFAQAKFEATLQ 315 Planctomyces mar...
ZP_02733851 241 VSSSFSAANGAIDHVKSLVTGTpagDWTSAAIVSKG-EYGVPAGLVFGYPCTTSGDGnwNVVEGLKLDAFGEAKFKKTLD 319 Gemmata obscurig...
Feature 1                  
1CIV_A      354 ELLAEKKCVAH 364 Flaveria bidentis
Q83C87      314 ELREERDAVEA 324 Coxiella burnetii
Q5X2T6      315 ELRSERDTVKS 325 Legionella pneumophila str. Paris
Q8F4A2      314 ELVSERNEVKE 324 Leptospira interrogans
A0L5T9      313 ELRREREMVKD 323 Magnetococcus sp. MC-1
Q6MAA3      316 ELKEEREMVSS 326 Candidatus Protochlamydia amoebophila UWE25
ZP_01874888 316 ELEGEREVIKG 326 Lentisphaera araneosa HTCC2155
ZP_02062099 316 ELRAEKNEVKE 326 Rickettsiella grylli
ZP_01853778 316 ELRDERDVVRD 326 Planctomyces maris DSM 8797
ZP_02733851 320 ELLKEQEVVKD 330 Gemmata obscuriglobus UQM 2246

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