Conserved Protein Domain Family
PDC_hydrolase
?
cd01311: PDC_hydrolase 
2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most important intermediate metabolites in the bacterial pathways for various phenolic compounds, including lignin, which is the most abundant aromatic material in nature.
Links
?
Statistics
?
PSSM-Id: 238636
Aligned: 8 rows
Threshold Bit Score: 267.773
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
active site
Feature 1:active site [active site]
Evidence:
  • Comment:active site is based on homology to other members of the amidohydrolase family
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1          # #                                                                        
NP_883594  28 GACDTHAHIFgpvsrypldpkrtfnppragidDYRRLLSTlg---leRAVIVHSGAYGt---DISVTRDAlla-seGKWR 100 Bordetella paraper...
CAE30140   26 GAVDAHCHVFgpgeefpfaperkytpcdasneQLYALRDHlg---fsRNVVVQATCHGa---DNRAMVDAlvh-snGKAR 98  Rhodopseudomonas p...
BAD04056   27 GAVDAHCHVFgpgnefpfaperkytpcdaskaQLYALRDHlg---faRNVVVQATCHGa---DNRAMVDAcks-sgGKAR 99  Pseudomonas straminea
CAE36909   11 GGWDCHFHVFdasrytlaa----gsayqpedaSLAAFRGVcrargigRAVLVHPSVYGa---DHSSYEDAla--anGDWL 81  Bordetella paraper...
EAA65968   37 GAWDCHMHVTdrkypvvagaa-yqtrpgqgidDAMAFESTlr---ikNVVLVQPSIYGt---DNSCLLDAlr--rvGPSR 107 Aspergillus nidula...
AAK90248   20 GAVDTQMHMYlpgypalpggpglppgalpgpeDYRRLMQWlg---idRVIITQGNAHQr---DNGNTLACva--emGEAA 91  Agrobacterium tume...
EAA47004   62 LSFDAHVHCFnpsrhpfka----srtytpeaaPLSALVAAsl---adRIMIVQASIEDgpanLIDNLRDAraqhpdKLFR 134 Magnaporthe grisea...
AAO89653    5 LIFDSHFHIIdprfplipnq--gfvpssftvdDYLSVTKGln---ivGGAIVSGSFQGf---DQTYLESAlq--klGNHF 74  Coxiella burnetii ...

Feature 1                                                                        #            
NP_883594 101 GIAlv------drDVTRDALAdm-hAAGFRGVRFNFIfghrn--eeddvLEIARRIa------eFGWHIQLLvdartlpD 165 Bordetella paraper...
CAE30140   99 GVAtv------krSVTDAELQam-hDAGVRGVRFNFVkrlvdftpkdelVEIAGRIk------eLGWHVVIYfeavdlsE 165 Rhodopseudomonas p...
BAD04056  100 GVAtv------krSISDAELSal-hDAGVRGVRFNFVkrlvdftpkdelMEIAGRIa------kLGWHVVIYfeavdlpE 166 Pseudomonas straminea
CAE36909   82 RGVavvy--pdeaTTPDARIEhw-dLLGTAGTRINRLfpga----pqhpERIVERVk------pFGWHVQVLtdivediG 148 Bordetella paraper...
EAA65968  108 GRGvvdi---dprETKVSTLRew-hSLGVRGVRVNFMskgvtpvhqqldDALSKRArli---rdLGWMIQVHtpmstmpH 180 Aspergillus nidula...
AAK90248   92 HAVvi------idATTTEKDMekltAAGTVGARIMDLpggav--nlselDAVDERAh------aADWMVAVQfdgngllD 157 Agrobacterium tume...
EAA47004  135 GTVfadpepgrglDALSAGDFamlhDLGVRSIRIHGSyggnga-naswvQEQFRRAaaldgvatHGWSVSAQlplamwaA 213 Magnaporthe grisea...
AAO89653   75 VGAtql-----pgTASEEEIKel-hKKGVRAVRFNLKrggsa--svgdcESLAKRVfn-----vAGWHSEFYvdsrdlpA 141 Coxiella burnetii ...

Feature 1                        #                                                            
NP_883594 166 LLPLIrrl----pvmVVIDHIGrmptsa--gigdpgFQALLgll--------rerRCWVNLsganrmgd--------ptp 223 Bordetella paraper...
CAE30140  166 LWDFFtal----pttVVVDHMGrpdvtk--pvdgpeFELFVkfmr-------ehaNVWSKVscperlsvsgppalngeqn 232 Rhodopseudomonas p...
BAD04056  167 LWDFFtal----pttVVVDHMGrpdvtk--gvdseeFALFLkfmr-------ehqNVWSKVscperlsvtgpkalhgeqn 233 Pseudomonas straminea
CAE36909  149 LVRRIaar----dvpVVVDHFGhhphaq--llrsagWQDLLalv--------regAAWVKLsapyrvga--------qgp 206 Bordetella paraper...
EAA65968  181 LEEIIpkl----gvkVCIDHFGcpdlpklkwdqgayFDPYLlrgfpslmnllqggLTWVKIsapyrfs---------kde 247 Aspergillus nidula...
AAK90248  158 HLPRLqki----rsrWVFDHHGkffkgi--rtdgpeMAALLkli--------drgNLWFKFagvyessr--------ksw 215 Agrobacterium tume...
EAA47004  214 IGEFLqhdaalagvaVVADHNGsatped---vgsaeFAAFLrll--------eaqTVHVKVgalhrrs----------pe 272 Magnaporthe grisea...
AAO89653  142 ISPLLekl-----paIVIDHLGlsk---------agFPFLLkli---------ekGAYVKAsgfgr-------------- 184 Coxiella burnetii ...

Feature 1                             #                                                     
NP_883594 224 pyasVVPFAHALVdagadhLVWGTDWPHVrep--------gaiPDDGGLLNLLQLWVPd---rRLRNai-lSDNPARL 289 Bordetella parapertu...
CAE30140  233 ayrdVIPFARRIVetfpdrVLWGTDWPHPnlk--------dhmPDDGLLVDFIPHIASt---pELQRkl-lVDNPMRL 298 Rhodopseudomonas pal...
BAD04056  234 ayqdVVPFARRVVeefpdrVLWGTDWPHPnlk--------dhmPDDGLLVDFIPHIAPt---aQLQQkl-lVDNPMRL 299 Pseudomonas straminea
CAE36909  207 awpgAQALVDQLVqanprqLVWGSDWPHPpdhrh-----pfpaPDQAAIGATIAQWLPd---aQLRRqv-mELNPLRL 275 Bordetella parapertu...
EAA65968  248 klrdMDVLAREFIreaptrVVYATDWPHTrfrn------vdiePFTEMCLRRCGSWAVa---kRVFRynteELMDCRL 316 Aspergillus nidulans...
AAK90248  216 pyadVAAFSRVIAahaperIVWGTNWPHNsvre------taayPDDARLAELTLGWLPd----EAARhralVENPEAL 283 Agrobacterium tumefa...
EAA47004  273 diarMKAVVEGFAasgpgmMVWGSDWPHVdttqgpevvspplvVDTPAELRAIRSWVSd---eQWQRl--lVENPARL 345 Magnaporthe grisea 7...
AAO89653  185 ldfsIIAALQQIIainpasLLFGTDLPSTra----------prPFMIEDIRLIEENFSseiagKIFYnnalKPYDVRL 252 Coxiella burnetii RS...

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap