1NF8


Conserved Protein Domain Family
isochorismatase
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cd01013: isochorismatase 
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Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological systems. Isochorismatase is part of the phenazine biosynthesis pathway. Phenazines are antimicrobial compounds that provide the competitive advantage for certain bacteria.
Links
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Statistics
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PSSM-Id: 238495
Aligned: 12 rows
Threshold Bit Score: 350.485
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1NF8; Pseudomonas isochorismatase active site mutant with bound isochorismate
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                              #                                        
1NF8_A        3 GIPEITAYPLPta----qqLPANLARWSLEPRRAVLLVHAMQRYFLRPlp--esLRAGLVANAARLRRWCVEQGVQIAYT 76  Pseudomonas aeru...
O07900        2 AIPKIASYPLPv------sLPTNKVDWRIDASRAVLLIHDMQEYFVHYfdsqaePIPSLIKHIQQLKAHAKQAGIPVVYT 75  Vibrio cholerae
AAN28931      2 SIPKIASYSMPqa----heFTPNKTHWQLHTNRAVLLVHDMQQYFLDFydqtqaPIPELIRNTKELIKTARKFNIPVVYT 77  Acinetobacter ba...
AAN40891      3 RTLKSESYSLSni----iiPDEQPLAWNIEPQRSALLVHDMQRYFVDAlp--cePVDTVIHSISLILKWARINEIPVFYS 76  Pantoea agglomerans
AAG33854      2 AIPKIASYQVLpl----esFPTNKVDWVIDPKKSVVLVHDLQAYFLNFfdktlsPVPELLRNVNKVTESARSAGIPVVYT 77  Listonella angui...
P45743        2 AIPAIQPYQMPta----sdMPQNKVSWVPDPNRAVLLIHDMQNYFVDAftagasPVTELSANIRKLKNQCVQLGIPVVYT 77  Bacillus subtilis
Q51790        3 GIPSIVPYALPts----rdLPANLAQWHIDPERAVLLVHDMQRYFLRPlp--daLRDQVVGNAARIRQWAADNGVPVAYT 76  Pseudomonas fluo...
P15048        2 AIPKLQAYALPes----hdIPQNKVDWAFEPQRAALLIHDMQDYFVSFwgencpMMEQVIANIAALRDYCKQHNIPVYYT 77  Shigella flexneri
BAC16759      2 TIPSISDYPMPva----asFPANKTKWQPDAKRAVLLIHDMQRYFLRFyeadgkLMTTLIDNLAKVKAWAVQNSVPVIYT 77  Agrobacterium tu...
ZP_00059515   2 SLPAITPYPLPtv----dqLPANRAEWQITPARAVLLVHDMQRYFLRPyaesadPLRGVLTNISTLADTCRTLGIPVIYT 77  Thermobifida fusca
ZP_00067347   2 AIPKINNYSLTgqvkatneEYGNRVSWPLDANKAVLLVHDMQKYFVEFydqqgePMRSLVQNIQTIVAQCKAAGIPIVYT 81  Microbulbifer de...
ZP_00089387   2 AIPRIASYPMPaa----etFPSGRVDWQADPKRVALLVHDMQEYFIDFydrsaaPIPQLVANIRRLIDACDAAGVPVYYT 77  Azotobacter vine...

Feature 1        #        #                                   #                            #   #
1NF8_A       77 AQPGSMTEEQRGLLKDFWGPGMras-padREVVEELAPGPDDWLLTKWRYSAFFHSDLLQRMRAAGRDQLVLCGVYAHVG 155 Pseudomonas aeru...
O07900       76 AQPANQDPAERALLSDFWGPGLse----eTAIIAPLAPESGDVQLTKWRYSAFKKSPLLDWLRETGRDQLIITGVYAHIG 151 Vibrio cholerae
AAN28931     78 AQPGNQTPEHRQLLTDFWGTGLkdd-pyiTQILPEISPQKNDTVLTKWRYSAFKFSPLEQLMRESGRDQLIICGVYAHIG 156 Acinetobacter ba...
AAN40891     77 AQPGGMTPEQRGLLNDLWGPGMrtt-edeRKIITELTPSPGDTVLTKWRYSAFYRSPLAEMLKNDQRDSLIITGIYASVG 155 Pantoea agglomerans
AAG33854     78 AQPANQDPNERALLTDFWGVGLtq----dTEIVPEVSPQPEDIQYTKWRYSAFKKTPLLEWMKEEQRDQLVIVGVYGHIG 153 Listonella angui...
P45743       78 AQPGSQNPDDRALLTDFWGPGLnsg-pyeEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIG 156 Bacillus subtilis
Q51790       77 AQPGSMNEEQRGLLKDFWGPGMkas-ptdREVVDALAPQPGDWLLTKWRYSAFFNSDLLQRLHASGRDQLILCGVYAHVG 155 Pseudomonas fluo...
P15048       78 AQPKEQSDEDRALLNDMWGPGLtrs-peqQKVVDRLTPDADDTVLVKWRYSAFHRSPLEQMLKESGRNQLIITGVYAHIG 156 Shigella flexneri
BAC16759     78 AQPHDQPPGDRALLNDMWGPGLtvvdpelQKVVDKLAPTPQDVVLTKWRYSAFQRSDLTERMKGWGRDQIIVGGVYAHIG 157 Agrobacterium tu...
ZP_00059515  78 VKPGGMDPAQRGLELHFWGRGMsat-dehTAIDTRIAPRPTDLVVVKARYSAFVGTDLAARLADLNRDQIIVTGVYAHIG 156 Thermobifida fusca
ZP_00067347  82 AQPPHQAPEERALLTDFWGAGLtse-nnqHAIVESLKPAADDLVFTKWRYSAFQRTPLHEYMAENNKDQLWIVGVYAHIG 160 Microbulbifer de...
ZP_00089387  78 AQPAVQPAGDRALLNEFWGPGLpak-pegAPVIAALAPRENHVVLDKWRYSAFIRSDLRERLQAAGRDQLMVCGIYAHIG 156 Azotobacter vine...

Feature 1                                                       
1NF8_A      156 VLISTVDAYSNDIQPFLVADAIADFSEAHHRMALEYAASRCAMVVTTD 203 Pseudomonas aeruginosa
O07900      152 ILSTALDAFMFDIQPFVIGDGVADFSLSDHEFSLRYISGRTGAVKSTQ 199 Vibrio cholerae
AAN28931    157 CLMSAAEAFMLNIQPFLCGDALADFSREEHDMALKYASTRCAQVMTTQ 204 Acinetobacter baumannii
AAN40891    156 ISATAIDAFTQDIKPFVTADGIADFSLAGHQQAINYLADNCAKIISTD 203 Pantoea agglomerans
AAG33854    154 ILSTALDAFMLDIKPFVIGDAIADFSKEDHMNTLKYVASRSGSVKSVD 201 Listonella anguillarum
P45743      157 CLVTACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTD 204 Bacillus subtilis
Q51790      156 VLISSVDAYSNDIQPFLVADAIADFSKEHHWMAMEYAASRCAMVITTD 203 Pseudomonas fluorescens
P15048      157 CMTTATDAFMRDIKPFMVADALADFSRDEHLMSLKYVAGRSGRVVMTE 204 Shigella flexneri
BAC16759    158 CMMTAVEAFMKDIQPFMIGDGVADFSEAEHRMALQYVATRCGVVIDTA 205 Agrobacterium tumefaciens
ZP_00059515 157 CLLTAADAFMRDIQPFLVADATADFSAEEHRFALTYAATRCAMVTSTA 204 Thermobifida fusca
ZP_00067347 161 ILSTALEAFMTDIKAFVVADAVADFSSTEHSMALHYISRRCGRVVALQ 208 Microbulbifer degradans 2-40
ZP_00089387 157 CQTTCVDAFMRDVQPIMVGDALADFSPERHRQALDYVVACAGVVRDTD 204 Azotobacter vinelandii

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