Conserved Protein Domain Family
PI4Ka
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cd00871: PI4Ka 
Phosphoinositide 4-kinase(PI4K), accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. PI4K phosphorylates hydroxylgroup at position 4 on the inositol ring of phosphoinositide, the first commited step in the phosphatidylinositol cycle.
Links
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Statistics
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PSSM-Id: 238443
Aligned: 8 rows
Threshold Bit Score: 273.463
Created: 4-Feb-2003
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P37297    1362 TFAKDPTLAINLLQRCy-SKKAEDVLVGLVAKHALMCvGSPSALDLFikg-shLSSKKDLHATLYWAPVSPLKSINLFLP 1439 baker's yeast
P42356     299 AWSISPYLAVQLPARFknTEAIGNEVTRLVRLDPGAVsDVPEAIKFLvtwhtiDADAPELSHVLCWAPTDPPTGLSYFSS 378  human
AAM29653   754 AWCYNPALAVFLPQRIknAEIIDEEVSRLVCSDPIAVcHIPEALKYLcttknlLQESPDLVYILSWSPVTPIQALAYFSR 833  fruit fly
EAA34541  1395 AWLESPSLAVHLASRFp-YPRVKQEVRWLLLNFPAKAiKEPEAVATLvdgslpEDVSFQLKYLLFWAPVNPITSITFFLP 1473 Neurospora crassa
NP_595304 1322 AWNVSPNIVLYAPKRFq-NAPLKQMALNFVIANPFTSvKHEVALEYLfehypsGEFPIDRKFILYWEPMYPVSGPVMFMP 1400 fission yeast
NP_499596 1559 AWDISPELAIQLPSRFrgSPELVKYVDVLVRGQPEPVaHIPEALPLFlgngstVFETSDMSHVLTWARCSPVMALSLLTP 1638 Caenorhabditis e...
AAO52035  1790 AWKINPKLAIHFSSRFp-HSKIKSLLSEMVVKNTKAVlDIPEALPFLvteenvKANIPELKYLLYWETVTPPMAISLLGK 1868 Dictyostelium di...
AAK38486  1349 AFAVDPRIAFSMIMRFptNSALSSEITQLVQTHILELrTIPEALPFFitpkavDENSSLLQQLPHWAPCSVTQALEFLTP 1428 Japanese rice

P37297    1440 E-WQGNSFILQFSIYSLESQDVNLAFFYVPQIVQCLRYDktGYVERLILDTAKISVLFSHQIIWNMLANCYKddegi--- 1515 baker's yeast
P42356     379 M-YPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDkmGYVREYILWAASKSQLLAHQFIWNMKTNIYLdeegh--- 454  human
AAM29653   834 Q-YPSHPLTAQYAVKTLSSYPAESVLPYIPQLVQALRHDtmGYVVEFIKNISRRSQIVAHQLIWNMQTNMYMdedqq--- 909  fruit fly
EAA34541  1474 A-YRNHPYLIQYAMRALESHSVDVTFFYVPQIVQTLRYDalGYVERYILETAQFSQLFAHQIIWNMKANAYKdedat--- 1549 Neurospora crassa
NP_595304 1401 N-VKWNPQLLQYTMRSMESYPVSVTFFYVPQIVQSLRYDsmGYAESFILETSGTSQLFAHQILWNMKANLYKdeaat--- 1476 fission yeast
NP_499596 1639 RiYPMHPISMQYAVRVLRSYSADELLLYIPQIVQAVRYDtmGYISELIIWLAGHSQLLSHQLIWNMQTNMFTdeesk--- 1715 Caenorhabditis e...
AAO52035  1869 Q-YHSHPLVSQYACRVLRSFPPETIMFYIPQLTQALRYDrsGQVENYLVQASKTSELLAHQIIWNVQTYTESdpngrma- 1946 Dictyostelium di...
AAK38486  1429 P-YKGHPRVMAYVLRVLETYPPETVTFFMPQLVQSLRYDddKLVEGYLLGAARRSNIFAHILIWHLQGECVPdepgkeaa 1507 Japanese rice

P37297    1516 --qedeIKPTLDRIRERMVSS 1534 baker's yeast
P42356     455 -qkdpdIGDLLDQLVEEITGS 474  human
AAM29653   910 -hkdpnLYEALDQLSQSIIAS 929  fruit fly
EAA34541  1550 --ipdtIKPTLDKVMGHMIDS 1568 Neurospora crassa
NP_595304 1477 --vpdsIKPILDRVMDKMINS 1495 fission yeast
NP_499596 1716 -vkdpvLFEALNDIMQKILSQ 1735 Caenorhabditis elegans
AAO52035  1947 piddpiIQNVAKRLKDRVIEE 1967 Dictyostelium discoideum
AAK38486  1508 apkataFHSLLPAVREKIVDG 1528 Japanese rice
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