1A2Z,1IOF,1IOI,1AUG,1IU8


Conserved Protein Domain Family
Peptidase_C15
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cd00501: Peptidase_C15 
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Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from proteolysis by other proteases until the pGlu is removed by a PGP. PGPs are cysteine proteases with a Cys-His-Glu/Asp catalytic triad. Type I PGPs are found in a wide variety of prokaryotes and eukaryotes. It is not clear whether the functional form is a monomer, a homodimer, or a homotetramer.
Links
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Statistics
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PSSM-Id: 238279
Aligned: 56 rows
Threshold Bit Score: 135.088
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic triad [active site]
Evidence:
  • Structure:1a2z_a, Active site residues of Pyrrolidone Carboxyl Peptidase From Thermococcus
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1A2Z_A      2 KKVLITGFEPFG-GDSKNPTEQIAKYFDrkqi------------------gnamVYGRVLPVS----VKRATIELKRYLE 58  Thermococcus litor...
AAH75524    6 IAVVVTGFGPFG-EHTVNASWVAVQELGklglg-----------------kevdLHIYEIPVE----YQTVQRLIPALRK 63  western clawed frog
NP_060182   6 KAVVVTGFGPFG-EHTVNASWIAVQELEklglg-----------------dsvdLHVYEIPVE----YQTVQRLIPALWE 63  human
XP_425083  18 VSVSRQGFGPFR-QYLVNSSWEAVKELSkrglg-----------------knidLRIMQLPVV----YQKAKEQIVRIWT 75  chicken
CAC33026    6 RTAVVKGFGPFG-EHTVNASWVAVQQELkklgl----------------gsevdLHVLEVPVE----YQTVQSLVPSLWK 64  torafugu
CAG00772    3 SCVSFSGFGPFG-EHTVNASWVAVQELK--------------------------KLGLGGEVDl---QVMEVPVEYQTVQ 52  Tetraodon nigrovir...
NP_730035   7 KLIVVSGFGPFLgHEAVNASWEAVKLLPeilth----------------dgieyDLEKRLVSV----EYGAVDEAVAEIW 66  fruit fly
EAA76778   11 INVLVTGFGPFReQYPINPSWEIASSLPshlpplrakdpnsrhaaillpnvrisVHPEPIRVN----YQVVRGLVPSFYD 86  Gibberella zeae PH-1
NP_947173   4 LRILITGFGPFP-GAPYNPTPQLVDRLVklrrpa---------------fddvvRVGHIFNVS----YRAVDRDLPALLA 63  Rhodopseudomonas p...
EAA04416    6 KIIIVTGFGPFAgHEERNASWEAVKLLPdvf--------------------hfrKDAYQLRKYqvpvIYEEVNRILPQIW 65  Anopheles gambiae ...

Feature 1                                 #                                                   
1A2Z_A     59 EIKP------EIVINLGLAPTY-SNITVERIAVNIIDARI----PDNDGYQPIDEKIEE------DAPLAYMATLP---V 118 Thermococcus litor...
AAH75524   64 KHKP------KVIVHVGVSGMA-TAVTLEKCGHNTGYQGL----DNCEFCPGTQCCVEG------GPECLHSVIDI---D 123 western clawed frog
NP_060182  64 KHSP------QLVVHVGVSGMA-TTVTLEKCGHNKGYKGL----DNCRFCPGSQCCVED------GPESIDSIIDM---D 123 human
XP_425083  76 TLHP------ILTVHVGLASSA-KAIIILEQCGKNKGYEE----MDACGFHPEGGCCML------NGPEKIESTIN---M 135 chicken
CAC33026   65 QYRP------QLVVHVGVSGMA-TTVTLEKCGRNHGYRGL----DNSSFCPDNQCCIVG------GPDCIYSVIDM---E 124 torafugu
CAG00772   53 SLVPslwkqhRPLLVVHVGVSGmATTVTLEKCGRNHGYRG----LDNSSFCPDSQCCVV------GGPDCIYSVID---M 119 Tetraodon nigrovir...
NP_730035  67 KRQP------YLVIHVGVSGVA-KCVYIEKLAYNHKFRRA----DNCDKKLANGTCELPn----nGHANVLKTELD---V 128 fruit fly
EAA76778   87 ATRPf-----DVVIHIGMAGPR-PFYSIERRGHRDGYKHPdvdgEFVDSEEDRQKDDWPw----rGLPEEIETELDldqV 156 Gibberella zeae PH-1
NP_947173  64 QHRP------DALLMFGLAAST-RHVRIETRARNAITTLW----PDAEKVTLRHGQIAPg-----EDARTFGAHGAr-lA 126 Rhodopseudomonas p...
EAA04416   66 NQKP------DLVVHVGVNGTI-NTINLEHFSYTFGYSKP----DFAQHYLPSDKITLSgkhandKECAMLKTNLN---V 131 Anopheles gambiae ...

Feature 1                                             #                            #          
1A2Z_A    119 RAITKTLRDNGI--PATISYSAGTY--------------LCNYVMFKTLHFSKIEgy-----plKAGFIHVPYTPDQVvn 177 Thermococcus litor...
AAH75524  124 TVCKRAAEACLDv-QFTVSTDAGRY--------------LCDFTYYTSLYQSHGRsv-----fiHVPPLGKPYTAIQLg- 182 western clawed frog
NP_060182 124 AVCKRVTTLGLDv-SVTISQDAGRY--------------LCDFTYYTSLYQSHGRsa-----fvHVPPLGKPYNADQLg- 182 human
XP_425083 136 KTIWKNISVEGI--DTIFSRDAGRY--------------ICDYTYYTSLYYGSGR---------AAFIHVPPLSKSVTa- 189 chicken
CAC33026  125 SVCKRVTSSGLGv-AVSVSKDAGRY--------------LCDFTYYTSLYLSRGRsa-----fiHVPPLGKPYSREDLg- 183 torafugu
CAG00772  120 ESVCKRVTASGLgvAVSVSKDAGRY--------------LCDFTYYTSLYLSHGRsa-----fiHVPPLGKPYSREDLg- 179 Tetraodon nigrovir...
NP_730035 129 DKIVAVVNENCAd-CVGPTQQPTHNdnlkslsatkasknVGDFLCGYIYLKSLDMdr------kRSLFVHVPPVDRPFs- 200 fruit fly
EAA76778  157 LSLWQGHSSEYD--DVRISEDAGHY--------------LCDFIYYSSLSELWKQkrprktvflHVPADASPSSIERGrd 220 Gibberella zeae PH-1
NP_947173 127 RAARLTGIDARL--SRDAGRYLCNY--------------LCWRGIEATQVQSGPR---------LAAFVHVPLISRDGta 181 Rhodopseudomonas p...
EAA04416  132 ERLVKELNLETNv-ECCCSTNVGNY--------------LCGYIYVKSLDVNQDRtl-----fvHVPEVNEPYTSEQTm- 190 Anopheles gambiae ...

Feature 1                                                                      
1A2Z_A    178 kffl-------------------lgkntPSMC----------------------LEAEIKAIELA 201 Thermococcus litoralis
AAH75524  183 ----------------------------QAIQt--------------------iIKVILDMLEQS 199 western clawed frog
NP_060182 183 ----------------------------RALRa--------------------iIEEMLDLLEQS 199 human
XP_425083 190 ----------------------------DSLGk--------------------aLQTIILEMLKQ 206 chicken
CAC33026  184 ----------------------------RALQa--------------------vVREMLELLDQA 200 torafugu
CAG00772  180 ----------------------------RALQa--------------------iIRGMLELLEQA 196 Tetraodon nigroviridis
NP_730035 201 ---------------------------sVKTSeil----------------fsiVEQCIQQVVAF 222 fruit fly
EAA76778  221 ltlnlirsiveseiiaknkplesklsphPEMLkatcgtcnktswwgcgshipsvMDNIPDADRCA 285 Gibberella zeae PH-1
NP_947173 182 ---------------------------wPGSRitteqlvdag---eamllelvrLTRQTRRVAAA 216 Rhodopseudomonas palustris CGA009
EAA04416  191 ----------------------------TTIYn---------------------VIGKCLEQLAA 206 Anopheles gambiae str. PEST

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