1BKD


Conserved Protein Domain Family
RasGEF

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cd00155: RasGEF 
Click on image for an interactive view with Cn3D
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety of signals. GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors.
Links
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Statistics
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PSSM-Id: 238087
Aligned: 30 rows
Threshold Bit Score: 170.896
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Ras interaction
Conserved site includes 49 residues -Click on image for an interactive view with Cn3D
Feature 1:Ras interaction site [polypeptide binding site]
Evidence:
  • Structure:1BKD_S, human SOS interaction with Ras
  • Citation:PMID 9690470

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                       ###                  ## ### ##  ##  #          
1BKD_S     171 LLTLHPIEIARQLTLLESDLYRAVqpseLVGSVWTKedkei---------nspnLLKMIRHTTNLTLWFEKCIVeten-l 240  human
5901914    768 FELMSSKDLAYQMTIYDWELFNCVheleLIYHTFGRhnfkk---------ttanLDLFLRRFNEIQFWVVTEIClcsq-l 837  human
6912456    341 ILGMNTWDLALELMNFDWSLFNSIheqeLIYFTFSRqgsge---------htanLSLLLQRCNEVQLWVATEILlcsq-l 410  human
7506314    328 VLCNDAKTVAQQLTHIEMERFSMVgvdeIVQSLASDplseigrhsknkegtissISFYIEWFNRLSAFAAIEVLkqtk-k 406  Caenorhabditis e...
4079657    619 LDLVSAKDLAGQLTEHDWNLFNRIhqveLIHYVLGPqhlrd--------vttanLERFMRRFNELQYWVATELClcpv-p 689  Norway rat
7657261    713 LLQLSTVEVATQLSMRNFELFRNIepteYIDDLFKLrskt----------scanLKRFEEVINQETFWVASEILretn-q 781  human
5032025    201 FDHLEPEELSEHLTYLEFKSFRRIsfsdYQNYLVNScvke-----------nptMERSIALCNGISQWVQLMVLsrpt-p 268  human
6665669    890 LLSLNAQVVAAQLTLQDFSVFSAIepteFLDNLFKLdsky----------gspkLEEFEQLFNREMWWVATEICterh-v 958  Caenorhabditis e...
7512120    565 LLSVDPFKLARHMTVIDCKVCRIMeg-eLENALLPHgh--------------qlRQDIIERYQCIAFWVAICVIkctnhg 629  Halocynthia roretzi
7499779    178 FVQASPSDISTSLSHIDYRVLSRIs--iTELKQYVKdghlr---------scpmLERSISVFNNLSNWVQCMILnktt-p 245  Caenorhabditis e...
Feature 1                              #  ## ### #### ##                    #  #    ###  #     
1BKD_S     241 eeRVAVVSRIIEILQVFQE-LNNFNGVLEVVSAMNSSPVYRLDHTFEQIps-rqKKILEEAHELSe--dHYKKYLAKLRs 316  human
5901914    838 skRVQLLKKFIKIAAHCKE-YKNLNSFFAIVMGLSNIAVSRLALTWEKLps-kfKKFYAEFESLMdpsrNHRAYRLTVAk 915  human
6912456    411 gkRVQLVKKFIKIAAHCKA-QRNLNSFFAIVMGLNTASVSRLSQTWEKIpg-kfKKLFSELESLTdpslNHKAYRDAFKk 488  human
7506314    407 rnRVAVFEFMIDIAKECCE-IGNFNSMMAIVAGLSLPAVSRLKKTWCRVekaklEILQHQLDPSG----NFLSYRATIKa 481  Caenorhabditis e...
4079657    690 gpRAQLLRKFIKLAAHLKE-QKNLNSFFAVMFGLSNSAISRLAHTWERLph-kvRKLYSALERLLdpswNHRVYRLALTk 767  Norway rat
7657261    782 lkRMKIIKHFIKIALHCRE-CKNFNSMFAIISGLNLAPVARLRTTWEKLpn-kyEKLFQDLQDLFdpsrNMAKYRNVLNs 859  human
5032025    269 qlRAEVFIKFIQVAQKLHQ-LQNFNTLMAVIGGLCHSSISRLKETSSHVph-eiNKVLGEMTELLsssrNYDNYRRAYGe 346  human
6665669    959 qkRAKLIKKFIKVARYCRD-LRNFNSMFAIMSGLDKPAVRRLHSSWERVss-kyIRMLDEIHQLVdpsrNMSKYRQHLAe 1036 Caenorhabditis e...
7512120    630 reRVDMLNTFIQVANELVHsMGNVFGFSAIMHGLTCPQVSSLDISWESLh----RKYTNNAVTYDk---KLRPLLRYLDe 702  Halocynthia roretzi
7499779    246 keRAEILVKFVHVAKHLRK-INNFNTLMSVVGGITHSSVARLAKTYAVLsn-diKKELTQLTNLLsaqhNFCEYRKALGa 323  Caenorhabditis e...
Feature 1                        ###  ### ### ####                 #   #                       
1BKD_S     317 i-----------npPCVPFFGIYLTNILKTEEGNPEvlkrhgkelINFSKRRKVAEITGEIQQYQN--QPYclrv---es 380  human
5901914    916 l-----------epPLIPFMPLLIKDMTFTHEGNKTfid----nlVNFEKMRMIANTARTVRYYRS--QPFnpdaa-qan 977  human
6912456    489 m-----------kpPKIPFMPLLLKDVTFIHEGNKTfld----nlVNFEKLHMIADTVRTLRHCRT--NQFgdlspkehq 551  human
7506314    482 aqwradsargnqqkIVIPFFVLLLKDLFLIYHGHPRilp---nahLNFMAFNQLAEQLRDVIQWKStvCTFekn-----p 553  Caenorhabditis e...
4079657    768 l-----------spPVIPFMPLLLKDMTFIHEGNHTlve----nlINFEKMRMMARAVRMLHHCRSh-STApl------s 825  Norway rat
7657261    860 qn---------lqpPIIPLFPVIKKDLTFLHEGNDSkvd----glVNFEKLRMIAKEIRHVGRMAS--VNMdp------a 918  human
5032025    347 c-----------tdFKIPILGVHLKDLISLYEAMPDylg---dgkVNVHKLLALYNHISELVQLQEvaPPLean-----k 407  human
6665669   1037 va---------qepPVVPIYPVIKKDLTFAHDGNATyse----klINFEKLRLIAKSIRGVMKLSS--APYei------a 1095 Caenorhabditis e...
7512120    703 gkgq-----irhssVCIPHIMPFTRLLENPGPGIPHast---getAAKRAASFGSLLDRTISSLGNe-DTAslnst-grd 772  Halocynthia roretzi
7499779    324 cn----------kkFRIPIIGVHLKDLVAINCSGANfek---tkcISSDKLVKLSKLLSNFLVFNQ--KGHnlp-----e 383  Caenorhabditis e...
Feature 1                              #  ##    
1BKD_S     381 dIKRFFEnlnpmg---nsmekeFTDYLFNKSLE 410  human
5901914    978 kNHQDVRsyvrq-----lnvidNQRTLSQMSHR 1005 human
6912456    552 eLKSYVNhly---------vidSQQALFELSHR 575  human
7506314    554 qVLQYLLits----------vsGEKDSMLMSFE 576  Caenorhabditis elegans
4079657    826 pLRSRVShihed------sqasRISTCSEQSLS 852  Norway rat
7657261    919 lMFRTRKkkwrslg--slsqgsTNATVLDVAQT 949  human
5032025    408 dLVHLLTlsld--------lyyTEDEIYELSYA 432  human
6665669   1096 sMAERSGgvvm--------dalLHMNSFENSNV 1120 Caenorhabditis elegans
7512120    773 vVKADWWenrpnesfdsllghmNSGRLLIQHLD 805  Halocynthia roretzi
7499779    384 mNMDLINtlkvs-----ldiryNDDDIYELSLR 411  Caenorhabditis elegans

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