1WZC,3ZTW


Conserved Protein Domain Family
osmo_MPG_phos
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TIGR02461: osmo_MPG_phos 
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mannosyl-3-phosphoglycerate phosphatase
Members of this family are mannosyl-3-phosphoglycerate phosphatase (EC 3.1.3.70). It acts sequentially after mannosyl-3-phosphoglycerate synthase (EC 2.4.1.217) in a two-step pathway of biosynthesis of the compatible solute mannosylglycerate, a typical osmolyte of thermophiles.
Links
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Statistics
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PSSM-Id: 131514
Aligned: 8 rows
Threshold Bit Score: 277.814
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1WZC_A     4 LIFLDIDKTLIp--GYEPDPAKPIIEELKDMGFEIIFNSSKTRAEQEYYRKELEVETP---FISENGSAIFIPKGYFPFD 78  Pyrococcus horikoshii
Q8U381     4 VIFLDLDKTLLp--EYDPEPAIPIVEELKKKGFEIVFNSSKTRAEQEYYREKLNVKGP---FIVENGSAIYIPSNYFPFE 78  Pyrococcus furiosus...
AAP74553  10 VIFTDLDGTLLdlhTYDPGPAREAVARLQERGIPIVFCSSKTRAEQLSYRRQLGIRDP---FIVENGATIFIPRGYFTVP 86  Rhodothermus marinu...
AAO43098   2 IVFTDLDGTLLd-eRGELGPAREALERLRALGVPVVPVTAKTRKEV----EALGLEPP---FIVENGGGLYLPR---DWP 70  Thermus thermophilu...
Q9YDM7     9 VIFTDLDNTLVg-pGGEAGEAGEVYLEALDLGYRVVPVTSKSIYEIVELWDSIGVPPGeriALAESGGAIYGPRGSLARP 87  Aeropyrum pernix K1
AII59907 418 VIYTDLDGTLLsplTYSYSTALDALRLLKDKELPLVFCSAKTMGEQDLYRNELGIKDP---FITENGGAIFIPKDYFRLP 494 Dehalococcoides mcc...
O58690     4 LIFLDIDKTLIp--GYEPDPAKPIIEELKDMGFEIIFNSSKTRAEQEYYRKELEVETP---FISENGSAIFIPKGYFPFD 78  Pyrococcus horikosh...
3ZTW_A     2 IVFTDLDGTLLd-eRGELGPAREALERLRALGVPVVPVTAKTRKEV----EALGLEPP---FIVENGGGLYLPRD---WP 70  Thermus thermophilu...

1WZC_A    79 VK-GKEVGNYIVIELGIRVEKIREELK--------KLEN--IYG---LKYYGNSTKEEIEKFTGMPPELVPLAMEREYSE 144 Pyrococcus horikoshii
Q8U381    79 VP-GVKRGEYMVLELGVKVEEIRKALK--------ELEA--EYG---LKYYGNSTDEEIEKFTKLPKHLIPLAKDREYSE 144 Pyrococcus furiosus...
AAP74553  87 REaRPTSHGLEVIELGRPAAEIRRALR--------EIRK--ETGl-sFRGYHEMTVEEVAELTGLPPEAARRAMTREYSE 155 Rhodothermus marinu...
AAO43098  71 VRaGRPKGGYRVVSLAWPYRKVRARLR--------EAEA--LAGr-pILGYGDLTAEAVARLTGLSREAARRAKAREYDE 139 Thermus thermophilu...
Q9YDM7    88 TGfNSEVG-LEYTALGKPLASIDALLDs-------LAET---CG---AVRLSKADATEAQLITGLPRERAALAARREYLE 153 Aeropyrum pernix K1
AII59907 495 FAyDRVAGNYLVIELGMSYKDIRHILKkalaeactEIENseRAGnifITSFGDMSVEDVSRLTDLNLKQAELAKQREYSE 574 Dehalococcoides mcc...
O58690    79 VK-GKEVGNYIVIELGIRVEKIREELK--------KLEN--IYG---LKYYGNSTKEEIEKFTGMPPELVPLAMEREYSE 144 Pyrococcus horikosh...
3ZTW_A    71 VRaGRPKGGYRVVSLAWPYRKVRARLR--------EAEA--LAGr-pILGYGDLTAEAVARLTGLSREAARRAKAREYDE 139 Thermus thermophilu...

1WZC_A   145 TIFEWSR----DGWEEVLV----EGGFKVTMGSRFYTVHG-NSDKGKAAKILLDFYKR-LGQIESYAVGDSYNDFPMFEV 214 Pyrococcus horikoshii
Q8U381   145 TIFLWKR----EGWEKDLI----RKGFKVTMGSRFYAVHG-NSDKGKAAKLLLDLYKR-VDEVESYAVGDGENDFPMFDV 214 Pyrococcus furiosus...
AAP74553 156 TIIVDFGpadwQRFNAALV----AHGLVCFAGGRFHTVVGlGTDKGQAVHRLAELYRQqHGAILTVGLGDSPNDVPMLRA 231 Rhodothermus marinu...
AAO43098 140 TLVLCP-----EEVEAVLEal-eAVGLEWTHGGRFYHAAK-GADKGRAVARLRALWPDpEEARFAVGLGDSLNDLPLFRA 212 Thermus thermophilu...
Q9YDM7   154 VIWSRSQ----ECLDTILStalrYRELTYVHRAPRTVQIAaHRGKGMAIDAALQEPLLrPCAKVVVTAGDSSHDIPIIER 229 Aeropyrum pernix K1
AII59907 575 TVHIEGD----KRSTNIVLnhiqQNGLEYSFGGRFYEVTG-GNDKGKAIKVLNELFRLnFGNIHTFGLGDSENDYSMLET 649 Dehalococcoides mcc...
O58690   145 TIFEWSR----DGWEEVLV----EGGFKVTMGSRFYTVHG-NSDKGKAAKILLDFYKR-LGQIESYAVGDSYNDFPMFEV 214 Pyrococcus horikosh...
3ZTW_A   140 TLVLCP-----EEVEAVLEal-eAVGLEWTHGGRFYHAAK-GADKGRAVARLRALWPDpEEARFAVGLGDSLNDLPLFRA 212 Thermus thermophilu...

1WZC_A   215 VDKVFIVG 222 Pyrococcus horikoshii
Q8U381   215 VDFAFLIG 222 Pyrococcus furiosus DSM 3638
AAP74553 232 VDRPFLVQ 239 Rhodothermus marinus DSM 4252
AAO43098 213 VDLAVYVG 220 Thermus thermophilus HB27
Q9YDM7   230 GMLAFRVD 237 Aeropyrum pernix K1
AII59907 650 VDSPILVQ 657 Dehalococcoides mccartyi CG4
O58690   215 VDKAFIVG 222 Pyrococcus horikoshii OT3
3ZTW_A   213 VDLAVYVG 220 Thermus thermophilus HB27
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