1RE5


Conserved Protein Domain Family
protocat_pcaB

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TIGR02426: protocat_pcaB 
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3-carboxy-cis,cis-muconate cycloisomerase
Members of this family are 3-carboxy-cis,cis-muconate cycloisomerase, the enzyme the catalyzes the second step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other]
Statistics
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PSSM-Id: 274128
Aligned: 10 rows
Threshold Bit Score: 345.578
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1RE5_A         5 LFDAYFTAPA-MREIFSDRGRLQGMLDFEAALARAEASAG-LVPHSAVAAIEAACQa-ERYDTGALANAIATAGNSAIPL 81  Pseudomonas put...
BAC19109       5 LYSDLAGESA-AHRHLSDEAFLTGLFTVEAALSVAAARAGaLSDAEAATAVETIRN--YQPDLEEISRQSAEGANPTIPV 81  Corynebacterium...
AAM39688       7 LLGGLFGDPA-CDEVFDDAARVQAMLDFESALARAQAQCG-VIPQAAAQVIAAQCHa-VHYDLAALAQATALAGNPAIPL 83  Xanthomonas cam...
CAD15958       5 LLDRTFSTPA-MLAVWSDAATVRAMLDVEAALAQAEGEVG-VIPAQAVAPIRAVCAr-ATLDLEALGAAAAGAGNLAIPL 81  Ralstonia solan...
AAK24381       5 LRDRPASTPE-MLTAFSDEALLRAALTFETMLARAQADVG-LIPSDAAETIAIACAe-LP-DVVSLAEAAAHAGTLAIPL 80  Caulobacter cre...
tigr:BRA0647  10 FLTGLFGDDEeISSLFTAYADIAAMLKFEAALAGAQADLG-IIPAHAAERIMSATEt-MEPDLAQLEHGTARDGVVVPTL 87  Brucella suis 1330
AAN67002       5 LFDAYFTAPA-MREIFSDRGRLQGMLDFEAALARAEASAG-LVPHSAVAAIEAACQa-ERYDVGALANAIATAGNSAIPL 81  Pseudomonas put...
WP_010973940  10 FLSGLFGDSE-IVELFSARADIDAMIRFETALAQAQVGTG-IISEDVAKAIVSGLSe-FAADMTALRHGVAKDGVVVPEL 86  Agrobacterium f...
WP_011728464   2 tdllWPGDHR-AGDLMSDRAFFDAMVAVENAWLNLLVDIG-PAPQKARVDLCALSS---AGDVETVAAGAESDGNPVVGL 76  Mycobacterium s...
WP_011031114  21 LAPGWTGSPA-A-SATGDRAYLRALLDAEAALTRAQAALG-LAPAEAADAVGAVAAdpAAFDARSLAERARDGGNPVIPL 97  Streptomyces co...
1RE5_A        82 VKALGKVIatgvpEAEryVHLGATSQDAMDTGLVLQLRDALDLIEADLGKLADTLSQQALKHADTPLVGRTWLQHATPVT 161 Pseudomonas put...
BAC19109      82 VKALKAID-----PTG--IHPGATSQDIIDTSLMLCLRDATGEIIADLGELAELLAELTRTHRDTPMMAHTLGQQAVPTT 154 Corynebacterium...
AAM39688      84 IKELTRQVaahdvDAArwVHWGATSQDVIDTGSVLQLRAAFDLLLPRLDALCACLATLAARERATGLPGRTLLQQAVPVT 163 Xanthomonas cam...
CAD15958      82 VKQLTAAVaqhdeLAAryVHWGATSQDIIDTGLMLQWRQAAALLDADLRQLADALAALARVHRDTPMVARTWLQQALPTT 161 Ralstonia solan...
AAK24381      81 VALIRERIad--pEVAklVHKGATSQDLADTALMLQAKTGAALVLRDASRLAQALAVLAQRHAATPMLGRTLLQAAQPIT 158 Caulobacter cre...
tigr:BRA0647  88 VRNLRKTVg---eDVAahVHFGATSQDVIDTSLMLRLARVRDILVARIEQLSERFNWLETTFGQNDLTAYTRMQPAISTT 164 Brucella suis 1330
AAN67002      82 VKALGKVIatgvpEAEryVHLGATSQDAMDTGLVLQLRDALDLIEADLGKLADTLSQQALKHADTPLVGRTWLQHATPVT 161 Pseudomonas put...
WP_010973940  87 VRQMRAAVa---gKAAekVHFGATSQDVIDTSLMLRLKMATEIIAARLGRLIDALGDIAARDGHNALTGYTRMQAAIGIT 163 Agrobacterium f...
WP_011728464  77 VALLRERTg---gEAArwLHRGLTSQDVVDTALMMCLRDALSAVHDEMATHVRILLDLVESHRKSPMTARTLTQPALPST 153 Mycobacterium s...
WP_011031114  98 VADLTKAVg---ePYGpyVHRGATSQDILDTATMLVAARTLDLLLPDLARTERALARLAAEHRDTPMPGRTLTQHAVPTV 174 Streptomyces co...
1RE5_A       162 LGMKLAGVLGALTRHRQRLQELRprlLVLQFGGASGSLAA-LGSKA-----MPVAEALAEQLKLTLPEQPWHTQRDRLVE 235 Pseudomonas put...
BAC19109     155 VGCITAGWLQAVLRSRAALQELR---FEVSYGGAAGTMTA-THPHG-----FAIQDELAAELGLHNSGLVWHSDRIPVTT 225 Corynebacterium...
AAM39688     164 FGLKAAGWLDALQRARRRLHTARteaLVLQFGGAAGTLAA-LETRG-----LEVAQALAHTLQLPLPALPWHTARDRLVE 237 Xanthomonas cam...
CAD15958     162 FGRKVAGWLEAVHRAQDRLAALRahvPALQFGGAAGTLAS-LGTQG-----RAVAQALAQALDLPLPAASWHGEQDRIAD 235 Ralstonia solan...
AAK24381     159 FGLKAAGWLQGVASALARFER-EtgaIQMQLGGATGSLAG-LDGRA-----GDVAERLAARLGLPAPETPWHARREGLAG 231 Caulobacter cre...
tigr:BRA0647 165 VADRVESWRAPFSDYAQRLAALQ---FPLQFGGAAGTLEKfVGKGA------KLRAELAKRLGLED-RPQWHSQRAFIAD 234 Brucella suis 1330
AAN67002     162 LGMKLAGVLGALTRHRQRLQELRprlLVLQFGGASGSLAA-LGSKA-----MPVAEALAEQLKLTLPEQPWHTQRDRLVE 235 Pseudomonas put...
WP_010973940 164 VADRAASWIAPLERHLLRLETFAqsgFALQFGGAAGTLEK-LGDNA-----GAVRADLAMRLGLAD-KQQWQSQRDGIAE 236 Agrobacterium f...
WP_011728464 154 AAAKFANWLSGVLDAADALAAVPw--LPVQLGGAVGTHAAtTELVGspdeaLTLADALAGAVGLTT-AAPWHTTRAVVTR 230 Mycobacterium s...
WP_011031114 175 FGLKAAGWRALVLDARDRITAVRd-aLPAQLGGAAGTLAA-FEAYGat-dpTALPAAYAGELGLRAPVLPWHTLRTPIAD 251 Streptomyces co...
1RE5_A       236 FASVLGLVAGSLGKFGRDISLLMQTEAGEVFE-PSApgkGGSSTMPHKRNPVGAAVLIGAATRVPGLLSTLFAA-MPQEH 313 Pseudomonas put...
BAC19109     226 IAAALATAAGAVRKIAGDVIFLSASEISELRE-AQP---GGSSAMPHKANPAAAIACDGYARRVPGLLATLFDA-LDCRL 300 Corynebacterium...
AAM39688     238 VGCAFALLAGSLGKIGGDVVLLMQSEVGEAFEpAAAg-kGGSSAMPHKRNPVAGVVAVAAAARVPGLVATLFAT-MAQPH 315 Xanthomonas cam...
CAD15958     236 IGAALALLTGTLGHMARDLSLMMQTEVGEVAEpAGAg-kGGSSTMPHKRNPVGCATVLAAATRMPGLAATLLAA-LPQEH 313 Ralstonia solan...
AAK24381     232 LASSLAILTGAVGKIAGDIALMAQTEVAEAFEpKVVg-rGGSSTMAHKRNPTGCQVALSASIRAPHLAATILSA-LPQQH 309 Caulobacter cre...
tigr:BRA0647 235 FGHLLSLVTGSLGKFGQDIALMAELRDEISLS--GG---GGSSAMPHKQNPVRAELLVTLARFNAVQVSGLHQA-MVHEQ 308 Brucella suis 1330
AAN67002     236 FASVLGLVAGSLGKFGRDISLLMQTEAGEVFEpSAPg-kGGSSTMPHKRNPVGAAVLIGAATRVPGLLSTLFAA-MPQEH 313 Pseudomonas put...
WP_010973940 237 FGNILSLVTGTLGKFGQDIALMAEIGTEIRLS--GG---GGSSAMPHKQNPVNAETLAALARFNAVQISALHQS-LVHEQ 310 Agrobacterium f...
WP_011728464 231 AGDALVGCCDACGHIAADVAVGSRAEIGELVE-GSG---GGSSTMPHKRNPVLSVLIRRAALAAPALGATLHAAsAASVD 306 Mycobacterium s...
WP_011031114 252 LAGTLAFTAGALGKIAVDVLTLSRTETGEVAE-GGG---GGSSAMPHKANPVRSTLIAAAARRAPQLAATLYGS-LAAED 326 Streptomyces co...
1RE5_A       314 ERSLGLWHAEWETLPDICCLVSGALRQAQVIAEGM 348 Pseudomonas putida KT2440
BAC19109     301 QRGTGSWHAEWQTIRELAAATASAVGRCRRSIDGI 335 Corynebacterium efficiens YS-314
AAM39688     316 ERAAGQWHAEWETLPEIVRLTAGSLAQMQACLAGL 350 Xanthomonas campestris pv. campestris str. ATCC 33913
CAD15958     314 ERALGGWQAQWATLREMACLAAGALDRMRELIAGL 348 Ralstonia solanacearum GMI1000
AAK24381     310 ERGLGGWQVEGPVLAELFELAHGALAAMAIVVEGL 344 Caulobacter crescentus CB15
tigr:BRA0647 309 ERSGTAWMLEWMILPPVVAATGAALKAALVLSDNI 343 Brucella suis 1330
AAN67002     314 ERSLGLWHAEWETLPDICCLVSGALRQAQVIAEGM 348 Pseudomonas putida KT2440
WP_010973940 311 ERSGAGWMLEWLSLPQMVTATGASLLIAERLAAQI 345 Agrobacterium fabrum
WP_011728464 307 ERSDGGWHAEWAALRTLTRRTVVAMRQTSDLLTGL 341 Mycobacterium smegmatis
WP_011031114 327 ERPAGAWHAEWEPLRDLLRLTGGAARDAAELAEGL 361 Streptomyces coelicolor
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