Conserved Protein Domain Family
cztS_silS_copS

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TIGR01386: cztS_silS_copS 
heavy metal sensor kinase
Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Statistics
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PSSM-Id: 273593
Aligned: 8 rows
Threshold Bit Score: 529.652
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9ZHD4         9 PFSLALRLTFFISLSTILAFIAFTWFMLHSVEKHFAEQDVSDLQQISTTLSRILQSP-ADPDe---KK-VSKIKESiASY 83  Salmonella ente...
O31396         7 PRTLRARLTALIILSTAATLALSGVALYSALHNRLVGMSSYEMSATLAAMRTHLANV-ANVDdi-pRKsDLWIDQL-HGH 83  Burkholderia ps...
AAG04827      10 GMSLSTRLAGMFAGAAVVIFALIGTMLYCILDRQTERLQQGEVDVRFNMVSRMLDHP--DLAerwpHL-QGKLDNLsQEY 86  Pseudomonas aer...
Q47457         4 KISLTTRLSLIFSAVMLTVWWLSSFILISTLNDYFDNQDRDFLTGKLQLTEEFLKTEtFRNKtdikSL-SEKINDAmVGH 82  Escherichia coli
CAA67087       9 PLSLTRRLGLFFALVLSIALASMGAFAYYSLAAQLEARDDEVVKGKLEQVEHFLREV--DGVqgvpAA-QHRFDDLvRGY 85  Cupriavidus met...
WP_017149092   4 PGRLSLRLALLVGALGALLALALGAMAHWNLGRELEARERENLQLKLEQIRHSLEDD-LDLRsdpaVQ-AHALQDQlVAH 81  Pseudomonas aer...
WP_003162386   8 RMSLGVRLSLLFAACTAAVSLIAGLIFSRAIDEHFVELDHMAMSAKLAVFRDELRGL-GSEQqmrrRE-AELLREL-ARH 84  Pseudomonas aer...
WP_003099516   4 RRSLTLYAALLFAAVAALVVSAVGFYLYRSVEEAMLRRSDVMVAGRVEHFRNLLRDN-LTLAel-kAR-PRLFENMlGNE 80  Pseudomonas
Q9ZHD4        84 RNVALLLLNPRGEVLYSSAQGaalRPAVNSADFSEHS-RArdvflwtvedtaramdtgsgmkmetyRIIASSGQATFQGK 162 Salmonella ente...
O31396        84 QNLDLAIYDTDGRLRFATRGF---VAPRPALGAPQTR-VPasaap-----------------agatFSYLADDAPLRGGN 142 Burkholderia ps...
AAG04827      87 ELIRFWIDSDDPRYHYGRFSEp-vQRLIADGAGRYEL-ELpe----------------------hrYALTARVGVLPARE 142 Pseudomonas aer...
Q47457        83 NGLFISIKNMENEKIVELYAKnsvVPAVLLNKSGDIL-DYmiqtee---------------nntvyRSISRRVAVTPEQG 146 Escherichia coli
CAA67087      86 SDLIVRVTALDGRLLF-----------RTGNDALLEGtDQaavt-------------------gksSLMFQSADAVLGRD 135 Cupriavidus met...
WP_017149092  82 SGLHLSILDSRSGQPL-MSFGdqaAASVAANRALLAR-LQadarqpvf-----------qswstgnDQRLLSIGASMRMK 148 Pseudomonas aer...
WP_003162386  85 PDLGLRLNGPDGNLWFERl-----PQPAHPGLPANRE-L---------------------------------GAPLEPGN 125 Pseudomonas aer...
WP_003099516  81 QDILLLGQPGEAPIVAVNPRHerlPSLRVVAAGQALN-PSvvhaa-----------------lthdGIPMRVLAAEVLVG 142 Pseudomonas
Q9ZHD4       163 QQ-NYVMLTGLSINFHLHYLDALKKNLIAIAVVISLLIVLIIRIAVRQGHLPLRNVSNAIKNITSENLDARLEPTRVPIE 241 Salmonella ente...
O31396       143 PR-TARIVVQYDGKNDHALLRAYAYTVVVIEVLAVVLTAALAYGIAMLGLSPLRRLVARAEQMSSSRLAQPLPELDTSGE 221 Burkholderia ps...
AAG04827     143 GRpRLTYVTAIDSAAFHEARTSTLKWLLGLSALGVLLASLLGHWIARLGLWPVHRLSEEARRISPRQLSQRLQLSPLPAE 222 Pseudomonas aer...
Q47457       147 KSkHVIITVATDTGYHTLLMDKLSTWLFWFNIGLVFISVFLGWLTTRIGLKPLREMTSLASSMTVHSLDQRLNPDLAPPE 226 Escherichia coli
CAA67087     136 Gt-RATVFVAKSGEDRKQVTARFRTTLVLGTTVGVILTALVGAAITRRELEPAHVLIKQINRISVERLSYRVDMPPKPTE 214 Cupriavidus met...
WP_017149092 149 NGtPVQVLLSSERNADERLLDGFLRATLLALPFLLPLIALAAWWVVRAGLEPLNRFRRVAAQVSPQDLSYRIPEQNLPRE 228 Pseudomonas aer...
WP_003162386 126 DAsP-RLTVILDISHHQHFLQRMRQLIWLTMSLSALATALLGAWATGASLAPLRRMREVAARVSANSLTTRLDASRMPEE 204 Pseudomonas aer...
WP_003099516 143 GRePLQITAAHLLLGETRMLAQYRDRVIAAVLLAFLGTALLGWLVLRHGLRPLRTLAAKAAEIHPTSLDTRLDVAAAPAE 222 Pseudomonas
Q9ZHD4       242 LEQLVISFNHMIGKIEDVFTRQANFSADIAHEIRTPITNLVTQTEIALSQDRTQKELEDVLYSSLEEYNRMTKMVSDMLF 321 Salmonella ente...
O31396       222 LKEMEHAFNAMLKRLDESFVRLSQFSSNLAHDMRTPLTNLLAEAQVALSKPRTADEYRDVIESSIDEYQRLSRMIEDMLF 301 Burkholderia ps...
AAG04827     223 LRELVGAFNGALDRLEQAYVRLESFNADVAHELRTPLTNLIGQTQVALSRERSGEHYEEVLQSNLEELERLRAIVNDMLF 302 Pseudomonas aer...
Q47457       227 ISETMQEFNNMFDRLEGAFRKLSDFSSDIAHELRTPVSNLMMQTQFALAKERDVSHYREILFANLEELKRLSRMTSDMLF 306 Escherichia coli
CAA67087     215 VRDIASAFNAMLQRLEDGYQKLSRFSADLAHDLRTPLNNLIGHAEVALSRDRTGPEYVALVEESLVEYQRLARMIDAMLF 294 Cupriavidus met...
WP_017149092 229 LDSLARSFNHMLGRLEDGVRQLSQFSDDLAHELRAPICNLLVRNQVLLSQHRDGAAYREALESNAEELERLSRIVTDMLF 308 Pseudomonas aer...
WP_003162386 205 LRGLAGELNAMLARLEEAFQRLSAFSADIAHELRTPLTSLLTQTQVVLSRPRSLEDYREALHGNLEELERLTAMVNDMLL 284 Pseudomonas aer...
WP_003099516 223 LQQVAQSFNAMLERLDDGYQRLQQFSADLAHEIRTPIGSLMGHGQVALRQPRSNEEYQALIASNQEELERIARMVESILF 302 Pseudomonas
Q9ZHD4       322 LAQADNNQLIPDRVRFDLQSQNSlKVFRVFsEALGPKETpiLLLKFNGMpCLVEGDPQMFRRAINNLLSNALRYTPEGQA 401 Salmonella ente...
O31396       302 LARSDNAQSHLAIRTLDAAAQAE-RVAGYY-EPMAEDAD--VRIVVRGK-AEVRADALLYHRALSNLISNALNHAPRGST 376 Burkholderia ps...
AAG04827     303 LARADQGRLACEREETSLAGEIA-TTVDFL-EVIFDEAG--VGIEVRGE-ARALVERALFQRAVTNLLYNAAQHTAAGGT 377 Pseudomonas aer...
Q47457       307 LARSEHGLLRLDKHDVDLAAELN-ELRELF-EPLADETG--KTITVEGE-GVVAGDSDMLRRAFSNLLSNAIKYSPDNTC 381 Escherichia coli
CAA67087     295 LARADSANVALELTELQLNAELR-KLSAYF-SVLAEERS--VVIRVSGD-ATLVADAILFQRAINNVLSNAVRHAWPNSM 369 Cupriavidus met...
WP_017149092 309 LVQVDNPAIQAQFGCVALHEQAA-KVIDLY-EMVAEDKG--VELRLSGN-GFAHGDNLMIQRAISNLVSNAVRHTPQGGR 383 Pseudomonas aer...
WP_003162386 285 LAKADHGLLAPSRQALDLGAEVD-SLLEFY-QPLAEDRD--IRLLREGS-LSLPGDRGMLRRVLANLLDNALRFTADGGE 359 Pseudomonas aer...
WP_003099516 303 LARADDVRAAVERSRLDLGEELR-RQAEYF-EGLAEERG--LSLDVQVS-GQLRADPQLFRRALSNLLANAIRYASADSL 377 Pseudomonas
Q9ZHD4       402 ITVSIREQESFFDLVIENPGKPIPEEHLSRLFDRFYRVDPSRQR-KGEGSGIGLAIVKSIVEAHHGRVQVES-D-VHSTR 478 Salmonella ente...
O31396       377 ITIECAQAADAATISVSDTGRGIEAPHRERIFERFYRVDPARHN-SASGTGLGLAIVRSIMENHGGTCGVDSeP-HVRTT 454 Burkholderia ps...
AAG04827     378 LRVGVERRGDEVRVAVSNPGVPIADEHRRHLFERFYRVDAARSN-SEANHGLGLSIVKAVASMHGGSVFVDS-A-DGWNT 454 Pseudomonas aer...
Q47457       382 TAIHLERDSDCVNVMITNTMSGQVPANLERLFDRFYRADSSRFY-NTEGAGLGLSITRSIIHAHGGELSAEQ-Q-GREIV 458 Escherichia coli
CAA67087     370 IDLVVRRDR-HCCIDITNVGDPIPERELSLIFDRFFRGDRARSN-SSQSTGLGLAIVLSIMELHGGDASAVSgL-DGKTR 446 Cupriavidus met...
WP_017149092 384 IDVRIGERAGHTEVRVSNDGPGIPPEYLPHLFERFYRRAGRQTG-AQAGTGLGLAIVQSIMAYHGGRAEAESvP-QQKTH 461 Pseudomonas aer...
WP_003162386 360 IRIRLGDR----RLSVENQGPAIPPERLPRLFDRFYRADPARREgQGEHAGLGLAICRSIVQAHGGEIRCES-A-DGWTR 433 Pseudomonas aer...
WP_003099516 378 IEVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFYRGDAARSD-AQS-SGLGLAIVQAIMRLHGGRAEASA-PaPGRIR 454 Pseudomonas
Q9ZHD4       479 FILSVP 484 Salmonella enterica subsp. enterica serovar Typhimurium
O31396       455 FWLKFP 460 Burkholderia pseudomallei K96243
AAG04827     455 FGFTVL 460 Pseudomonas aeruginosa PAO1
Q47457       459 FKVRLL 464 Escherichia coli
CAA67087     447 FTLRFP 452 Cupriavidus metallidurans CH34
WP_017149092 462 LRLLFP 467 Pseudomonas aeruginosa
WP_003162386 434 FVIDFA 439 Pseudomonas aeruginosa
WP_003099516 455 FDLAFP 460 Pseudomonas
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