4EG2


Conserved Protein Domain Family
cyt_deam_dimer
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TIGR01355: cyt_deam_dimer 
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cytidine deaminase, homodimeric
This homodimeric zinc metalloprotein is found in Arabidopis and some Proteobacteria. A related, homotetrameric form with a much smaller subunit is found most bacteria and in animals. Both types may act on deoxycytidine as well as cytidine. [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]
Links
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Statistics
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PSSM-Id: 273573
Aligned: 7 rows
Threshold Bit Score: 382.64
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4EG2_A        32 FDATFSAEQYQQLLtlsgLEDADLRVALLPIAAAYSYAPISEFYVGAIVRGISGRLYLGANXEFTGAQLGQTVHAEQCAI 111 Vibrio cholerae
AAC69565      29 YKFVFTAKEAASEG----VTEPIRLPKLIRKAMSLARGPISKYKVGAVGRASSGRVYLGVNVEFPGLPLHHSIHPEQFLV 104 thale cress
AAC69569       5 YKFVFTAEQAASEG----VTDHKKLPKLIRKARNLVKAPS---KVGAVGRASSGRFYLGVNVEFKGLLPHFSIHAEQFLI 77  thale cress
CAA06671       4 PSFVIQSKEAESAAkqlgVSVIQLLPSLVKPAQSYARTPISKFNVAVVGLGSSGRIFLGVNVEFPNLPLHHSIHAEQFLV 83  thale cress
P44325        28 WAGFLNYSQVQQLChnfeLTTLKLAMHLLPLAASYSHTAISHFNVGAIAIGEQGDFYFGANQEFANSAIQQTIHAEQSAI 107 Haemophilus inf...
WP_001245905  29 FDATFSAEQYQQLLtlsgLEDADLRVALLPIAAAYSYAPISEFYVGAIVRGISGRLYLGANMEFTGAQLGQTVHAEQCAI 108 Vibrio cholerae
AAD39264       7 PYAALTPTEAESSG----PFEPETLLPLINRALPLAQALPSQSPLVAVGRGSSGRTFLGVNVELPGLSPLHSIHAGQFLV 82  thale cress

4EG2_A       112 SHAWXKGEKGVADITIN--------FSPCGHCRQFXNELTTASSLKIQLPKRAAK-------------TLQEYLPES-FG 169 Vibrio cholerae
AAC69565     105 TNLALNSEKGLRQLAVAissdciefGAPCGNCRQFLMETSNELDIKILLKSKHEAegs--------fsSLKLLLPYR-FT 175 thale cress
AAC69569      78 ANLALNSEPKLTHLAVShng--tvfQDPCYDCTHFLKEINNAHQIEILIKNAHGRdgs--------fkSLESHMPDE-FG 146 thale cress
CAA06671      84 TNLTLNGERHLNFFAVS--------AAPCGHCRQFLQEIRDAPEIKILITDPNNSadsdsaadsdgflRLGSFLPHR-FG 154 thale cress
P44325       108 SHAWLRNERRISDMVVN--------YTPCGHCRQFMNELHGAEKISIHLPHSQNN-------------PLHSYLPDA-FG 165 Haemophilus inf...
WP_001245905 109 SHAWMKGEKGVADITIN--------FSPCGHCRQFMNELTTASSLKIQLPKRAAK-------------TLQEYLPES-FG 166 Vibrio cholerae
AAD39264      83 VHLALNNERTLNCLAFSsng--syfDPPCPHCCQLLQEIRNASSTKLLITDPSRQrd----------mSLSTYLPQKyFS 150 thale cress

4EG2_A       170 PADLGID--S-GLXSPVNHGKTSDDD---------------EELIQQALRAXNISHSPYTQNFSGVALKXRSGAIYLGAY 231 Vibrio cholerae
AAC69565     176 PDDVLPK--GsPLLLEKRDNCLTLSGsteei-----cssdcSHLKCKALAAANNSFSPYTESPSGVALQDDEGKWYRGWY 248 thale cress
AAC69569     147 SESILSA--EpSLLLMERDNCLALIDedsaaggissnadlcSFLKLEALKAANKSYAPYRKCPSGVALFC-EGEVYAGWY 223 thale cress
CAA06671     155 PDDLLGK--DhPLLLESHDNHLKISDldsicn---gntdssADLKQTALAAANRSYAPYSLCPSGVSLVDCDGKVYRGWY 229 thale cress
P44325       166 PKDLDIA--A-HLLAEENHDLVADHQd---------------dLVNQAILAANQSHCPYSNSPHGIAILFKNSDVVTGRY 227 Haemophilus inf...
WP_001245905 167 PADLGID--S-GLMSPVNHGKTSDDDe---------------eLIQQALRAMNISHSPYTQNFSGVALKMRSGAIYLGAY 228 Vibrio cholerae
AAD39264     151 LYNEVPKyfFaRLLDENRNNGLTLINpnpirdc--ldseicNHLGCRALKAANRSYAPYSKSPSGVALMDFQGRVYSGWS 228 thale cress

4EG2_A       232 AENAAFnPSLPPLQVALAQ--AXXXGESFEDIEAAALVESATGKISHLADTQATLEVIN-PDIPLSYLSL 298 Vibrio cholerae
AAC69565     249 IESVAYsPSLGPVQAALVDfvARSRGKGFNKIVEAVLVEKNNARVSQERTAKMILDTIAaPNCDFKVFHC 318 thale cress
AAC69569     224 IETVDRtISLGPVQAALVDfiARGEGKGFDKITGAVLVEKKDAKVGQEDTARKLLEKIAaPNCDFKVFHC 293 thale cress
CAA06671     230 MESAAYnPSMGPVQAALVDyvANGGGGGYERIVGAVLVEKEDAVVRQEHTARLLLETIS-PKCEFKVFHC 298 thale cress
P44325       228 AENAAFnPSLPALQTALNFayLN--DKKLSDIERIVMAEKAL-KLSHKTMAETLLSTLT--SVELEYYSL 292 Haemophilus influenzae Rd...
WP_001245905 229 AENAAFnPSLPPLQVALAQamMM--GESFEDIEAAALVESATGKISHLADTQATLEVIN-PDIPLSYLSL 295 Vibrio cholerae
AAD39264     229 IESVAN-PILGAAQAALVDfmTNGGGHEFNNIVRGFLVEKRDAKLSHLATAREILNKIAhFSFILRVLHC 297 thale cress
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