Conserved Protein Domain Family
fadh2_euk

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TIGR00677: fadh2_euk 
methylenetetrahydrofolate reductase, eukaryotic type
The enzyme activities methylenetetrahydrofolate reductase (EC 1.5.1.20) and 5,10-methylenetetrahydrofolate reductase (FADH) (EC 1.7.99.5) differ in that 1.5.1.20 (assigned in many eukaryotes) is defined to use NADP+ as an acceptor, while 1.7.99.5 (assigned in many bacteria) is flexible with respect to the acceptor; both convert 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. From a larger set of proteins assigned as 1.5.1.20 and 1.7.99.5, this model describes the subset of proteins found in eukaryotes and designated 1.5.1.20. This protein is an FAD-containing flavoprotein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]
Statistics
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PSSM-Id: 129760
View PSSM: TIGR00677
Aligned: 8 rows
Threshold Bit Score: 479.614
Threshold Setting Gi: 1709159
Created: 7-Oct-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAD55787   17 AFSFEFFPPKTEDGVENLFERMDRL-VSY-GPTFCDITW----GAGGSTADL-TLEIASRMQNVI-CVETMMHLTCTNMP 88  thale cress
AAD51733   17 AFSFEYFPPKTEEGVENLFERMDRM-VAH-GPSFCDITW----GAGGSTADL-TLEIANRMQNMV-CVETMMHLTCTNMP 88  Zea mays
Q10258     17 TYSYEFFPPKTSTGVQNLYNRIDRM-KTWgRPMFVDVTW----GAGGTSSEL-TPGIVNVIQTDF-EVDTCMHLTCTNMS 89  Schizosaccharomyce...
CAA63833   18 TYSFEYFVPKTTQGVQNLYDRMDRMyEAS-LPQFIDITW----NAGGGRLSH-LSTDLVATRQSVlGLETCMHLTCTNMP 91  baker's yeast
P46151     14 FISLEFFPPKTELGTRNLMERMHRM-TAL-DPLFITVTW----GAGGTTAEK-TLTLASLAQQTL-NIPVCMHLTCTNTE 85  Saccharomyces cere...
NP_566011  17 AFSFEFFPPKTEDGVDNLFERMDRM-VAY-GPTFCDITW----GAGGSTADL-TLDIASRMQNVV-CVESMMHLTCTNMP 88  thale cress
CAA96833   18 TYSFEYFVPKTTQGVQNLYDRMDRMyEAS-LPQFIDITW----NAGGGRLSHlSTDLVATAQSVL-GLETCMHLTCTNMP 91  baker's yeast
AAD17965   59 WFSLEFFPPRTAEGAVNLISRFDRM-AAG-GPLYIDVTWhpagDPGSDKETS-SMMIASTAVNYC-GLETILHMTCCRQR 134 human
AAD55787   89 IEKIDHALETIRSNGIQNVLALRGDPPHGQDKF---VQVEGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVieadg 165 thale cress
AAD51733   89 VEKIDHALETIKSNGIQNVLALRGDPPHGQDKF---VQVEGGFACALDLVQHIRAKYGDYFGITVAGYPEAHPDA----- 160 Zea mays
Q10258     90 TEMIDAALKRAHETGCRNILALRGD-PVKDTDW---TEGESGFRYASDLVRYIRTHYNDEFCIGVAGYPEGYSPD----- 160 Schizosaccharomyce...
CAA63833   92 ISMIDDALENAYHSGCQNILALRGDPPRDAENW---TPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPEL----- 163 baker's yeast
P46151     86 KAIIDDALDRCYNAGIRNILALRGD-PPIGEDWldsQSNESPFKYAVDLVRYIKQSYGDKFCVGVAAYPEGHCEG----- 159 Saccharomyces cere...
NP_566011  89 VEKIDHALETIRSNGIQNVLALRGDPPHGQDKF---VQVEGGFDCALDLVNHIRSKYGDYFGITVAGYPEAHPDVigeng 165 thale cress
CAA96833   92 ISMIDDALENAYHSGCQNILALRGDPPRDAENW---TPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPEL----- 163 baker's yeast
AAD17965  135 LEEITGHLHKAKQLGLKNIMALRGDP--IGDQW---EEEEGGFNYAVDLVKHIRSEFGDYFDICVAGYPKGHPEA----- 204 human
AAD55787  166 latpES--Y------QS---------DLAYLKKKVDAGADLIVTQLFYDTDIFLKFVNDCRQ-IGINCPIVPGIMPISNY 227 thale cress
AAD51733  161 ----IQ--G------EGgatleaysnDLAYLKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQ-IGITCPIVPGIMPINNY 227 Zea mays
Q10258    161 ----DD--I------DE---------SIKHLKLKVDEGADFIVTQMFYDVDNFIAWVDKVRA-AGINIPIFPGIMPIQAW 218 Schizosaccharomyce...
CAA63833  164 ----PNkdV------KL---------DLEYLSRR-STGGDFIITQMFYDVDNLLNWCSQVRA-AGMDVPIIPGIMPITTY 222 baker's yeast
P46151    160 ----EA--EgheqdpLK---------DLVYLKEKVEAGADFVITQLFYDVEKFLTFEMLFRErISQDLPLFPGLMPINSY 224 Saccharomyces cere...
NP_566011 166 lasnEA--Y------QS---------DLEYLKKKIDAGADLIVTQLFYDTDIFLKFVNDCRQ-IGISCPIVPGIMPINNY 227 thale cress
CAA96833  164 ----PNkdV------KL---------DLEYLSRR-STGGDFIITQMFYDVDNLLNWCSQVRA-AGMDVPIIPGIMPITTY 222 baker's yeast
AAD17965  205 ----GS--F------EA---------DLKHLKEKVSAGADFIITQLFFEADTFFRFVKACTD-MGITCPIVPGIFPIQGY 262 human
AAD55787  228 KGFLRMAGFCKTKIPAELTAAL-EPIKDNDEAVKAYGIHFATEMCKKILAH---G-ITSLHLYTLNVDKSAIGILMNLGL 302 thale cress
AAD51733  228 KGFLRMTGFCKTKIPSEITAAL-DPIKDNEEAVRQYGIHLGTEMCKKILAT---G-IKTLHLYTLNMDKSAIGILMNLGL 302 Zea mays
Q10258    219 DSFIRRAKWSGVKIPQHFMDTL-VPVKDDDEGVRERGVELIVEMCRKLIAS---G-ITRLHFYTMNLEKAVKMIIERLGL 293 Schizosaccharomyce...
CAA63833  223 AAFLRRIQWGQISIPQHFSSRL-DPIKDDDELVRDIGTNLIVEMCQKLLDS---GyVSHLHIYTMNLEKAPLMILERLNI 298 baker's yeast
P46151    225 LLFHRAAKLSHASIPPAILSRFpPEIQSDDNAVKSIGVDILIELIQEIYQRtsgR-IKGFHFYTLNLEKAIAQIVSQSPV 303 Saccharomyces cere...
NP_566011 228 RGFLRMTGFCKTKIPVEVMAAL-EPIKDNEEAVKAYGIHLGTEMCKKMLAH---G-VKSLHLYTLNMEKSALAILMNLGM 302 thale cress
CAA96833  223 AAFLRRIQWGQISIPQHFSSRL-DPIKDDDELVRDIGTNLIVEMCQKLLDS---GyVSHLHIYTMNLEKAPLMILERLNI 298 baker's yeast
AAD17965  263 HSLRQLVKLSKLEVPQEIKDVI-EPIKDNDAAIRNYGIELAVSLCQELLAS---GlVPGLHFYTLNREMATTEVLKRLGM 338 human
AAD55787  303 IDES 306 thale cress
AAD51733  303 IEES 306 Zea mays
Q10258    294 LDEN 297 Schizosaccharomyces pombe 972h-
CAA63833  299 LPTE 302 baker's yeast
P46151    304 LSHI 307 Saccharomyces cerevisiae S288c
NP_566011 303 IDES 306 thale cress
CAA96833  299 LPTE 302 baker's yeast
AAD17965  339 WTED 342 human
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