Conserved Protein Domain Family
PRK05776

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PRK05776: PRK05776 
DNA topoisomerase I; Provisional
Statistics
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PSSM-Id: 235602
Aligned: 23 rows
Threshold Bit Score: 1014.53
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
212223461   5 IIAEKPNVARKIAYALAEgRP--VRKTIGKVPYYEFTRDGKRIIVAPAVGHLFSLAPKTKtyGYPVFDIEWVPVYVAEKG 82 
14601630    1 MVAEKPKAAAKIAYALSD-GRgvLRCSEYGVPYWIVRRDGAAIVVAPSAGHLFGPHTDSR--GFPVFDFEWRPIFEFDRG 77 
126466161  57 VIAEKPKAANKIALALSR-NP--IRKSMYGIPYYLIKNRHSSIIVASAAGHLYGLHTDQY--GYPVFKYEWKPLYQIDPK 131
156936802   7 VIAEKPKAAEKIANALG--KP--IVKRKYGVPYWEL-TNGKKIVVVPAAGHLFGLAPLGK--GFPVFDYEWRPLYEIEKG 79 
218884347  17 VIAEKPKAAKKIASALSP-TH--NAKRIGSITIYEVDSYSSSIIIASSVGHLYQLHTSLR--GYPVYSYEWIPLHLTDPS 91 
14521628    4 VIAEKPNVARKIAGALSErRP--IRKTIFGVPYYEVFRDGKKLIVASAVGHLYGLAPKQDffGYPIFDIEWVPVYIAEKN 81 
14590513    4 IIAEKPNVARKIAGALSErRP--IKKSLFGVPYYEIFREGKKLIVASAVGHLYGLAPKRDvfGYPIFDIEWVPVYIAEKG 81 
305663582   9 VIAEKPKSAEKIAYALG--NP--KKYRINGVPVWFVMRGTSRFVIAPAAGHLYTLHTESK--GFPVFDYKWVPKYIVEPE 82 
302348228  16 IIAEKPKAADKIAHALG--SP--FRCAIGRVPIYILNVNGTNIVVVSSAGHMFGPSTGVE--GLPVTMIRWEPLWRFDRR 89 
296241915  26 VIAEKPKAARKIAEALSQ-RY--FVRNINDVTYFEIRDGPRQIIVASSVGHLYGLTTQEE--GYPVYTYQWVPLYVVEKK 100
212223461  83 KSYAKDYIKALATLAKRADEFVVACDYDTEGEVIGYTALKYACgvDPSKAKRMKFSALTKKDLLKAWYNLEsTINFGMAD 162
14601630   78 AGYLSKFYRMLSRILPGASLYVNACDYDIEGSVIGFKIIEAFG--DVNRARRMKFSTLAPQDIRRAYARME-RLDVEMIE 154
126466161 132 AKHTEKFIMVLSKLCSNADYYVNACDYDIEGSVIGYLIIYFHG--DLEKSLRAKFSSLTIEELRESFRKLT-SLDWEMIE 208
156936802  80 ASHTKKYIALISSLSPGSSLYVNACDYDVEGSVIGYIIIERFG--DPRRSKRMVFHALTPDEIRRAWNSLR-PLDWEMIN 156
218884347  92 KKYIREYLEVLGKLCRGVDYYVNACDYDIEGSVIGYLIIKFNG--DERKAFRARFSSLTIEELRKAFNNLT-RLDYEMIE 168
14521628   82 KDYAKDYIKALSVLAKRVKEFIVACDYDTEGEVIGYTALKYACgvDPSRAKRMKFSALTKRDLLNAWRNLEpTINFGMAN 161
14590513   82 KEYAREYIKALSVLAKRVREFIVACDYDTEGEVIGYTALKYACgvDPRVAKRMKFSALTKRDLLNAWRNLEpTINFGMAN 161
305663582  83 SIFTRKYLNVLSMLAKNAKEYINACDYDIEGSLIGYMIIKNIG--DIKRSKRAKFSSLTASEIVRAFNNLL-PLDYNMIE 159
302348228  90 SKYLRPYYEVLSRLVPKARYFINACDYDIEGSTIGYKIIEAFG--DKSRAKRMKFSSLTAAELRQAFRRLQ-PLDVNNAM 166
296241915 101 KAHSYNYLEALRKLCTTSNYFVNACDYDIEGSVIGYLIIKFNG--DPGRAYRAKFSSLTLSELREAFRRLT-QLDYEMIE 177
212223461 163 AGIARHVLDWYWGVNLSRALTSAIKRASGKWMVLSTGRVQGPTLKFLVDREKEIQNFKPTPYWVIKMVLEKNGQQYTAVY 242
14601630  155 AGMARSEMDWLWGINVSRALMEAARRAAGRRVILSAGRVQSPTLVEAYRRWREINLHVPKASVAVKITAEKGGGVFDARP 234
126466161 209 AGLCRHELDWIWGINISRALMSSVKIASGKRVILSAGRVQTPTLRYVVEKDIERRLFIPLPQYSLSINIFKNNYEIHVEY 288
156936802 157 AGLARHELDWIWGINVSRALMHAYRVATGKSKSLSAGRVQSPTLKEVVERELAVQCFVPEPYFSVSLSAKGVSLEPTLKF 236
218884347 169 AGLCRHELDWIWGINVSRALMKAVEDAVGERIILSAGRVQTPTLKYVVDKVVERNLFIPLPQYNINITVEKNGEKIRLEY 248
14521628  162 AGIARHVLDWYWGVNLSRALTHAIKRASGKWVVLSTGRVQGPTLKFLVEREREIQSFVPKPYWVIKLVIEKNGQKLVANY 241
14590513  162 AGIARHILDWYWGVNLSRALTHAIKKASGKWVVLSTGRVQGPTLKFLVEREREIQSFVPRPYWVIKLIFEKNGQKFTANY 241
305663582 160 AGYCRHILDWLWGINVSRMLMSIYRSVFNEKRILSAGRVQSPTLSYVVNIDLQRKTHVPVPYAYPSIKIFIDNKIFKLIP 239
302348228 167 AGIARAELDWLWGINISRLLMKSYREVTGERLSLSAGRVQTPTLAEAIRRWVKINTHVPIPQPSLTARLLHKGVEFTAYP 246
296241915 178 AGLCRHELDWLWGINVSRAIMRTVESFSKKKIILSAGRVQTPTLKYVSDIEKERNLFIPIPVYSVVPTIVKDGVKITLEL 257
212223461 243 EKERILDENEAKRIVEEAKK-GPAFVEKVDVKQQNRHPPVPFDLGTLQREAYSAFGYSPKKTLELAQKLYERGLTSYPRT 321
14601630  235 HGWKPQSLETARSIKSELRKnPWLAVEEVRSERSILRPPPAFNLGDLQKEANRILGLPPLRTQSIAEELYLEALISYPRT 314
126466161 289 KGKSVETKKNAKEIIDEIKRtGYLIVKKYEEKIYTLNPPPAFNLGDLQEEAARIYGFSPYKTQSIAEKLYLDALISYPRT 368
156936802 237 -----ETKDEADHFISNCLG----KVVDVIVNDERLSPPHPFNLPDLQMEAARLYGFSPSKTQSIAEELYLDAYISYPRT 307
218884347 249 TGNPVEKERDARDIVEKIRGyKYLIVSKVEKKHHILHPPPPFNLGDLQKEAARLYGFSPAETQSIAEQLYLDALISYPRT 328
14521628  242 EKDKIWSEEEAKKIVTEVKK-SKARVSNIEVKRQKRNPPVPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFTSYPRT 320
14590513  242 EKDKIWEEEEGKRIVLEVKK-SIPRVSNVEIKRQKRTPPHPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFSSYPRT 320
305663582 240 IDSPFNSLSDAKEYLENIKRdPRATVLDIIVRDERIEPPHPFNLPDLQSEAHRIYGFTPYKTQKLAEDLYLEALISYPRT 319
302348228 247 LGWSVSTVKEAREVAKEVKEgMYMEVISLSRASESVRPPPPFNLTDLQKEAARIYGLSPYKTQEVAEDLYLAALISYPRT 326
296241915 258 INSPIRTKKDAYALAERIRReGFLTVESYVEHTTSVAPPPPFNLGDLQEEAARIYGYSPSKTQSIAEQLYLDALISYPRT 337
212223461 322 SSQKLPKNLNFRSILQNLAKLPeYKPFAHEL--LGKERLKPVEGKKDDPAHPAIYPTGElPkPGE-LTKDEANLYDLIVR 398
14601630  315 NSQKLPPSINYRAILDKLAHGP-LGREARELlkETGGVLRPVQGSKDDPAHPAIHPTGE-K-PSQrLSKEHMAVYELIVR 391
126466161 369 NSQKLPPTLNYKAIMNKLSRINnYKELVSNLlvETKGVLKPVQGSKDDPAHPAIYPTGV-K-PKD-LGKDEWKIYDLIVR 445
156936802 308 NSQKYPKDLDYANILKGIASVPqYRPLTKALfkETRGRFSPNNGPKDDPAHPAIYPTGK-P-PKN-LSPDHMKVYDLIVR 384
218884347 329 NSQKLPPTLDYRRILENISSIKsYRNLVESLisETKGVLTPVEGEKEDPAHPAIYPTGV-V-PGR-LTEKQWAIYDLIVK 405
14521628  321 ESQKLPKNLNFRLIIQNISRMPqYRPYAHLLlgMP--ELKPVEGKKEDPAHPAIYPTGEiPgPGD-LSKDEEKLYDMIVR 397
14590513  321 ESQKLPRNINFRMIIQNLAKMPqYRPYAHILlgL--PELKPVEGKKEDPAHPAIYPTGEiPrPGD-LTKDEEKLYDMIVR 397
305663582 320 NSQKLPPTLNNREILEKLSQNIvYRTLVKTLlaETRGILRPNNGPKEDPAHPAIYPTGEgT-LKG-LSKDHIKLYDLIVR 397
302348228 327 NSEKLPPTLNYREVLDSIGRQPkYRGLVGDLlrETGGVLRPREGPADDPAHPAIYPTGE-Q-PTR-LDRVHETVYDLIVR 403
296241915 338 NSQKLPSGLDFKSLLTKISQISnYSALVSDLlkETKGYLKPVEGDKEDPAHPAIYPTGV-R-PVK-LSSEQWAVYDLIVR 414
212223461 399 RFLALFMEPAVREIMKVIINsnGH---RFILSGARTIKEGWLKVYgKYVKFDEAI--LPAFKEGEPVKVLQIKREKKKTK 473
14601630  392 RFLAAFSREAIVSKSSVLLR--DFqgrVWRAEGLRVEDLGWLKYY-HYSTPGEKP--MPPLDRGDKARVVRVDVRVEWSQ 466
126466161 446 RFLAAFASKARISHRIVYLEypKDpsmVFQASGQKILDLGWLRYY-PFSKPEERF--LPKFQYGEKVKIVKASIRKTYTK 522
156936802 385 RFMATLASESVYEVTKVVIEvnGQ---TFKAVGRRVKWKGWTLYY-PFSAPQEKS--LPSFTKGESLQV-KCTRRLQYTK 457
218884347 406 RFLAVFAPPAKIVYYVVKATtpSHe-yVFETKGQVIEEYGWLKYY-NFHNYHAGK--IPVLKEGELLNIVKATASESYTK 481
14521628  398 RFLALFMEPAVRESVKVTILag---phKFMLSGARTVKQGWLSVYgKYIKFDEVT--LPEFFIGERVRVLQVRREKKKTK 472
14590513  398 RFLAVFMEPAIRESVKVTIRagPH---KFFLSGGRTVKKGWLSVYgKYVKFEEVT--LPEFFIGERIKVIQVKREKKKTK 472
305663582 398 RYLATFANPAVVQYVRIEFIvhGR---RYYLSTNIVRSRGWLQYY-PYIHFNGEEisLKLLRKGLQIPIHEAKIVIHFTK 473
302348228 404 RFMAAFAPPATLSTVSAVLTdvKAr--RWEARGLNVAERGWLKYY-PFHKFDESQ--LPTLNRGDRPLVRSITVKVSWSG 478
296241915 415 RFLAAFAGNAIIYRSTAKFAlpGEn-iVFQATGQGIEDLGWYKYY-PFHKPSVKV--LPRFRNGERVEVVEVSVKTAYTR 490
212223461 474 PPARYSPAAVIKRMEDLGIGTKATRAQILETLYSRGYI-EGKKKi--KVTPLGMRVVEALERNVPDIVSVELTRAFEEKM 550
14601630  467 TPVRLDKASLLRWMESVNIGTEGTRARIIETLYKRGYLeGSRKS---EVTPLGEAVAVIIQTLFPELSKPDLTRRFESMI 543
126466161 523 PPEKINKIKILRWMENVGIGTEATRARIIEILFSRYYLrSVGGRv--EATDLGLGIIEVLMEYFPEITSVSLTRHFEEEM 600
156936802 458 PPERYTKAKIVKWMERVGIGTEATRARIVETLFKRGYLkNVGSKv--YATDLGIGVALVLSKFFPEIVSVELTRRFEEDM 535
218884347 482 PPKRLTKTDLLRWMESVEIGTEATRAQIIEKLFERKYLyQHQKSsgiDVSEIGFGVVEILEKFFPDLLSVELTRKFEKEM 561
14521628  473 PPARYSPAAVIKKMEDLGIGTKATRAQILETLYQRGYI-EGKKSi--KVTPLGMKVIETLEKYVPEIISVELTREFERKM 549
14590513  473 PPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYI-EGKKSi--KVTPLGMKVIETLEKYVPEIISVELTREFEKKM 549
305663582 474 PPHLPSKISLVKWMEEKGIGTEATRAEIVETLFKRGYLyMRGRGs--GVSELGILISFLLKDYVEELISVELTRKFEERL 551
302348228 479 PGLRLSRLSLLEWMEANDLGTKGTRARIIETLYKRGFItSRGSHa--EITNLGYAVYKVLSEVAPELMSVSLTRDFERML 556
296241915 491 PPQRISKIGMLRWMESVEIGTEATRATIIEKLFERKYLvNTSRGv--AVTDLGLGIVETLEIFFPELVKVELTRHFEKLM 568
212223461 551 EEIMAGKADKDRVIEESKEQLIKILQQF-K-EKELDIGKVLMETTGtgvttskenakragtvkelseteekdvkktiekg 628
14601630  544 EDIRSGRRTRQEVIDMSKKTISKLLESF-L-DRLDTAVREIGVSLG---------------------------------- 587
126466161 601 EKIRLGVKRREEVVKDAKNTLIKLIVSF-D-KKKYQIGKTLSYRLG---------------------------------- 644
156936802 536 KKIMMGVERKEKIVEEAKKFMRMILAKY-K-PHMREVGEYLAYSLG---------------------------------- 579
218884347 562 DSIRSGVKRRSEVLEEARRVLTELLGKF-D-RNRIEAGKQLALRLK---------------------------------- 605
14521628  550 DLIMQGKLTKEEVIEEAKVKLTKILEEF-K-KRELEIGLELARIVVgdvkd--------------------------eik 601
14590513  550 ELIMEGRLTKEEVIEEAKERLTKILEEF-K-KRELEIGIELAKIVVge-------------------------------d 596
305663582 552 NMILNMKAKCDDIVEEAKEMLLKYINRV-KsLDIQTLRAEISKYIE---------------------------------- 596
302348228 557 DEISMGKASREEVVSRAKKYISELVERQlNsNNIKVMGTYLAEFIG---------------------------------- 602
296241915 569 NDIKKGVVKREQVITEARNTLDMLIKKF-N-EKKETVGQILSSRLG---------------------------------- 612
212223461 629 eKTPLVvGKCPK--CGGDL--------VVRYNRKTGKRFVGCSNWPKCNVTYPLLQRGRIIPTNKT-CCDGAPVVKIrek 697
14601630  588 -SVEVE-AACHL--CGRKAvsavsgyrLCSHHMEAFDRLRKALPNLASTISSTPREALEAIARGRSrAGAWVRDVAA--- 660
126466161 645 -YITPI-NKCIL--CNREAyk----nnLCKYHYRALNTVIKTYDEWKRREGVDWNKYLSSIKKLKS-TGKWIVEVIQn-- 713
156936802 580 -EMEPP-GRCAV--CWRVAee----dgLCVVHKRARDELYAKYPVWRRRLGLSFEEYLKKVTTLKQ-AGTAAKEVAKa-- 648
218884347 606 -IIQNT-RKCRVssCYREGvv----ngLCSHHANAVKLVREYYGEWSRRKDITFNEYIDKLRKSKL-TGKWVKEVIEs-- 676
14521628  602 eEKPIVvGKCPK--CGGDL--------IVKYNKKTGKRFVGCSNWPKCDVTYPILQRGEIIPTNKT-CCNGAPVVIIrdk 670
14590513  597 eVKPLVvGKCPK--CGGDL--------IVKYNKKTGKRFVGCSNWPKCDVTYPILQRGEIIPTNKTcCNGAPVVIIReed 666
305663582 597 -MSDNNgRRCMI--CKRSVya----nnLCIFHNIALENIRSAYETWR-KFGFSWTQYLEKLLKLKS-TGSYVKEVCRh-- 665
302348228 603 -KVRPR-SRCAI--CGRPTdg----qsLCELHLAAKSNLEKSIDEVARRLGVSKEEALRRISNNRL-AGKWVRDVAAl-- 671
296241915 613 -IYTPP-NKCAI--CNREEfs----ngLCTYHYKANEQINKVYEEWKEREGVSFKEYLERIKKLKS-TGKWVIEVIEh-- 681
212223461 698 greyeicLDMNCKDWK 713
14601630  661 -------LALRDDGLY 669
126466161 714 ------fEKIKYSPSE 723
156936802 649 -----------lLSEP 653
218884347 677 ------eLT------- 679
14521628  671 grdieicLDIKCKKW- 685
14590513  667 grefeicLDINCKDWK 682
305663582 666 ------lIKQGEF--- 672
302348228 672 ------mISGKERP-- 679
296241915 682 ------fYGGK----- 686
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