Conserved Protein Domain Family
Cucumopine_C

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pfam18631: Cucumopine_C 
Cucumopine synthase C-terminal helical bundle domain
McbB from Marinactinospora thermotolerans is an enzyme that catalyzes the Pictet-Spengler (PS) reaction of L-tryptophan and oxaloacetaldehyde to produce the betaC scaffold of marinacarbolines. This is the C-terminal domain composed of 5 bundled alpha helices. It is weakly similar to the signal transduction histidine-protein kinase BarA from E. coli and the DNA endonuclease I-MsoI from Monomastix sp.
Statistics
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PSSM-Id: 408413
Aligned: 12 rows
Threshold Bit Score: 180.576
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KFY67908     134 VKELVQEIHNETEKSWSGISTDLKLVHRGLAKAspGSKDSYFATMVFINGEIRPLGYNVLNGTLKiAATQpGYSLEHLIG 213
BAJ33279     156 AQALLDDLHAHTERVWLAPPADLLALHRGDVPL--GSRGQYFSTLVYVNGELRLLGSTTLNPLVA-ATFDpDVTLDALRA 232
Q13WR5       155 LAPLAQKLYDEAERIQLVEPEEIRALRLGEVEDa-GTYGQYFSAWDFANGMLRDYIMYTIYPILTlAGK---LEPKALSQ 230 Paraburkholderi...
Q13WR6         8 LSEFTAEVEAMTAAMMTEEPQEIASMRCGEMENtaGSYGQYFGTWDIAHGMLRDYSMYTLYPITAlAEDA-EMDLTSLSK 86  Paraburkholderi...
EST53923       5 IEDFLTELEKEIEEIWVNEPEDIYALKKGYLPSgaGIYGQYYSVLVMLGGEMRALGIHIFADLIAfSQDP-EFDLKHLQT 83 
EGA95531       3 WKAAIDKFEERRLAIWENMPQDVYDLSGGKVPGdtNVYGQYVTTMMYADSELRTLCDEVLFYMIEtAKEG-DVDLRTLIH 81 
WP_025421173   3 IDEVIARFEQEREKIWFDQPDEVKALGQGIVPRgtGSRGQYLSTIIFAEGEARTMADEMLWGLIRvAEDT-DADLKTLQS 81  Sodalis praecap...
CAP79846     171 VKKLVREIHEEMDRSWSGMSENIKAIHTGRAPSypGSKDSYFAAMLFANSEVRTLGYYIFDNILKlAATCpEFELKHLVI 250
GAO88108     174 VRNLVEEIHKETEKSWSSVSAEIEKLHHGQAPAkpGSKNSYLGAMMFSNSVVRTLGYHIFDNILKiAATRpEFTLQHLII 253
XP_001395763 175 VRNLVEEIHTETQKCWSDISDDIEEIHYGNAPEkpGSKDSYFGPMLFSNSVVRTLGYHVIDNIIKlAFTRpEFTLGHLIA 254
WP_048832648 157 ARDLIERIAAETERVLIEPTDELIAAHEGRFDTgaGTKGSVLTTLVCINGETRPLGYVSHTGLVRaARLT-DVPLSALVE 235 Streptomyces va...
KUM92851     163 ASHLIADIVAETEKIWLAPPAELDDLHQGIIPSqaGNFGTVLPTLLFVNGETRPLGYAAYGGLVRaAVQD--MPMASLVH 240
KFY67908     214 IYRVFALTPSEFVGYTGANFLCSTHNKIEELIekvvernqNQVVAREDFLAMVSAFALYVNLLNAQNLHL 283
BAJ33279     233 LLPRLTAMQTDFLGHCGFHDLHALVHRTHRVL--------PALRTKEEFRSVTAALALYVNCLRRWALHH 294
Q13WR5       231 VLNELDVPYSSYLSVVGFKKLEALAGELREYV--------ATAETKEEIQQVLRAFLKYGNRLCAWSYQM 292 Paraburkholderia xenovora...
Q13WR6        87 TVDALDPAYSNYLRYSGFPRMGKLAVELRGLI--------RASTSRSDIVAALRAFTAYTNRLQAWSFHY 148 Paraburkholderia xenovora...
EST53923      84 MAKRMLKIDVGVISYFGLARYGRYLSRYHELI--------EDMESKEEFARVTKSMFTYTNRYQMWLHQI 145
EGA95531      82 FAKRILDYKAKFFVFTGVPMASELLFMYLEAL--------DSVETLEEFVHLSNAALKYFNRHHMW-VDL 142
WP_025421173  82 LIKEIIGYKADFFDFVSLPHAASLIHLYVDTA--------CRCTTLEELCRLSHAALSYANRLHMW-VDF 142 Sodalis praecaptivus
CAP79846     251 LYRELVSVPAEFLGYVGTDFLRNSHRQIDDLItfnvekndNQSEAREDLLAMVSVLAQYINLLNAQNLLL 320
GAO88108     254 LFRDLIPSISEFIGYLGVEFLCDSYWKADKLIkeniesnpDQEEAREDFLAIVSALGFYVNLLNAQNLHM 323
XP_001395763 255 LFRDFVPSIADFVGHLGAEYVNDIHERIDKLIkekveknpNKEEAREVFLAMISAFSFYVNLLNAQNLHM 324
WP_048832648 236 LAKILLVKPTEFLGYCGLNTLWDLTQEVVAAI--------GETSSKEDFIALLSHMATYTNALGAWNLQL 297 Streptomyces varsoviensis
KUM92851     241 MARLLVGVPAEFLGYCGLEKLWAFTQRFLGVL--------DRL-DRDDFYAVTSQMALYINCLGGWNLQL 301
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