Conserved Protein Domain Family
Thermopsin

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pfam05317: Thermopsin 
Thermopsin
This family consists of several thermopsin proteins from archaebacteria. Thermopsin is a thermostable acid protease which is capable of hydrolysing the following bonds: Leu-Val, Leu-Tyr, Phe-Phe, Phe-Tyr, and Tyr-Thr. The specificity of thermopsin is therefore similar to that of pepsin, that is, it prefers large hydrophobic residues at both sides of the scissile bond.
Statistics
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PSSM-Id: 368384
Aligned: 31 rows
Threshold Bit Score: 207.496
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EQB67680           114 TPGY-SISPa--PMGIGDYGLMNQSGkitTYNYTTQSFEAVLSMNQLNNFYLAAN----DAHS--VTFQLNAVLdnvglf 184 
jgi:Tpen_1285      123 YGL---------PAGLASYP---------DVAVNTSMVLGFFNVSAASAKSYSSR----AAEAdaWSLQLNAVVevs-la 179 
Q96X85             100 QLYYgSGRPa--PTGIADYGIELNGGtvkPYVEEFNGVIGVAQIYSISALNGT-------NYG--ASLQLNTVLqv--nt 166  Sulfuris...
RogerUC:Ahos_1786  117 NYYV-LTRPl--PTGIADYGLKVSNGtvsPYIEKIKSVIGAVEINKLLAYNSTPPsg-iGQYC--ASIQLNVVLqv--nt 188 
Q97WS1             116 NYYI-LTRPl--PTGIADYGLKINNGvisPYIEKIKSVIGAVEINKLLAYNSTPPag-vSQYS--ASIQLNVVLqv--nt 187  Saccharo...
CBRAS:FFONT_0178   149 YSYY-NSLPa--PIGIADYGVVNSSGvliPYELLYKEAIGIANIYSIEAYNSTSPsg-vSEYG--ASLQLNVVLqv--nt 220 
jgi:Msed_1018      140 FTVH-SYLPa--PVGIADYGVKNTSKglqGYIVKFNEVVGEFTVNSISAYNSTPPsg-iSPYS--ATLQLNVVLqv--nt 211 
jgi:Msed_1230       28 FLYY-TSPPa--PSGIASFGLYNNSGkvtPYVIETSKVLGYANITSLLAYYKQARkygvNPYS--ATLQMNVVLqv--nt 100 
P17118              46 YLYY-TSPPa--PAGIASFGLYNYSGnvtPYVITTNEMLGYVNITSLLAYNREALrygvDPYS--ATLQFNIVLsv--nt 118  Sulfolob...
jgi:Vdis_0623      142 tHNY-STPIinaPIGIVDYGLMPSQVgyiPYSYMTNEFLGEARVLSIGVQPLTNCpp-lPPGS--FSLQLNAVLem--vv 215 
EQB67680           185 GTASQ-MWTQNVV--------VYSSRTHN--LTFEDNVWNFSSPTASLTNNAInyssaqeQGHGFTG-------GGFHYG 246 
jgi:Tpen_1285      180 GGRKQyYWVQNMVggiegtrsYENKTEKAimYQVWNNIWNNTGRLSLLSDERI-------SGCGGVYrd----rDEYYYA 248 
Q96X85             167 AQGTQqYWLQNVI--------QFITNESI--YRYVDNVWNFTSSPSELNSSLI-------HGEGYVYttg-ilsPCSYYA 228  Sulfuris...
RogerUC:Ahos_1786  189 ISGTRqIWLQNVI--------QINTYNNS--YRFIDNIWNFTSYPSILCNCV--------KGNGGVYfmfqgirVCDYYA 250 
Q97WS1             188 IGGSQqLWLQNVI--------QIYTNNDS--YIFLDNIWNFTGKISILSNSTV-------KGNGIVYvt---nnGNDYYA 247  Saccharo...
CBRAS:FFONT_0178   221 TYGSYtYWVQNVP--------NFWTNNNT--LFFVDNVWNFTSHFSFLTNQSV-------KGNGYVYvd---nvGEDYYA 280 
jgi:Msed_1018      212 VHGGYqYWLQDVL--------LFFTNNDT--ACVEDNVWNFTSYPSILSNSTL-------TGQGHVYpyregnyIEYYYA 274 
jgi:Msed_1230      101 TQGTFaYWLQDVG--------SFQTNTNQ--VTFIDNIWNLTGNPSTLSSSAV-------SGNGKVAsag--sgNTFYYD 161 
P17118             119 SNGVYaYWLQDVG--------QFQTNKNS--LTFIDNVWNLTGSLSTLSSSAI-------TGNGQVAsag--ggQTFYYD 179  Sulfolob...
jgi:Vdis_0623      216 NNKTQyYWVQNVL--------IIDPTYGL--MAPLVNVWNMSSAELFMDPLFI-------VGRGSVMn------NEVYAY 272 
EQB67680           247 yskT-FNMTYPFTLDLYLNTSVTASGNsVVWYNYTIVsgyinqttgaskgKVSGNYDEVIFNSTYGQPssyraphpTYLV 325 
jgi:Tpen_1285      249 cvyTySPCDLPLAGFLVVRA-YASNGAvHVDFGYVTAqsgd------yrpAIITWYDNVTIRTNPPAVg------aGIVA 315 
Q96X85             229 yatQyFNMTYPFYAVLFISVQTIPQGV-LVHFGYLn-------------gSMTVWYDNVTINISGIESa-------YLLV 287  Sulfuris...
RogerUC:Ahos_1786  251 ystNyFTLFSPSIEYLIINTSYTSQGP-IILFGYMnq------------sGYPVWYDNVSILIPGTLSa-------YILI 310 
Q97WS1             248 ygtNfSTLLIPSLKYLLINTSYTSQGP-MISFGYMnq------------sGSPIWYDNVTILIPNTLSa-------YILV 307  Saccharo...
CBRAS:FFONT_0178   281 ystEmRKYTLPLNLKLAVSENFSSNAV-YISFGYSLGe-----------sEEITWYDKVIIPQTGITSa-------SFII 341 
jgi:Msed_1018      275 ygiSaFRYSTPFKGQLVMRTNVVPQGI-EVMFGFYN--------------GTMNWYDNVTIHESGVTSa-------YMLV 332 
jgi:Msed_1230      162 vgpT-FTYSFPFSYVYVVNTSYTSNSV-SIWFGYEILqgs--------qvTSVQYYDKVTISQPGIKSa-------EITI 224 
P17118             180 vgpS-YTYSFPLSYIYIINMSYTSNAV-YVWIGYEIIqigq------teyGTVNYYDKITIYQPNIISa-------SLMI 244  Sulfolob...
jgi:Vdis_0623      273 mgnW-TPYEMPLSVNLTIITNKTVNGFpQVLIGYSMG-------------GINTLVDNVTFLMTPSWGp-------HLVV 331 
EQB67680           326 SGTNLTPTGyIPYDAEIMIGGPGGGSTAFVNGINGTMNLMY--YNNTTsaYHNVRAAYDIGSETGETSVGV 394 
jgi:Tpen_1285      316 TSSYLNGRG-LPLNVELVFCGFCCSEHATFSELEARLTLAY--WRGGG--WAPFPNLYSFGVSTNETATNV 381 
Q96X85             288 DGYNVTGSG-NAYDTELVFGGISKGEITYYNSLSAMLYFVY--VNSTN--VITPKALLPFGLDTAEASDNL 353  Sulfurisphaera to...
RogerUC:Ahos_1786  311 DGYNLTGNN-HSYDAELILGGGGSGEFTFFNESNVELAMIYqyLNGT---LAPPKYLFPFGLDTEESADNL 377 
Q97WS1             308 DGYNFTAGG-LAYDAELILGGGGNGEFTFFNESNVELAMIYqyLNGT---LAPPKFLFPFGLDTEESADNL 374  Saccharolobus sol...
CBRAS:FFONT_0178   342 SGFSQTPSG-HFYDSELVFGGEGNREITNFTKMNAQLMLKYv-LENET--IVLPMSLYGFGSDTAEGADDL 408 
jgi:Msed_1018      333 DGFNTTGRG-VRYDAELVFGGGGSGEITNFNSMNSTLSLMYv-VNGVN---ETPQELYGYGADTAEAADNL 398 
jgi:Msed_1230      225 NGNTYTPDG-LYYDAELVWGGGGNGAPTQFTHLNSSLGLYY--LSSTG--VTPIPSLYTFGSNTGESAYNV 290 
P17118             245 NGNNYTPNG-LYYDAELVWGGGGNGAPTSFNSLNCTLGLYY--ISNGS--ITPVPSLYTFGADTAEAAYNV 310  Sulfolobus acidoc...
jgi:Vdis_0623      332 NGSEYSPLG-YLIDAEFVIGGPGCGAMVRVNELNATLSLYY---RGPSgdLIPMPSAWSMGSDTGETVVNA 398 
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