Conserved Protein Domain Family
MCR_C

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pfam04609: MCR_C 
Methyl-coenzyme M reductase operon protein C
Methyl coenzyme M reductase (MCR) catalyzes the final step in methanogenesis. MCR is composed of three subunits, alpha (pfam02249), beta (pfam02241) and gamma (pfam02240). Genes encoding the beta (mcrB) and gamma (mcrG) subunits are separated by two open reading frames coding for two proteins C and D. The function of proteins C and D (this family) is unknown. This family nowalso includes family MtrC_related,
Statistics
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PSSM-Id: 428033
Aligned: 30 rows
Threshold Bit Score: 377.716
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_004077478     3 FVPITYKGGVYKHDIILDLIDDLGGHIVQKHMIAQDVVLQCLVPKEDIPLIKETGRPFGSEVFESPLVGTEIAVISPSLE 82  Methanoplanus...
WP_016359099     2 YETLTYSGGIHKSNEMRELIEDLGGFIIQENVIQMDLVLNMAVPVDDVDKIKEKSKELLGKLTFAPMAGSEIAIVSPTLA 81  Methanobrevib...
agres:mru_1931   2 YETLTFTGGIHKSEELKELIEDLGGFVLQSNILQMELVLNMAVPIDDVKIIEDKANELLGELSVAPMAGSEIAIVSPTLA 81 
CDG65789         2 YETLTYTGGVHKHEEIKELIEDLGGFVLQETTSQMDLVLTLAVPVEDVDKVDEKSRELLGEIKRAPMAGTEIAIVSPTLA 81 
Q57559           6 YEIVRYEGGVYKNNIFKEWIEDIGGFVIQEHVMQLDVYMTLAIPQNELENIKEEAKKYKGKIIETPLAGTEIAVVAPSLS 85  Methanocaldoc...
jgi:Maeo_1204    2 YGIVRYEGGVYKNNIFKEWIEDIGGFIIQEHVMQLDVYMTLAIPQNEIENLKIESKKYKGKVVETPLAGTEIAIVAPSLS 81 
jgi:Mvol_1642    2 YQIVRYEGGVYKHNELKEWIEDVGGFIIQEHVMQLDVFMTVAFPEDEIGEFKALSKNYKGKVVETPLAGIEIAVVAPSLS 81 
Q6M050           2 YQIIRYEGGVYKNNILKEWIEDVGGFIIQEHVMQLDVYMTIAIPQNEIENFKEEAKKYKGKIVETPLAGIEIAIVSPSLS 81  Methanococcus...
Q8TXS7           7 FETVIYEGGVYKADEMRDLVEDLGGFVLSEHQMQLEVHMVLAVPVDDLDVIERKAEELLGEIRRMPLAGTEIAVVGMSLA 86  Methanopyrus ...
WP_015504306     2 YEVIMYDGGIYRSDELFELIEDVGGVVLLKNRSAQMLTVTMSIPSEDREVVEALCKDIGGQVKEVPLAGTEIAVVGPTLG 81  Candidatus Me...
WP_004077478    83 IHHLPHTSCDVAEYLRSAGAKTNMIGLARGFGKRIANLNIEERDIINEHDCAVLMLGNFESCIRHKLPALRRGIK-VPII 161 Methanoplanus...
WP_016359099    82 RHHLPHAACDISEYLRRFGAKDNMIGLARGHGKGTSGISQEEKYLIEEHDLAIFALGSFKDCIIE-KSFLFDDID-IPVI 159 Methanobrevib...
agres:mru_1931  82 RHHLPHAACDISEYLRRYGAKDNMIGLARGHGKGTAGISETEKALIEEHDIAIFALGSFKQCIVD-KAYLYNDID-IPVI 159
CDG65789        82 RQHLPHSACDISEYLRRYGAKDNMIGLSRGAGKGISRISEDEKRLIEEHDLVVFALGSFRECLMN-KTHLFNDID-IPVV 159
Q57559          86 RHHLPHTACDISEYLRRFGAKPNMIGLARGVGRDIAQLREKERRLIEEHDLAVYVMGNFEDCIKN-KTHLF-DVD-IPVV 162 Methanocaldoc...
jgi:Maeo_1204   82 RHHLPHTACDVSEYVRRFGAKPNMIGLSRGFGKKTSSIREAEKRLIEEHDIAIYVMGNFKSCLLD-KTHLF-DVD-IPVV 158
jgi:Mvol_1642   82 RHHLPHIACDVSEYVRKFGAKPNMIGLSHGAGKSISQIKEKEKRLIEEHDLAIYVMGNFKSCIED-KTHLF-EVD-IPVI 158
Q6M050          82 RHHLPHIACDVSEYVRKFGAKPNMIGLAHGAGKNISEIREKEKRLIQEHDIAIYVMGNFESCILD-KTHLF-KVD-IPLV 158 Methanococcus...
Q8TXS7          87 RHHMPHPVCDIAEYLRRHGAKSNVIGLARGYGRELAQLRTREKRLLEEHDLVIFVVGNFKDCIEKYKLPLVRRIErVPVV 166 Methanopyrus ...
WP_015504306    82 RHHMPHPICDVAEYLRRLGAVTVVMGLARGRGKNTSQINLQETSIIDEYDACVFMLGNFKPCVETKADLLLSKIN-IPTV 160 Candidatus Me...
WP_004077478   162 LTGGPdTESLSVLadPPLEGYVGNIGRIGHRMKKQEgEIEYLDDLVDVISGVLDEKREEIAKDPLSISPAKLMSTLDEEM 241 Methanoplanus...
WP_016359099   160 VTGAP-DIDIEEL--PGADAYVGGLGRIPRRLKRGE-NIRALRRLVQTTEDILNRKKKYMAEDAPLAPPVMVKNAIERQL 235 Methanobrevib...
agres:mru_1931 160 VTGAP-EIDLEEL--PGVDAYVPGLGRIPRRLKRGE-NIRALKHLVQTIEDLLEKRKKELAQDPPIVPSILVKNEIENQV 235
CDG65789       160 VTGAP-EMNLDDL--PGATAYVSGLGRIPRRLKRGE-NIRALRNLVEVVEDILDTRRKEMMDDPPIVPSILVKTEIENQV 235
Q57559         163 VTGGPeKIDIPY-------PYVGNLGRRSHRLRHGE-EIRALRKMVEVITELINERRRELSYDPPIVPPVVVKDEIEKQV 234 Methanocaldoc...
jgi:Maeo_1204  159 ITGAPeTLDIEQ-------PYIGNLGRRSQRLRHSE-ERQALKKMIEKTTELIDKRREELSFDAPIIPPVVLKDELEKSV 230
jgi:Mvol_1642  159 ITGGPqSIEVDK-------TYIGNLGRRSQRLRRGS-EIRALDSMIEKITEKIGEKRLELSYDPPIIPPVVLKDEIEKNI 230
Q6M050         159 VTGGPeTLDIPY-------TYVGNLGRRAQRLRKGE-EIRALRQMIDEVTKKINDKRMELSYDPPIIPPVVLKDEIEKRI 230 Methanococcus...
Q8TXS7         167 VVGGPeEIDADDV------VYVGGIGRKPYRFRKGR-EITKLDEIVDVVSKIIEERRQELAEDPPVVPPMVVKDRINREL 239 Methanopyrus ...
WP_015504306   161 LMCGPkPEGIEDT----CDAIVWGIGRKAARMREPE-DRKKLEEVGDRVDDVLDEKKKALEEDPPFVHPSEIKALLE-NF 234 Candidatus Me...
WP_004077478   242 QITKGSTHPTPITVQTAGLRVKIPYGEYADEVSAV 276 Methanoplanus limicola
WP_016359099   236 PEIKDVHTPTPITTQLDGLRVKLDYDKYHDKIGQV 270 Methanobrevibacter
agres:mru_1931 236 PAIEGVFSPTPVTSQLSGLRVKLDYDNYHEEIENV 270
CDG65789       236 KAVEEIYSPAPIVSQLDGVRVKLNYDEHKDEIAEV 270
Q57559         235 EEVYSILSPMPIVTQLDGLRVKLDYDKYADKIREV 269 Methanocaldococcus jannaschii DSM 2661
jgi:Maeo_1204  231 EEIFNVLSPMPITTQLDGLRIKLPYDACHEKIENV 265
jgi:Mvol_1642  231 ADVHGIFAPMPIVTQLDGLRIKLDYDRSHEKIENL 265
Q6M050         231 DEVRGILAPMPIVTQLDGLRIKMDYDRNHEEIENV 265 Methanococcus maripaludis
Q8TXS7         240 KIEERFTSPMPITLQLDGLRVKAPYDEWADRVAEV 274 Methanopyrus kandleri
WP_015504306   235 EPIDMCLRPAPLVMHLDGLRAKISYDEYHEQIENM 269 Candidatus Methanomethylophilus alvus
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