1MSV


Conserved Protein Domain Family
SAM_decarbox

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pfam01536: SAM_decarbox 
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Adenosylmethionine decarboxylase
This is a family of S-adenosylmethionine decarboxylase (SAMDC) proenzymes. In the biosynthesis of polyamines SAMDC produces decarboxylated S-adenosylmethionine, which serves as the aminopropyl moiety necessary for spermidine and spermine biosynthesis from putrescine. The Pfam alignment contains both the alpha and beta chains that are cleaved to form the active enzyme.
Statistics
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PSSM-Id: 426312
Aligned: 94 rows
Threshold Bit Score: 334.117
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1MSV_A         4 AHFFEGTEKLLEVWFSRQQPDA-Nqg-----sgDLRT-IPRSEWDILLKDVQCSIISVTKTDKQEAYVLSEASMFVSKRR 76  human
EFH59249       2 tTEFEGVEKRLEIVFRKEED-------------SLREvLTEEVWHDILRSIDCWIVDKLLTASVDSYLLSASSLFVFDDR 68  Arabidopsis lyr...
XP_009115932   4 DERFEGVEKRLEIVFSPTAG-------------KLREkLTQNLLEQILTDVKCHIVSHKLEEKVDAYLLSTSSCFVYDDR 70  field mustard
XP_004241063   3 ASGFEGFEKRLEIHFSGDDPAIeMg--------GLRQ-LDFDSLEQVLHAVQCTVVSAVSNQYFDSYVLSESSLFVYPTK 73  tomato
XP_002277316   3 vSGFEGFEKRLELHFSGDDPVVgM---------GLRH-LDFESLEQVLHAVQCTVVSAVGNHYFDAYVLSESSLFVYPTK 72  wine grape
EEF45432       3 vSGFEGFEKRLELHFFGDDPVMvDn-------mGLRL-LEFESLVNVLNAVQCTVVSAVGNQYFDAYVLSESSLFVYPTK 74  castor bean
XP_003542902   5 fsGFEGFEKRLELHFFGDDPTIlQl--------GLRK-LSFECIQQTLEAVQCTVVSAVGNSYFDAYVLSESSLFVYPTK 75  soybean
KRH02157       3 vSGFEGFEKRLELHFFGDDPAMfPl--------GLRK-LEFDSIEQVLEAVQCTVVSAVGNSYFDAYVLSESSLFVYPTK 73  soybean
Q8T1E3        26 SDGFEGPEKKLDIRFGPISKGSvKsiagspskvGLRT-IDKEKWQTVLDSARCTIISQTSNDHMDSYVLSESSLFVYPRR 104 Dictyostelium d...
Q587A7        25 ERSFEGPEKRLEVIMRVVDGTHvS---------GLLA-HDDDVWQKVIDAICAHIVSREFNEYIRSYVLSESSLFVMKDR 94  Trypanosoma brucei
1MSV_A        77 FILKTCGTTLLLKALVPLLKLARDYSGfDSIQSFFYSRKNFMKPSHQGYPHRNFQEE----IEFLNAIF--PN----GAA 146 human
EFH59249      69 LIIKTCGEIKLFQAITKILGLS----K-RTPVGVKFTRGTYFWPERQPEPHGNFPSE----VSELRRNF--LElddtVTA 137 Arabidopsis lyr...
XP_009115932  71 VIVKTCGETEIFKCMESLMGLTDH----QNVVSVVYTRGDFFWPERQPFPHNDVTEEnkefVKLLEKLTklKP----MKA 142 field mustard
XP_004241063  74 IIIKTCGTTQLLKSIRPFIHFA-CQMG-LIITECRYTRGNYIFPKAQPYPHTSFKEE----ISYLQDQL--PNhlcyRKA 145 tomato
XP_002277316  73 IIIKTCGTTQLLKSIPPLLHHG-RHLG-LAMCGCRYTRGSFIFPKAQPFPHTSFRDE----VIYLEQSL--PStlcyRKA 144 wine grape
EEF45432      75 IIIKTCGTTQLLKSIRPLLHYA-CNLG-LSLCSCRYTRGNFIFPKSQPFPHTSFKEE----VIYLEETL--PSnlcyRKA 146 castor bean
XP_003542902  76 IIIKTCGTTQLLKSITPLIFYAQTHLG-LTLSLCRYTRGSFIFPLSQPFPHTSFEHE----VTYLETTL--PSdlcfRKA 148 soybean
KRH02157      74 IIIKTCGTTQLLKSILPLIHYADHHLG-LTLSSCRYTRGSFIFPKAQPFPHTSFKDE----VTYLQDTI--PSslcfRKA 146 soybean
Q8T1E3       105 AMIKTCGTTTLLHLIAKMVQVG-KECG-LEVEMVVFSRKNLNQPSKQVFPHCSFSDE----VNFLNKIF---D----GQA 171 Dictyostelium d...
Q587A7        95 VILITCGTITLLNCVPLICEAVSTVCG--EVEWVSFMHKNYSFPWEQKGPHLSMAEE----FKTLRSHF--PS----GQP 162 Trypanosoma brucei
1MSV_A       147 YCMGRM-NSDCWYLYTLDFPES---------RVISQPDQTLEILMSELDPAVMDQFYMKD------GVTAKDVTRESGIR 210 human
EFH59249     138 EFGTD--EKHKFHIFAAaasg-----------ssvSDGVTVEILMTGIEKSKASVFFkds-------giPGSMTSASGID 197 Arabidopsis lyr...
XP_009115932 143 LCMGT--GNKKWHVLGGfsgds---------ltsqGDFVTVEMSMRGLDREKAKVFYeke------nvTKTTMTEESGIC 205 field mustard
XP_004241063 146 SVMPSkfTSHSWHVFSAcdkfy--------pipipNDQYTVEICMTDLDLVLARKFFknp------dtTGKQMTEVTGIG 211 tomato
XP_002277316 145 SVMPSkmSSHSWHVFSAsdephm------vlqhmpDVLYTLEVCMTDLDRVLARKFFlrpgagkagdvAGKEMTELTGIG 218 wine grape
EEF45432     147 SVMPSkmTSHSWHVFTAsdqnh--------fisqnHHLYTIEVCMTELDRVLARKFFqpagdgkngdvAGKEMTKLTGIG 218 castor bean
XP_003542902 149 SIMPSksSSHAWHVFTAtniphhh----sralyseRHAYTMEICMTDLDPVLARKFFrragdgktgdsAGKEMTEITGVD 224 soybean
KRH02157     147 SIMPSksSSHSWHVFTAndnthththspmpydhdnELLFTMEICMTELDPILARKFFrrpddeksgdsAGKEMTELTGIN 226 soybean
Q8T1E3       172 YVMGDV-NKDHWNLYIADFRKN---------PTLQRTEQTFEVMMHDLDETVMKQFFKRE------GVSAWDTTVNSGIA 235 Dictyostelium d...
Q587A7       163 FIFGPI-DSDHYFLYFHsdvv----------qpscSDDAQLSMTMYGLDRNQTKHWYsdkml--ptgpETAVIREATGLS 229 Trypanosoma brucei
1MSV_A       211 DLIP-GSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNL-SQ----TSYDDLIRKVVEVFKPGKFVTTL 284 human
EFH59249     198 QIFP-ESSICDHEFPTCGYSMNGVVGSNSVYTIHVTPEEGFSFASFEVCGcET----HSLEKLVQNVLSCFNPSTFTAVL 272 Arabidopsis lyr...
XP_009115932 206 YIFP-NAIIDAHAFDKCGYSMNGIEGK-GISTIHVSPEDEGSFASFESFGyDFkn-eKKFEHVIPTVLKCFSPKQFTMTV 282 field mustard
XP_004241063 212 EIIP-SALICEFAFDPCGYSMNGIDGD-RYSTIHVTPEDGFSYASYECVGsVYd--eDDIDRILKKVVQVFLPGTMSVSI 287 tomato
XP_002277316 219 DINP-GALICDFAFDPCGYSMNGIDGD-RYSTIHVTPEDGYSYASFECVGsIYdd-qNDVVQVLKKVVQVFRPATMSVST 295 wine grape
EEF45432     219 DINP-GAIICDFAFDPCGYSMNGIDSD-RYSTIHVTPEDGYSYASFECVGsIFddsdDDVAEVLKKVVQVFRPATMSVST 296 castor bean
XP_003542902 225 EINP-QALVCDFAFDPCGYSMNGIDGE-WYSTIHVTPEDGYSYASFECVGsVNd--dVDILHVLRKVVQIFRPGTMSVST 300 soybean
KRH02157     227 EINP-DALICDFAFDPCGYSMNGMDGD-WYSTIHVTPEDGFSYASFECVGsVDn---GNIGHVLMKVVQIFRPGTMSIST 301 soybean
Q8T1E3       236 DLLP-GSMIDDFQFDPCGYSMNGLLNE-FYWTIHITPESHCSYVSFDTNV-AL----ADYNQLLAKVLNVFKPGRFTAAL 308 Dictyostelium d...
Q587A7       230 EVVDdSWILHDLQYEPCGYSINAIRGS-EYQTIHITPEEHCSFASYETNT-CA----LNYSKCICGVLRVFDPERFSVIV 303 Trypanosoma brucei
1MSV_A       285 FVNQ---SS----KcrtvlaSPQKIE-------GFKRLDCQSAMFN-DYNFVFTSF 325 human
EFH59249     273 HTRS-------------------KLElldlnieGRICKEKDCKNLGsYGTMTYlsf 309 Arabidopsis lyrata subsp. lyrata
XP_009115932 283 YSTVp---------------LEGNEPelkvdlkGYKCLEEKIHKLDnGGSVVYQSF 323 field mustard
XP_004241063 288 SCSSsssSSeistRivka-----------veplGMKRRNCTIDEFPaAGTVVFQtf 332 tomato
XP_002277316 296 TCTS----HevwtRvata-----------lepmGLKCRSCAVDEFPaAGSMVFQTF 336 wine grape
EEF45432     297 TCNS----HevwtRvahs-----------ldplGMKCRSCTVDEFPaTGSVVFQTF 337 castor bean
XP_003542902 301 TSLG----SemwrEvsga-----------vepmGMKLRSCAMDQFPdSGSVVFQTF 341 soybean
KRH02157     302 TCNGfssNDvmwtEmasa-----------veplGFKCRSWAMDQFPnAGTVVFQTF 346 soybean
Q8T1E3       309 YAED---GApc-gDpyt--afdVNVP-------SYAIQNKTVHGFDgGYDVVVSNY 351 Dictyostelium discoideum
Q587A7       304 FIDP---DSavgk----syhSGGTIGvepeyypNYEAHHRTVNEYTpGHWVLKVNY 352 Trypanosoma brucei
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