4JCT,5VZ2,2F6I,4RYF,5E0S


Conserved Protein Domain Family
CLP_protease
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pfam00574: CLP_protease 
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Clp protease
The Clp protease has an active site catalytic triad. In E. coli Clp protease, ser-111, his-136 and asp-185 form the catalytic triad. Swiss:P48254 has lost all of these active site residues and is therefore inactive. Swiss:P42379 contains two large insertions, Swiss:P42380 contains one large insertion.
Links
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Statistics
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PSSM-Id: 425759
Aligned: 64 rows
Threshold Bit Score: 144.629
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4JCT_G  12 SRGE--RAYDIYSR-LLKDRIIMLGSAI-DDNVANSIVS-QLLFLDAQDPEKDIFLYINSPGGSISAGMAIYDTMNFVKA 86  Listeria monocytogene...
Q9CFR9   7 IKGD--VVDNSYGM-MYDWFGIDYTSPS-KVNDA----------L-VNADDEEIVLNIASNGGDVFAASEIYTAIKM-NG 70  Lactococcus lactis su...
Q8ZQG9  47 SGAE--SWYTIRAA-ADNAADISIYDEIgGWGISAHWFAeELVAL---GSITQINLHIHSPGGSIFDGLAIYNLLKNHPA 120 Salmonella enterica s...
P42380 310 SKALkaYNYLDQGA-LNNES----GRSL-YRKQTERVI--------QEEESKKVFMIINSFGGSVGNGITVHDALQFIKA 375 Chlamydomonas reinhar...
P38002   3 EGEMmhKLQDVIDRkLLDSRRIFFSEPV-TEKSATEAIK-KLWYLELTNPGQPIVFVINSPGGSVDAGFAVWDQIKMISS 80  Chlamydia trachomatis...
O51698   6 DNDAcvLHDKSLKL-VLKSRSIVIAGEI-TKDVSRLFQE-KILLLEALDFKKPIFVYIDSEGGDIDAGFAIFNMIRFVKP 82  Borreliella burgdorfe...
O84003  15 SGES--VFFQ---K-FLETRQILLSGEI-SKDLAEGIVR-QLFVLESLSVSKPIYMYVDSPGGDVDAGYAIFDVIRFVKT 86  Treponema pallidum su...
4RYF_D   4 ntknenitNILTQK-LIDTRTVLIYGEI-NQELAEDVSK-QLLLLESISND-PITIFINSQGGHVEAGDTIHDMIKFIKP 79  Listeria monocytogenes
Q8UD57  23 GKET--EAN------LFKSRSIFIYGGI-TQELAQKVCT-QLVAL-AAASDDDIRVYVNSPGGHVESGDSIHDMIKFIKP 91  Agrobacterium fabrum ...
Q9HYR9  13 SHGA--IGAKLMEY-ALKVRKVFVTGGV-DEKMAKDVVQ-QLHIL-ASISDDPIYMFVNSPGGHVESGDMIFDAIRFITP 86  Pseudomonas aeruginos...

4JCT_G  87 DVQTIGM-GMAASMGSFLLTAGANGKRFALPNAEIMIHQPLGGAQG--QATEIEIAARHILKIKERMNTIMAEKTGQPYE 163 Listeria monocytogene...
Q9CFR9  71 KPVTVNIqGLAASAASVIAMAGDTVN-IS-PTAQLMIHKAMSGSQG--NADDFEQEAKVLNGVDQSIAAAYELKTGMKQS 146 Lactococcus lactis su...
Q8ZQG9 121 RKVVYVD-GVACSMASVIAMVGDPV--IMPENAMMMIHRPRGIAGG--ESSDIRDYADLLDKMESVIIPIYAEKTGKSPD 195 Salmonella enterica s...
P42380 376 GSLTLAL-GVAASAASLALAGGTIGERYVTEGCHTMIHQPEGGLNG--QASDIWIDSQEIMKIRLDVAEIYSLSTYRPRH 452 Chlamydomonas reinhar...
P38002  81 PLTTVVT-GLAASMGSVLSLCAVPGRRFATPHARIMIHQPSIGGTItgQATDLDIHAREILKTKARIIDVYVEATGQSRE 159 Chlamydia trachomatis...
O51698  83 KVFTVGV-GLVASAAALIFLAAKLENRFSLPFARYLLHQPLSGFKG--VATDIEIYTNELNKVKKELNNIISKETGQKIS 159 Borreliella burgdorfe...
O84003  87 PVYTIGM-GLVASAGVLVLLAAKKDCRFGLRNSRYLIHQPLSGMRG--VATDIEIHARELEKTRSKLNALIASETGVSLD 163 Treponema pallidum su...
4RYF_D  80 TVKVVGT-GWVASAGITIYLAAEKENRFSLPNTRYMIHQPAGGVQG--QSTEIEIEAKEIIRMRERINRLIAEATGQSYE 156 Listeria monocytogenes
Q8UD57  92 KVYIIGT-GWVASAGALIYVSVPKERRLCLPNTRFLLHQPSGGTRG--MASDIEIQAREIIKMNQRLIKIFSKATGQTEE 168 Agrobacterium fabrum ...
Q9HYR9  87 KVIMIGS-GSVASAGALIYAAADKENRYSLPNTRFLLHQPSGGIQG--PASNIEIYRREIVRMKERLDRIFAEATGQTPE 163 Pseudomonas aeruginos...

4JCT_G 164 VIARDTDRDNFMTAQEAKDYGLIDDIIIN 192 Listeria monocytogenes EGD-e
Q9CFR9 147 DLLQLMSNETWMTAQDAVDKGFADNIMFV 175 Lactococcus lactis subsp. lactis
Q8ZQG9 196 DIAALLASETWMSGAECVREGFADKVIQP 224 Salmonella enterica subsp. enterica serovar Typhimurium
P42380 453 KILRDLDRDFYLTAMETIYYGLADEIATN 481 Chlamydomonas reinhardtii
P38002 160 VIEKAIDRDMWMSANEAMEFGLLDGILFS 188 Chlamydia trachomatis D/UW-3/CX
O51698 160 KIEKDTDRDFWLDSSAAKKYGLVFEVVET 188 Borreliella burgdorferi B31
O84003 164 KVAQDTNRDYWLDASQALEYGLISNLIEK 192 Treponema pallidum subsp. pallidum str. Nichols
4RYF_D 157 QISKDTDRNFWLSVNEAKDYGIVNEIIEN 185 Listeria monocytogenes
Q8UD57 169 KIAKDIDRDYWLSADDAKDYGLVGKIVES 197 Agrobacterium fabrum str. C58
Q9HYR9 164 KISADTERDFWLNAEEAVQYGLVNKIIVS 192 Pseudomonas aeruginosa PAO1
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