5O91,4UY9,3BI6,4AGU,5N4Z,6HHJ,3UZT


Conserved Protein Domain Family
Pkinase

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pfam00069: Pkinase 
Click on image for an interactive view with Cn3D
Protein kinase domain
Statistics
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PSSM-Id: 425449
Aligned: 38 rows
Threshold Bit Score: 228.262
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5O91_A        30 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTL------DSYRNEIAYLNKLQqhSDKIIRLYDYEIT--- 99   human
P32490       221 IETLGILGEGAGGSVSKCKLkNGSKIFALKVINTLNTDPEYQ------KQIFRELQFNRSFQ--SEYIVRYYGMFTDd-e 291  Saccharomyces ...
P06784       191 LVQLGKIGAGNSGTVVKALHvPDSKIVAKKTIPVEQNNSTII------NQLVRELSIVKNVKp-HENIITFYGAYYNqhi 263  Saccharomyces ...
P10506        66 LEVVRHLGEGNGGAVSLVK--HRNIFMARKTVYVGSDSKLQ-------KQILRELGVLHHCR--SPYIVGFYGAFQY--- 131  Schizosaccharo...
4UY9_A        11 LTLEEIIGIGGFGKVYRAF--WIGDEVAVKAARHDPDEDISQt----iENVRQEAKLFAMLK--HPNIIALRGVCLK--- 79   human
1_pfamImport   1 VMLSTRIGSGSFGTVYKGK---WHGDVAVKILKVVDPTPEQF------QAFRNEVAVLRKTR--HVNILLFMGYMT---- 65  
Q03497       620 YANLVKIGQGASGGVYTAYEiGTNVSVAIKQMNLEKQPKKEL--------IINEILVMKGSK--HPNIVNFIDSYVL--- 686  Saccharomyces ...
P27636        25 YHLKQVIGRGSYGVVYKAINkHTDQVVAIKEVVYENDEELND--------IMAEISLLKNLN--HNNIVKYHGFIRK--- 91   Saccharomyces ...
P28829       394 WIRGALIGSGSFGQVYLGMNaSSGELMAVKQVILDSVSESKDrhakllDALAGEIALLQELS--HEHIVQYLGSNLN--- 468  Schizosaccharo...
3BI6_A        11 FHELEKIGSGEFGSVFKCVKrLDGCIYAIKRSKKPLAGSVDE------QNALREVYAHAVLGq-HSHVVRYFSAWAE--- 80   human
5O91_A       100 DQYIYMVMEWGNID-----LNSWLKkk------ksIDPW-------ERKSYWKNMLEAVHTIH-QHG---IVHSDLKPAN 157  human
P32490       292 NSSIYIAMEYMGGRsldaiYKNLLErg------grISEK-------VLGKIAEAVLRGLSYLH-EKK---VIHRDIKPQN 354  Saccharomyces ...
P06784       264 NNEIIILMEYSDCGs----LDKILSvykrfvqrgtVSSKktwfnelTISKIAYGVLNGLDHLYrQYK---IIHRDIKPSN 336  Saccharomyces ...
P10506       132 KNNISLCMEYMDCGs----LDAILReg------gpIPLD-------ILGKIINSMVKGLIYLYnVLH---IIHRDLKPSN 191  Schizosaccharo...
4UY9_A        80 EPNLCLVMEFARGGp----LNRVLSgk-------rIPPD-------ILVNWAVQIARGMNYLH-DEAivpIIHRDLKSSN 140  human
1_pfamImport  66 KDNLAIVTQWCEGSs----LYKHLHvqe-----tkFQMF-------QLIDIARQTAQGMD-------------------- 109 
Q03497       687 KGDLWVIMEYMEGGs----LTDVVth-------ciLTEG-------QIGAVCRETLSGLEFLH-SKG---VLHRDIKSDN 744  Saccharomyces ...
P27636        92 SYELYILLEYCANGs----LRRLISrss-----tgLSEN-------ESKTYVTQTLLGLKYLH-GEG---VIHRDIKAAN 151  Saccharomyces ...
P28829       469 SDHLNIFLEYVPGGs----VAGLLTmy------gsFEET-------LVKNFIKQTLKGLEYLH-SRG---IVHRDIKGAN 527  Schizosaccharo...
3BI6_A        81 DDHMLIQNEYCNGGs----LADAISenyr--imsyFKEA-------ELKDLLLQVGRGLRYIH-SMS---LVHMDIKPSN 143  human
5O91_A       158 FLIV------------DGM--------LKLIDFGIANQMQPDTTsv----vKDSQVGTVNYMPPEAIkdmsssrengKSK 213  human
P32490       355 ILLNe-----------NGQ--------VKLCDFGVSGEAVNSL--------ATTFTGTSFYMAPERI----------QGQ 397  Saccharomyces ...
P06784       337 VLINs-----------KGQ--------IKLCDFGVSKKLINSI--------ADTFVGTSTYMSPERI----------QGN 379  Saccharomyces ...
P10506       192 VVVNs-----------RGE--------IKLCDFGVSGELVNSV--------AQTFVGTSTYMSPERI----------RGG 234  Schizosaccharo...
4UY9_A       141 ILILq-----------KVEngdlsnkiLKITDFGLAREWHRTT--------KMSAAGTYAWMAPEVI----------RAS 191  human
1_pfamImport 110 ----------------------------------------GSQQ-------VEQPTGSVLWMAPEVIrm-------qDNN 135 
Q03497       745 ILLSm-----------EGD--------IKLTDFGFCAQINELNLk------RTTMVGTPYWMAPEVV----------SRK 789  Saccharomyces ...
P27636       152 ILLS------------ADNt-------VKLADFGVSTIVNSS---------ALTLAGTLNWMAPEIL----------GNR 193  Saccharomyces ...
P28829       528 ILVDn-----------KGK--------IKISDFGISKKLELNSTstktggaRPSFQGSSFWMAPEVV----------KQT 578  Schizosaccharo...
3BI6_A       144 IFISrtsipnaaseegDEDdwasnkvmFKIGDLGHVTRISS----------PQVEEGDSRFLANEVL----------QEN 203  human
5O91_A       214 SKiSPKSDVWSLGCILYYMTYGKTPFQqiiNQIsklhAIID----------------------PnheiefpdIPEKDLQD 271  human
P32490       398 PY-SVTSDVWSLGLTILEVANGKFPCS----SEkmaaNIAPfellmwiltftpelkdepesniI---------WSPSFKS 463  Saccharomyces ...
P06784       380 VY-SIKGDVWSLGLMIIELVTGEFPLGghnDTPdgilDLLQrivneps---------prlpkdR--------IYSKEMTD 441  Saccharomyces ...
P10506       235 KY-TVKSDIWSLGISIIELATQELPWSf--------sNIDDsigildllhci----------vqeepprlpssFPEDLRL 295  Schizosaccharo...
4UY9_A       192 MF-SKGSDVWSYGVLLWELLTGEVPFRgidGLAvaygVAMNklalp-----------------------ipstcPEPFAK 247  human
1_pfamImport 136 PF-SFQSDVYSYGIVLYELMTGELPYShinNRDqiifMVGRgyaspdl-------------------sklykncPKAMKR 195 
Q03497       790 EY-GPKVDIWSLGIMIIEMIEGEPPYL------------NEtplralyliatn----------gtpklkepenlSSSLKK 846  Saccharomyces ...
P27636       194 GA-STLSDIWSLGATVVEMLTKNPPYHnltDANiyyaVENDtyyp-------------------------pssfSEPLKD 247  Saccharomyces ...
P28829       579 MH-TEKTDIWSLGCLVIEMLTSKHPYP----------NCDQmqaifrigen--------------ilpefpsniSSSAID 633  Schizosaccharo...
3BI6_A       204 YThLPKADIFALALTVVCA-AGAEPLP---RNGdqwhEIRQgrlpr-----------------------ipqvlSQEFTE 256  human
5O91_A       272 VLKCCLKRDPKQRISIPELLAHPYV 296  human
P32490       464 FIDYCLKKDSRERPSPRQMINHPWI 488  Saccharomyces cerevisiae S288C
P06784       442 FVNRCCIKNERERSSIHELLHHDLI 466  Saccharomyces cerevisiae S288C
P10506       296 FVDACLHKDPTLRASPQQLCAMPYF 320  Schizosaccharomyces pombe 972h-
4UY9_A       248 LMEDCWNPDPHSRPSFTNILDQ--L 270  human
1_pfamImport 196 LVADCVKKVKEERPLFPQILSSIEL 220 
Q03497       847 FLDWCLCVEPEDRASATELLHDEYI 871  Saccharomyces cerevisiae S288C
P27636       248 FLSKCFVKNMYKRPTADQLLKHVWI 272  Saccharomyces cerevisiae S288C
P28829       634 FLEKTFAIDCNLRPTASELLSHPFV 658  Schizosaccharomyces pombe 972h-
3BI6_A       257 LLKVMIHPDPERRPSAMALVKHSVL 281  human
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