Conserved Protein Domain Family
Pkinase

?
pfam00069: Pkinase 
Click on image for an interactive view with Cn3D
Protein kinase domain
Statistics
?
PSSM-Id: 306557
View PSSM: pfam00069
Aligned: 38 rows
Threshold Bit Score: 230.563
Threshold Setting Gi: 125256
Created: 11-Jul-2016
Updated: 4-Aug-2016
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3DTC_A          9 LTLEEIIGIGGFGKVYRAF--WIGDEVAVKAARHDPDEDISQti----enVRQEAKLFAMLK---HPNIIALRGVCLK-- 77
gi 341940540   25 YHLKQVIGRGSYGVVYKAInkHTDQVVAIKEVVYENDEELND--------IMAEISLLKNLN---HNNIVKYHGFIRK-- 91
gi 115195     394 WIRGALIGSGSFGQVYLGMnaSSGELMAVKQVILDSVSESKDrhaklldaLAGEIALLQELS---HEHIVQYLGSNLN-- 468
gi 417818     620 YANLVKIGQGASGGVYTAYeiGTNVSVAIKQMNLEKQPKKEL--------IINEILVMKGSK---HPNIVNFIDSYVL-- 686
gi 417302     221 IETLGILGEGAGGSVSKCKlkNGSKIFALKVINTLNTDPEYQk------qIFRELQFNRSFQ---SEYIVRYYGMFTDd- 290
gi 134968     191 LVQLGKIGAGNSGTVVKALhvPDSKIVAKKTIPVEQNNSTIIn------qLVRELSIVKNVKp--HENIITFYGAYYNqh 262
gi 115194      66 LEVVRHLGEGNGGAVSLVK--HRNIFMARKTVYVGSDSKLQk-------qILRELGVLHHCR---SPYIVGFYGAFQY-- 131
gi 1346396    534 RKFKVELGRGESGTVYKGVl-EDDRHVAVKKLENVRQGKe---------vFQAELSVIGRIN---HMNLVRIWGFCSE-- 598
3JXW_A         11 YQVGPLLGSGGFGSVYSGIrvSDNLPVAIKHVEKDRISDWGElpn--gtrVPMEVVLLKKVSs-gFSGVIRLLDWFER-- 85
gi 341941736 1096 FVSLQKMGEGAYGKVNLCIhkKNRYIVVIKMIFKERILVDTWvrdrklgtIPSEIQIMATLNkkpHENILRLLDFFED-- 1173
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3DTC_A         78 -EPNLCLVMEFARGGP----LNRVLSgk-------rIPPD-------ILV-NWAVQIARGMNYLH-DEAivpIIHRDLKS 136
gi 341940540   92 -SYELYILLEYCANGS----LRRLISrss-----tgLSEN-------ESK-TYVTQTLLGLKYLH-GEG---VIHRDIKA 149
gi 115195     469 -SDHLNIFLEYVPGGS----VAGLLTmy------gsFEET-------LVK-NFIKQTLKGLEYLH-SRG---IVHRDIKG 525
gi 417818     687 -KGDLWVIMEYMEGGS----LTDVVth-------ciLTEG-------QIG-AVCRETLSGLEFLH-SKG---VLHRDIKS 742
gi 417302     291 eNSSIYIAMEYMGGRSldaiYKNLLErg------grISEK-------VLG-KIAEAVLRGLSYLH-EKK---VIHRDIKP 352
gi 134968     263 iNNEIIILMEYSDCGS----LDKILSvykrfvqrgtVSSKktwfnelTIS-KIAYGVLNGLDHLYrQYK---IIHRDIKP 334
gi 115194     132 -KNNISLCMEYMDCGS----LDAILReg------gpIPLD-------ILG-KIINSMVKGLIYLYnVLH---IIHRDLKP 189
gi 1346396    599 -GSHRLLVSEYVENGS----LANIL-----------FSEGgnilldwEGRfNIALGVAKGLAYLH-HEClewVIHCDVKP 661
3JXW_A         86 -PDSFVLILERPEPVQd---LFDFITer------gaLQEE-------LAR-SFFWQVLEAVRHCH-NCG---VLHRDIKD 143
gi 341941736 1174 -DDYYY-IETPVHGETgcidLFDLIEfk------tnMTEF-------EAK-LIFKQVVAGIKHLH-DQG---IVHRDIKD 1233
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3DTC_A        137 SNILILq-KVEngdlsnkiLKITDFGLAREWHRTt--------KMSAAGAYAWMAPEVIRASMF-SKGSDVWSYGVLLWE 206
gi 341940540  150 ANILLS--ADNt-------VKLADFGVSTIVNSS---------ALTLAGTLNWMAPEILGNRGA-STLSDIWSLGATVVE 210
gi 115195     526 ANILVDn-KGK--------IKISDFGISKKLELNststktggaRPSFQGSSFWMAPEVVKQTMH-TEKTDIWSLGCLVIE 595
gi 417818     743 DNILLSm-EGD--------IKLTDFGFCAQINELnl------kRTTMVGTPYWMAPEVVSRKEY-GPKVDIWSLGIMIIE 806
gi 417302     353 QNILLNe-NGQ--------VKLCDFGVSGEAVNSl--------ATTFTGTSFYMAPERIQGQPY-SVTSDVWSLGLTILE 414
gi 134968     335 SNVLINs-KGQ--------IKLCDFGVSKKLINSi--------ADTFVGTSTYMSPERIQGNVY-SIKGDVWSLGLMIIE 396
gi 115194     190 SNVVVNs-RGE--------IKLCDFGVSGELVNSv--------AQTFVGTSTYMSPERIRGGKY-TVKSDIWSLGISIIE 251
gi 1346396    662 ENILLD--QAFe-------PKITDFGLVKLLNRGgst----qnVSHVRGTLGYIAPEWVSSLPI-TAKVDVYSYGVVLLE 727
3JXW_A        144 ENILIDlnRGE--------LKLIDFGSGALLKDTv--------YTDFDGTRVYSPPEWIRYHRYhGRSAAVWSLGILLYD 207
gi 341941736 1234 ENVIVDs-KGF--------VKIIDFGSAAYVKSGp--------FDVFVGTIDYAAPEVLGGNPYeGQPQDIWAIGILLYT 1296
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3DTC_A        207 LLTGEVPFRgidGLAvaygVAMNk-----------------------lALPIPSTC---PEPFAKLMEDCWNPDPHSRPS 260
gi 341940540  211 MLTKNPPYHnltDANiyyaVEND-------------------------TYYPPSSF---SEPLKDFLSKCFVKNMYKRPT 262
gi 115195     596 MLTSKHPYP----------NCDQmqaifr--------------igeniLPEFPSNI---SSSAIDFLEKTFAIDCNLRPT 648
gi 417818     807 MIEGEPPYL------------NEtplralyl----------iatngtpKLKEPENL---SSSLKKFLDWCLCVEPEDRAS 861
gi 417302     415 VANGKFPCS----SEkmaaNIAPfellmwi-----------ltftpelKDEPESNIi-wSPSFKSFIDYCLKKDSRERPS 478
gi 134968     397 LVTGEFPLGghnDTPdgilDLLQriv--------------------nePSPRLPKDriySKEMTDFVNRCCIKNERERSS 456
gi 115194     252 LATQELPWSf--------sNIDDsigildl-----------lhcivqeEPPRLPSSf--PEDLRLFVDACLHKDPTLRAS 310
gi 1346396    728 LLTGTRVSElvgGTDevhsMLRKlvrmlsaklegeeqswidgyldsklNRPVNYVQ---ARTLIKLAVSCLEEDRSKRPT 804
3JXW_A        208 MVCGDIPFEhdeEIIrgqvFFRQr----------------------------------vSSECQHLIRWCLALRPSDRPT 253
gi 341941736 1297 VVFKENPFY----------NIDEile-------------------gdlKFNNAEEV---SEDCIELIKSILNRCVPKRPT 1344
                         330
                  ....*....|
3DTC_A        261 FTNILDQ--L 268
gi 341940540  263 ADQLLKHvwI 272
gi 115195     649 ASELLSHpfV 658
gi 417818     862 ATELLHDeyI 871
gi 417302     479 PRQMINHpwI 488
gi 134968     457 IHELLHHdlI 466
gi 115194     311 PQQLCAMpyF 320
gi 1346396    805 MEHAVQtlls 814
3JXW_A        254 FEEIQNHpwM 263
gi 341941736 1345 IDDINNDkwL 1354
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap