2W4O,4NIF,4EJN,4AGU


Conserved Protein Domain Family
Pkinase

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pfam00069: Pkinase 
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Protein kinase domain
Statistics
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PSSM-Id: 333812
View PSSM: pfam00069
Aligned: 42 rows
Threshold Bit Score: 231.741
Threshold Setting Gi: 125256
Created: 13-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2W4O_A   55 FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKI----------VRTEIGVLLRLS---HPNIIKLKEIFET-- 119  human
P27636   25 YHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELn--------dIMAEISLLKNLN---HNNIVKYHGFIRK-- 91   Saccharomyces cerev...
P28829  394 WIRGALIGSGSFGQVYLGMNASSGELMAVKQVILDSVSESkdrhaklldaLAGEIALLQELS---HEHIVQYLGSNLN-- 468  Schizosaccharomyces...
Q03497  620 YANLVKIGQGASGGVYTAYEIGTNVSVAIKQMNLEKQPKKe--------lIINEILVMKGSK---HPNIVNFIDSYVL-- 686  Saccharomyces cerev...
P32490  221 IETLGILGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPEyq------kqIFRELQFNRSFQ---SEYIVRYYGMFTDd- 290  Saccharomyces cerev...
P06784  191 LVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPVEQNNSTii------nqLVRELSIVKNVKp--HENIITFYGAYYNqh 262  Saccharomyces cerev...
P10506   66 LEVVRHLGEGNGGAVSLVK--HRNIFMARKTVYVGSDSKLqk-------qILRELGVLHHCR---SPYIVGFYGAFQY-- 131  Schizosaccharomyces...
P80192  144 LTLEEIIGIGGFGKVYRAF--WIGDEVAVKAARHDPDEDIsqt----ienVRQEAKLFAMLK---HPNIIALRGVCLK-- 212  human
P17801  534 RKFKVELGRGESGTVYKGV-LEDDRHVAVKKLENVRQGKe---------vFQAELSVIGRIN---HMNLVRIWGFCSE-- 598  Zea mays
P31374 1096 FVSLQKMGEGAYGKVNLCIHKKNRYIVVIKMIFKERILVDtwvrdrklgtIPSEIQIMATLNkkpHENILRLLDFFED-- 1173 Saccharomyces cerev...
2W4O_A  120 -PTEISLVLELVTGGE----LFDRIVek------gyYSER-------DAA-DAVKQILEAVAYLH-ENG---IVHRDLKP 176  human
P27636   92 -SYELYILLEYCANGS----LRRLISrss-----tgLSEN-------ESK-TYVTQTLLGLKYLH-GEG---VIHRDIKA 149  Saccharomyces cerev...
P28829  469 -SDHLNIFLEYVPGGS----VAGLLTmy------gsFEET-------LVK-NFIKQTLKGLEYLH-SRG---IVHRDIKG 525  Schizosaccharomyces...
Q03497  687 -KGDLWVIMEYMEGGS----LTDVVth-------ciLTEG-------QIG-AVCRETLSGLEFLH-SKG---VLHRDIKS 742  Saccharomyces cerev...
P32490  291 eNSSIYIAMEYMGGRSldaiYKNLLErg------grISEK-------VLG-KIAEAVLRGLSYLH-EKK---VIHRDIKP 352  Saccharomyces cerev...
P06784  263 iNNEIIILMEYSDCGS----LDKILSvykrfvqrgtVSSKktwfnelTIS-KIAYGVLNGLDHLYrQYK---IIHRDIKP 334  Saccharomyces cerev...
P10506  132 -KNNISLCMEYMDCGS----LDAILReg------gpIPLD-------ILG-KIINSMVKGLIYLYnVLH---IIHRDLKP 189  Schizosaccharomyces...
P80192  213 -EPNLCLVMEFARGGP----LNRVLSgk-------rIPPD-------ILV-NWAVQIARGMNYLH-DEAivpIIHRDLKS 271  human
P17801  599 -GSHRLLVSEYVENGS----LANIL-----------FSEGgnilldwEGRfNIALGVAKGLAYLH-HEClewVIHCDVKP 661  Zea mays
P31374 1174 -DDYYY-IETPVHGETgcidLFDLIEfk------tnMTEF-------EAK-LIFKQVVAGIKHLH-DQG---IVHRDIKD 1233 Saccharomyces cerev...
2W4O_A  177 ENLLYAtpapDAP--------LKIADFGLSKIVEHQv-------lMKTVCGTPGYCAPEILRGCAY-GPEVDMWSVGIIT 240  human
P27636  150 ANILLS----ADNt-------VKLADFGVSTIVNSS---------ALTLAGTLNWMAPEILGNRGA-STLSDIWSLGATV 208  Saccharomyces cerev...
P28829  526 ANILVDn---KGK--------IKISDFGISKKLELNststktggaRPSFQGSSFWMAPEVVKQTMH-TEKTDIWSLGCLV 593  Schizosaccharomyces...
Q03497  743 DNILLSm---EGD--------IKLTDFGFCAQINELnl------kRTTMVGTPYWMAPEVVSRKEY-GPKVDIWSLGIMI 804  Saccharomyces cerev...
P32490  353 QNILLNe---NGQ--------VKLCDFGVSGEAVNSl--------ATTFTGTSFYMAPERIQGQPY-SVTSDVWSLGLTI 412  Saccharomyces cerev...
P06784  335 SNVLINs---KGQ--------IKLCDFGVSKKLINSi--------ADTFVGTSTYMSPERIQGNVY-SIKGDVWSLGLMI 394  Saccharomyces cerev...
P10506  190 SNVVVNs---RGE--------IKLCDFGVSGELVNSv--------AQTFVGTSTYMSPERIRGGKY-TVKSDIWSLGISI 249  Schizosaccharomyces...
P80192  272 SNILILq---KVEngdlsnkiLKITDFGLAREWHRTt--------KMSAAGTYAWMAPEVIRASMF-SKGSDVWSYGVLL 339  human
P17801  662 ENILLD----QAFe-------PKITDFGLVKLLNRGgst----qnVSHVRGTLGYIAPEWVSSLPI-TAKVDVYSYGVVL 725  Zea mays
P31374 1234 ENVIVDs---KGF--------VKIIDFGSAAYVKSGp--------FDVFVGTIDYAAPEVLGGNPYeGQPQDIWAIGILL 1294 Saccharomyces cerev...
2W4O_A  241 YILLCGFEPFYderGDQf---MFRRilnc-----------------eyyfISPWWDEV---SLNAKDLVRKLIVLDPKKR 297  human
P27636  209 VEMLTKNPPYHnltDANiyyaVEND-------------------------TYYPPSSF---SEPLKDFLSKCFVKNMYKR 260  Saccharomyces cerev...
P28829  594 IEMLTSKHPYP----------NCDQmqaifr--------------igeniLPEFPSNI---SSSAIDFLEKTFAIDCNLR 646  Schizosaccharomyces...
Q03497  805 IEMIEGEPPYL------------NEtplralyl----------iatngtpKLKEPENL---SSSLKKFLDWCLCVEPEDR 859  Saccharomyces cerev...
P32490  413 LEVANGKFPCS----SEkmaaNIAPfellmwi-----------ltftpelKDEPESNIi-wSPSFKSFIDYCLKKDSRER 476  Saccharomyces cerev...
P06784  395 IELVTGEFPLGghnDTPdgilDLLQriv--------------------nePSPRLPKDriySKEMTDFVNRCCIKNERER 454  Saccharomyces cerev...
P10506  250 IELATQELPWSf--------sNIDDsigildl-----------lhcivqeEPPRLPSSf--PEDLRLFVDACLHKDPTLR 308  Schizosaccharomyces...
P80192  340 WELLTGEVPFRgidGLAvaygVAMNk-----------------------lALPIPSTC---PEPFAKLMEDCWNPDPHSR 393  human
P17801  726 LELLTGTRVSElvgGTDevhsMLRKlvrmlsaklegeeqswidgyldsklNRPVNYVQ---ARTLIKLAVSCLEEDRSKR 802  Zea mays
P31374 1295 YTVVFKENPFY----------NIDEile-------------------gdlKFNNAEEV---SEDCIELIKSILNRCVPKR 1342 Saccharomyces cerev...
2W4O_A  298 LTTFQALQHPWV 309  human
P27636  261 PTADQLLKHVWI 272  Saccharomyces cerevisiae S288c
P28829  647 PTASELLSHPFV 658  Schizosaccharomyces pombe 972h-
Q03497  860 ASATELLHDEYI 871  Saccharomyces cerevisiae S288c
P32490  477 PSPRQMINHPWI 488  Saccharomyces cerevisiae S288c
P06784  455 SSIHELLHHDLI 466  Saccharomyces cerevisiae S288c
P10506  309 ASPQQLCAMPYF 320  Schizosaccharomyces pombe 972h-
P80192  394 PSFTNILDQ--L 403  human
P17801  803 PTMEHAVQtlls 814  Zea mays
P31374 1343 PTIDDINNDKWL 1354 Saccharomyces cerevisiae S288c
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