2W4O,4NIF,4EJN,4AGU


Conserved Protein Domain Family
Pkinase

?
pfam00069: Pkinase 
Click on image for an interactive view with Cn3D
Protein kinase domain
Statistics
?
PSSM-Id: 333812
View PSSM: pfam00069
Aligned: 42 rows
Threshold Bit Score: 231.741
Threshold Setting Gi: 125256
Created: 13-Mar-2017
Updated: 23-May-2017
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2W4O_A         55 FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKI----------VRTEIGVLLRLS---HPNIIKLKEIFET-- 119
gi 341940540   25 YHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELn--------dIMAEISLLKNLN---HNNIVKYHGFIRK-- 91
gi 115195     394 WIRGALIGSGSFGQVYLGMNASSGELMAVKQVILDSVSESkdrhaklldaLAGEIALLQELS---HEHIVQYLGSNLN-- 468
gi 417818     620 YANLVKIGQGASGGVYTAYEIGTNVSVAIKQMNLEKQPKKe--------lIINEILVMKGSK---HPNIVNFIDSYVL-- 686
gi 417302     221 IETLGILGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPEyq------kqIFRELQFNRSFQ---SEYIVRYYGMFTDd- 290
gi 134968     191 LVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPVEQNNSTii------nqLVRELSIVKNVKp--HENIITFYGAYYNqh 262
gi 115194      66 LEVVRHLGEGNGGAVSLVK--HRNIFMARKTVYVGSDSKLqk-------qILRELGVLHHCR---SPYIVGFYGAFQY-- 131
gi 116242625  144 LTLEEIIGIGGFGKVYRAF--WIGDEVAVKAARHDPDEDIsqt----ienVRQEAKLFAMLK---HPNIIALRGVCLK-- 212
gi 1346396    534 RKFKVELGRGESGTVYKGV-LEDDRHVAVKKLENVRQGKe---------vFQAELSVIGRIN---HMNLVRIWGFCSE-- 598
gi 341941736 1096 FVSLQKMGEGAYGKVNLCIHKKNRYIVVIKMIFKERILVDtwvrdrklgtIPSEIQIMATLNkkpHENILRLLDFFED-- 1173
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2W4O_A        120 -PTEISLVLELVTGGE----LFDRIVek------gyYSER-------DAA-DAVKQILEAVAYLH-ENG---IVHRDLKP 176
gi 341940540   92 -SYELYILLEYCANGS----LRRLISrss-----tgLSEN-------ESK-TYVTQTLLGLKYLH-GEG---VIHRDIKA 149
gi 115195     469 -SDHLNIFLEYVPGGS----VAGLLTmy------gsFEET-------LVK-NFIKQTLKGLEYLH-SRG---IVHRDIKG 525
gi 417818     687 -KGDLWVIMEYMEGGS----LTDVVth-------ciLTEG-------QIG-AVCRETLSGLEFLH-SKG---VLHRDIKS 742
gi 417302     291 eNSSIYIAMEYMGGRSldaiYKNLLErg------grISEK-------VLG-KIAEAVLRGLSYLH-EKK---VIHRDIKP 352
gi 134968     263 iNNEIIILMEYSDCGS----LDKILSvykrfvqrgtVSSKktwfnelTIS-KIAYGVLNGLDHLYrQYK---IIHRDIKP 334
gi 115194     132 -KNNISLCMEYMDCGS----LDAILReg------gpIPLD-------ILG-KIINSMVKGLIYLYnVLH---IIHRDLKP 189
gi 116242625  213 -EPNLCLVMEFARGGP----LNRVLSgk-------rIPPD-------ILV-NWAVQIARGMNYLH-DEAivpIIHRDLKS 271
gi 1346396    599 -GSHRLLVSEYVENGS----LANIL-----------FSEGgnilldwEGRfNIALGVAKGLAYLH-HEClewVIHCDVKP 661
gi 341941736 1174 -DDYYY-IETPVHGETgcidLFDLIEfk------tnMTEF-------EAK-LIFKQVVAGIKHLH-DQG---IVHRDIKD 1233
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2W4O_A        177 ENLLYAtpapDAP--------LKIADFGLSKIVEHQv-------lMKTVCGTPGYCAPEILRGCAY-GPEVDMWSVGIIT 240
gi 341940540  150 ANILLS----ADNt-------VKLADFGVSTIVNSS---------ALTLAGTLNWMAPEILGNRGA-STLSDIWSLGATV 208
gi 115195     526 ANILVDn---KGK--------IKISDFGISKKLELNststktggaRPSFQGSSFWMAPEVVKQTMH-TEKTDIWSLGCLV 593
gi 417818     743 DNILLSm---EGD--------IKLTDFGFCAQINELnl------kRTTMVGTPYWMAPEVVSRKEY-GPKVDIWSLGIMI 804
gi 417302     353 QNILLNe---NGQ--------VKLCDFGVSGEAVNSl--------ATTFTGTSFYMAPERIQGQPY-SVTSDVWSLGLTI 412
gi 134968     335 SNVLINs---KGQ--------IKLCDFGVSKKLINSi--------ADTFVGTSTYMSPERIQGNVY-SIKGDVWSLGLMI 394
gi 115194     190 SNVVVNs---RGE--------IKLCDFGVSGELVNSv--------AQTFVGTSTYMSPERIRGGKY-TVKSDIWSLGISI 249
gi 116242625  272 SNILILq---KVEngdlsnkiLKITDFGLAREWHRTt--------KMSAAGTYAWMAPEVIRASMF-SKGSDVWSYGVLL 339
gi 1346396    662 ENILLD----QAFe-------PKITDFGLVKLLNRGgst----qnVSHVRGTLGYIAPEWVSSLPI-TAKVDVYSYGVVL 725
gi 341941736 1234 ENVIVDs---KGF--------VKIIDFGSAAYVKSGp--------FDVFVGTIDYAAPEVLGGNPYeGQPQDIWAIGILL 1294
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2W4O_A        241 YILLCGFEPFYderGDQf---MFRRilnc-----------------eyyfISPWWDEV---SLNAKDLVRKLIVLDPKKR 297
gi 341940540  209 VEMLTKNPPYHnltDANiyyaVEND-------------------------TYYPPSSF---SEPLKDFLSKCFVKNMYKR 260
gi 115195     594 IEMLTSKHPYP----------NCDQmqaifr--------------igeniLPEFPSNI---SSSAIDFLEKTFAIDCNLR 646
gi 417818     805 IEMIEGEPPYL------------NEtplralyl----------iatngtpKLKEPENL---SSSLKKFLDWCLCVEPEDR 859
gi 417302     413 LEVANGKFPCS----SEkmaaNIAPfellmwi-----------ltftpelKDEPESNIi-wSPSFKSFIDYCLKKDSRER 476
gi 134968     395 IELVTGEFPLGghnDTPdgilDLLQriv--------------------nePSPRLPKDriySKEMTDFVNRCCIKNERER 454
gi 115194     250 IELATQELPWSf--------sNIDDsigildl-----------lhcivqeEPPRLPSSf--PEDLRLFVDACLHKDPTLR 308
gi 116242625  340 WELLTGEVPFRgidGLAvaygVAMNk-----------------------lALPIPSTC---PEPFAKLMEDCWNPDPHSR 393
gi 1346396    726 LELLTGTRVSElvgGTDevhsMLRKlvrmlsaklegeeqswidgyldsklNRPVNYVQ---ARTLIKLAVSCLEEDRSKR 802
gi 341941736 1295 YTVVFKENPFY----------NIDEile-------------------gdlKFNNAEEV---SEDCIELIKSILNRCVPKR 1342
                         330
                  ....*....|..
2W4O_A        298 LTTFQALQHPWV 309
gi 341940540  261 PTADQLLKHVWI 272
gi 115195     647 PTASELLSHPFV 658
gi 417818     860 ASATELLHDEYI 871
gi 417302     477 PSPRQMINHPWI 488
gi 134968     455 SSIHELLHHDLI 466
gi 115194     309 ASPQQLCAMPYF 320
gi 116242625  394 PSFTNILDQ--L 403
gi 1346396    803 PTMEHAVQtlls 814
gi 341941736 1343 PTIDDINNDKWL 1354
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap