4BDX,1IVO,6Y3C,5IKT


Conserved Protein Domain Family
EGF
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pfam00008: EGF 
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EGF-like domain
There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.
Links
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Statistics
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PSSM-Id: 394967
Aligned: 67 rows
Threshold Bit Score: 25.4211
Created: 28-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4BDX_A   48 CRTNP--CLHGgrCLEVE-----GHRLCHCPVG----YTGPF 78   human
P06579  143 CFDNN--CEYQ--CQPVGr----SEHKCICAEG----FAPVP 172  cattle
P07996  650 CTDGThdCNKNakC-NYLghysdPMYRCECKPG----YAGNG 686  human
P14543  672 CYIGThgCDTNaaCRPGPr----TQFTCECSIG----FRGDG 705  human
P01133  318 CKLRKgnCSSTv-CGQDL-----QSHLCMCAEGyalsRDRKY 353  human
P01133  401 CPRNVseCSHD--CVLTS-----EGPLCFCPEGsvleRDGKT 435  human
Q91VN0  298 CEEDNggCSHL--CLLSPr---ePFYSCACPTGvqlqDNGKT 334  house mouse
Q91VN0  604 CADGNggCSHL--CFFTP-----RATKCGCPIGlellSDMKT 638  house mouse
P01130  318 CLDNNggCSHV--CNDLK-----IGYECLCPDGfq-lVAQRR 351  human
P15216  256 CSQGTndCNENgeCVEED-----GKYWCECGEG----YEENE 288  purple sea urchin
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