1HZ8


Conserved Protein Domain Family
EGF

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pfam00008: EGF 
Click on image for an interactive view with Cn3D
EGF-like domain
There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.
Statistics
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PSSM-Id: 333761
View PSSM: pfam00008
Aligned: 67 rows
Threshold Bit Score: 26.9661
Threshold Setting Gi: 123880460
Created: 13-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
1HZ8_A          5 CLD--NNggCSHV--CNDLK-----IGYECLCPDGfq-lVAQRR 38
gi 115063     209 CKTkeAGfvCKHG--CRSTG-----KAYECTCPSGstvaEDGIT 245
gi 290457687 1625 CGIl-NG--CE-NgrCVRVQ-----EGYTCDCFDG----YHLDT 1655
gi 136169     143 CFD--NN--CEYQ--CQPVGr----SEHKCICAEG----FAPVP 172
gi 117949802  650 CTD--GThdCNKNakC-NYLghysdPMYRCECKPG----YAGNG 686
gi 251757450  672 CYI--GThgCDTNaaCRPGPr----TQFTCECSIG----FRGDG 705
gi 251757262  401 CPR--NVseCSHD--CVLTS-----EGPLCFCPEGsvleRDGKT 435
gi 341941014  298 CEE--DNggCSHL--CLLSPr---ePFYSCACPTGvqlqDNGKT 334
gi 341941014  604 CAD--GNggCSHL--CFFTP-----RATKCGCPIGlellSDMKT 638
gi 119221     256 CSQ--GTndCNENgeCVEED-----GKYWCECGEG----YEENE 288
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