U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CDC27 anaphase promoting complex subunit CDC27 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852194, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
CDC27
Official Full Name
anaphase promoting complex subunit CDC27
Primary source
SGD:S000000180
Locus tag
YBL084C
See related
AllianceGenome:SGD:S000000180; FungiDB:YBL084C; VEuPathDB:YBL084C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
APC3; SNB1
Summary
Contributes to ubiquitin protein ligase activity. Involved in anaphase-promoting complex-dependent catabolic process and protein ubiquitination. Located in nuclear periphery. Part of anaphase-promoting complex. Orthologous to human CDC27 (cell division cycle 27). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (67169..69445, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Boi1p Neighboring gene dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Molecular structure of the N-terminal domain of the APC/C subunit Cdc27 reveals a homo-dimeric tetratricopeptide repeat architecture. Zhang Z, et al. J Mol Biol, 2010 Apr 16. PMID 20206185
  2. The yeast CDC16 and CDC27 genes restrict DNA replication to once per cell cycle. Heichman KA, et al. Cell, 1996 Apr 5. PMID 8620535
  3. Mutually dependent degradation of Ama1p and Cdc20p terminates APC/C ubiquitin ligase activity at the completion of meiotic development in yeast. Tan GS, et al. Cell Div, 2013 Jul 1. PMID 23816140, Free PMC Article
  4. Cdc16p, Cdc23p and Cdc27p form a complex essential for mitosis. Lamb JR, et al. EMBO J, 1994 Sep 15. PMID 7925276, Free PMC Article
  5. Coactivator functions in a stoichiometric complex with anaphase-promoting complex/cyclosome to mediate substrate recognition. Passmore LA, et al. EMBO Rep, 2005 Sep. PMID 16113654, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaphase-promoting complex-dependent catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anaphase-promoting complex-dependent catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in metaphase/anaphase transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of anaphase-promoting complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
anaphase promoting complex subunit CDC27
NP_009469.2
  • Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    67169..69445 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178324.2 → NP_009469.2  TPA: anaphase promoting complex subunit CDC27 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009469.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPS0, P38042
    UniProtKB/TrEMBL
    G2W8S9, N1P6P8
    Conserved Domains (3) summary
    TIGR02917
    Location:500 → 741
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:540 → 568
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:39 → 126
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38042.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.