NF2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: NF2provided by VGNC
Official Full Name: NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressorprovided by VGNC
Primary source: VGNC:VGNC:75324
See related: Ensembl:ENSMMUG00000010311
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	10	NC_041763.1 (21851049..21952119, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	10	NC_027902.1 (71421621..71525611)

Chromosome 10 - NC_041763.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

D22S929 (e-PCR)
- UniSTS:150281

STS-L11353 (e-PCR)
- UniSTS:63028

GDB:361670 (e-PCR)
- UniSTS:156744

GDB:361675 (e-PCR)
- UniSTS:156745

GDB:361678 (e-PCR)
- UniSTS:156746

GDB:361681 (e-PCR)
- UniSTS:156747

GDB:361684 (e-PCR)
- UniSTS:156748

GDB:361687 (e-PCR)
- UniSTS:156749

RH27831 (e-PCR)
- UniSTS:85656

SHGC-30811 (e-PCR)
- UniSTS:25292

GDB:342145 (e-PCR)
- UniSTS:156635

GDB:373334 (e-PCR)
- UniSTS:156899

GDB:373359 (e-PCR)
- UniSTS:156900

GDB:373365 (e-PCR)
- UniSTS:156901

GDB:373372 (e-PCR)
- UniSTS:156902

GDB:373379 (e-PCR)
- UniSTS:156903

GDB:373387 (e-PCR)
- UniSTS:156904

GDB:373398 (e-PCR)
- UniSTS:156905

GDB:373405 (e-PCR)
- UniSTS:156906

GDB:373416 (e-PCR)
- UniSTS:156907

GDB:373421 (e-PCR)
- UniSTS:156908

GDB:373633 (e-PCR)
- UniSTS:156912

GDB:373637 (e-PCR)
- UniSTS:156913

GDB:373641 (e-PCR)
- UniSTS:156914

GDB:373645 (e-PCR)
- UniSTS:156915

GDB:373650 (e-PCR)
- UniSTS:156916

GDB:373653 (e-PCR)
- UniSTS:156917

GDB:373656 (e-PCR)
- UniSTS:156918

GDB:373660 (e-PCR)
- UniSTS:156919

GDB:373663 (e-PCR)
- UniSTS:156920

GDB:373677 (e-PCR)
- UniSTS:156922

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables cell adhesion molecule binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of early endosome to late endosome transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of protein localization to early endosome	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of gliogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of organelle assembly	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info	PubMed
located_in apical part of cell	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info	PubMed
located_in filopodium	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: merlin

Names: neurofibromin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001266255.1 → NP_001253184.1 merlin

See identical proteins and their annotated locations for NP_001253184.1

Status: PROVISIONAL

Source sequence(s)

JV564983

UniProtKB/TrEMBL

F6RPW5, H9EPK9

Related

ENSMMUP00000013508.4, ENSMMUT00000014420.4

Conserved Domains (6) summary

smart00295
Location:23 → 222

B41; Band 4.1 homologues

cd13194
Location:216 → 312

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00373
Location:107 → 222

FERM_M; FERM central domain

pfam00769
Location:347 → 595

ERM; Ezrin/radixin/moesin family

pfam09379
Location:26 → 87

FERM_N; FERM N-terminal domain

cl02098
Location:334 → 487

14-3-3; 14-3-3 domain

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041763.1 Reference Mmul_10 Primary Assembly

Range

21851049..21952119 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015150000.2 → XP_015005486.1 merlin isoform X1

UniProtKB/TrEMBL

F6RI41, F6RPZ9, H9EPL0

Related

ENSMMUP00000013505.4, ENSMMUT00000014417.4

Conserved Domains (4) summary

PLN03086
Location:307 → 367

PLN03086; PRLI-interacting factor K; Provisional

smart00295
Location:23 → 222

B41; Band 4.1 homologues

cd13194
Location:216 → 312

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00769
Location:347 → 579

ERM; Ezrin/radixin/moesin family
XM_015150001.2 → XP_015005487.1 merlin isoform X1

UniProtKB/TrEMBL

F6RI41, F6RPZ9, H9EPL0

Conserved Domains (4) summary

PLN03086
Location:307 → 367

PLN03086; PRLI-interacting factor K; Provisional

smart00295
Location:23 → 222

B41; Band 4.1 homologues

cd13194
Location:216 → 312

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00769
Location:347 → 579

ERM; Ezrin/radixin/moesin family
XM_028827379.1 → XP_028683212.1 merlin isoform X3

UniProtKB/TrEMBL

H9EPL0

Conserved Domains (4) summary

PLN03086
Location:307 → 367

PLN03086; PRLI-interacting factor K; Provisional

smart00295
Location:23 → 222

B41; Band 4.1 homologues

cd13194
Location:216 → 312

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00769
Location:347 → 479

ERM; Ezrin/radixin/moesin family
XM_028827378.1 → XP_028683211.1 merlin isoform X2

UniProtKB/TrEMBL

F6RPV5, H9EPL0

Related

ENSMMUP00000013509.4, ENSMMUT00000014421.4

Conserved Domains (4) summary

PLN03086
Location:307 → 367

PLN03086; PRLI-interacting factor K; Provisional

smart00295
Location:23 → 222

B41; Band 4.1 homologues

cd13194
Location:216 → 312

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00769
Location:347 → 524

ERM; Ezrin/radixin/moesin family