SPINK5 serine peptidase inhibitor Kazal type 5 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: SPINK5provided by VGNC
Official Full Name: serine peptidase inhibitor Kazal type 5provided by VGNC
Primary source: VGNC:VGNC:46745
See related: Ensembl:ENSCAFG00845025212
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	2	NC_051806.1 (42745184..42825339)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	2	NC_006584.4 (39331980..39411492)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	2	NC_049223.1 (41448356..41528467)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	2	NC_049262.1 (39815140..39895271)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	2	NC_049743.1 (40625209..40705273)

Chromosome 2 - NC_051806.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: serine protease inhibitor Kazal-type 5

Names: serine protease inhibitor, Kazal type 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025397.1 → NP_001020568.1 serine protease inhibitor Kazal-type 5 precursor

See identical proteins and their annotated locations for NP_001020568.1

Status: PROVISIONAL

Source sequence(s)

AJ972676

UniProtKB/TrEMBL

A0A8C0MBM2, A0A8C0QIZ4, A0A8P0SBZ6, Q4VYB4

Related

ENSCAFP00845034869.1, ENSCAFT00845044501.1

Conserved Domains (4) summary

smart00280
Location:793 → 831

KAZAL; Kazal type serine protease inhibitors

cd01327
Location:1003 → 1046

KAZAL_PSTI; Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the ...

pfam07648
Location:511 → 545

Kazal_2; Kazal-type serine protease inhibitor domain

cl00097
Location:929 → 958

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051806.1 Reference ROS_Cfam_1.0

Range

42745184..42825339

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038657803.1 → XP_038513731.1 serine protease inhibitor Kazal-type 5 isoform X1

UniProtKB/TrEMBL

A0A8C0MBM2, A0A8C0QIZ4, A0A8P0SBZ6

Conserved Domains (3) summary

smart00280
Location:662 → 700

KAZAL; Kazal type serine protease inhibitors

cd01327
Location:872 → 915

KAZAL_PSTI; Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the ...

cl00097
Location:311 → 336

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...