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HFE homeostatic iron regulator [ Pan troglodytes (chimpanzee) ]

Gene ID: 462489, updated on 3-Apr-2024

Summary

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Official Symbol
HFEprovided by VGNC
Official Full Name
homeostatic iron regulatorprovided by VGNC
Primary source
VGNC:VGNC:2860
Locus tag
CK820_G0045387
See related
Ensembl:ENSPTRG00000017805
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 5 NC_072403.2 (32056094..32065590)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 6 NC_072404.1 (32056022..32065598)

Chromosome 5 - NC_072403.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134810327 Neighboring gene H2B clustered histone 3 Neighboring gene H1.2 linker histone, cluster member Neighboring gene uncharacterized LOC112209452 Neighboring gene H1.6 linker histone, cluster member Neighboring gene H2B clustered histone 4 Neighboring gene H2A clustered histone 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence variation and haplotype structure at the human HFE locus. Toomajian C, et al. Genetics, 2002 Aug. PMID 12196404, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables peptide antigen binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transferrin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of T cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of iron ion transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to iron ion starvation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hereditary hemochromatosis protein homolog
Names
hemochromatosis
hemochromatosis protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009101.1 → NP_001009101.1  hereditary hemochromatosis protein homolog precursor

    See identical proteins and their annotated locations for NP_001009101.1

    Status: PROVISIONAL

    Source sequence(s)
    AF447807
    UniProtKB/Swiss-Prot
    P60018
    UniProtKB/TrEMBL
    A0A2I3SQG8, A0A2J8JQD9, A0A6D2VY27, K7D3A6
    Related
    ENSPTRP00000079201.1, ENSPTRT00000077752.1
    Conserved Domains (2) summary
    cd07698
    Location:206 → 298
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:27 → 202
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072403.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    32056094..32065590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016954624.4 → XP_016810113.2  hereditary hemochromatosis protein homolog isoform X1

    UniProtKB/TrEMBL
    K6Z9A0

  2. XM_016954625.3 → XP_016810114.2  hereditary hemochromatosis protein homolog isoform X2

    UniProtKB/TrEMBL
    K7AMN9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60018.1 GenPept UniProtKB/Swiss-Prot:P60018

Gene LinkOut

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