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Treh Trehalase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45368, updated on 11-Apr-2024

Summary

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Official Symbol
Trehprovided by FlyBase
Official Full Name
Trehalaseprovided by FlyBase
Primary source
FLYBASE:FBgn0003748
Locus tag
Dmel_CG9364
See related
AllianceGenome:FB:FBgn0003748
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
87D3T; anon-EST:Posey159; anon-sts38; CG9364; Dmel\CG9364; DmTre; ESTS:87D3T; FBgn0003748; Tre; TRE; treh; TREH
Summary
Enables alpha,alpha-trehalase activity. Involved in neuronal stem cell population maintenance and trehalose catabolic process. Located in cytoplasm. Is expressed in several structures, including circulatory system; embryonic/larval central nervous system; embryonic/larval muscle system; larval retrocerebral complex; and presumptive embryonic/larval system. Orthologous to human TREH (trehalase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
57B16-57B19; 2-92 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21074018..21088945)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16961523..16976450)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44703 Neighboring gene antisense RNA:CR44704 Neighboring gene Chitinase 9 Neighboring gene uncharacterized protein Neighboring gene Rabaptin-5 Neighboring gene uncharacterized protein Neighboring gene Gar1 ribonucleoprotein Neighboring gene king tubby Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Stress-related hormones affect carbohydrate metabolism in Drosophila females. Karpova EK, et al. Arch Insect Biochem Physiol, 2019 May. PMID 30793357
  2. Molecular cloning and in silico studies of physiologically significant trehalase from Drosophila melanogaster. Shukla E, et al. Int J Biol Macromol, 2016 Nov. PMID 27377458
  3. Trehalase regulates neuroepithelial stem cell maintenance and differentiation in the Drosophila optic lobe. Chen X, et al. PLoS One, 2014. PMID 25003205, Free PMC Article
  4. Genetic and biochemical aspects of trehalase from Drosophila melanogaster. Oliver MJ, et al. Biochem Genet, 1978 Oct. PMID 105719
  5. Adaptation to dietary conditions by trehalose metabolism in Drosophila. Yasugi T, et al. Sci Rep, 2017 May 9. PMID 28487555, Free PMC Article

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. both Tps1 and Treh mutant larvae exhibit a high lethality after desiccation stress. These results demonstrate that the regulation of trehalose metabolism is essential for normal development, body water homeostasis, and desiccation tolerance in Drosophila.
    Title: Molecular characterization of Tps1 and Treh genes in Drosophila and their role in body water homeostasis.
  2. The present study holds significance in understanding the structural aspects of Drosophila trehalase in spite of unavailabilty of eukaryotic trehalase crystal structure.
    Title: Molecular cloning and in silico studies of physiologically significant trehalase from Drosophila melanogaster.
  3. Treh plays a role in neuroepithelial stem cell maintenance and differentiation during Drosophila optic lobe development.
    Title: Trehalase regulates neuroepithelial stem cell maintenance and differentiation in the Drosophila optic lobe.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alpha,alpha-trehalase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha,alpha-trehalase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha,alpha-trehalase activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha,alpha-trehalase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in neuronal stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in trehalose catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in trehalose catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in trehalose catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in trehalose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in trehalose metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
trehalase
Names
CG9364-PA
CG9364-PB
CG9364-PC
CG9364-PD
CG9364-PE
CG9364-PF
CG9364-PG
Treh-PA
Treh-PB
Treh-PC
Treh-PD
Treh-PE
Treh-PF
Treh-PG
NP_001261115.1
NP_524821.1
NP_726023.1
NP_726024.1
NP_726025.1
NP_726026.1
NP_726027.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21074018..21088945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166422.2 → NP_726024.1  trehalase, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726024.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4UZR3, A5XCQ4
    Related
    FBpp0071464
    Conserved Domains (1) summary
    pfam01204
    Location:35 → 541
    Trehalase; Trehalase

  2. NM_001274186.1 → NP_001261115.1  trehalase, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261115.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4UZR3, A5XCQ4
    Conserved Domains (1) summary
    pfam01204
    Location:35 → 541
    Trehalase; Trehalase

  3. NM_080082.3 → NP_524821.1  trehalase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524821.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4UZR3, A5XCQ4
    Related
    FBpp0071465
    Conserved Domains (1) summary
    pfam01204
    Location:35 → 541
    Trehalase; Trehalase

  4. NM_166421.2 → NP_726023.1  trehalase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726023.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4UZR3, A5XCQ4
    Related
    FBpp0071466
    Conserved Domains (1) summary
    pfam01204
    Location:35 → 541
    Trehalase; Trehalase

  5. NM_166423.3 → NP_726025.1  trehalase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726025.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0E903, Q0E904, Q7YWL2, Q961P0, Q9W2M1, Q9W2M2, Q9W2M3
    UniProtKB/TrEMBL
    A5XCQ1, A5XCQ4, A5XCQ9
    Related
    FBpp0071468
    Conserved Domains (1) summary
    pfam01204
    Location:71 → 577
    Trehalase; Trehalase

  6. NM_166425.2 → NP_726027.1  trehalase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726027.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A5XCQ4
    Related
    FBpp0071467
    Conserved Domains (1) summary
    pfam01204
    Location:1 → 496
    Trehalase; Trehalase

  7. NM_166424.2 → NP_726026.1  trehalase, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726026.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0E903, Q0E904, Q7YWL2, Q961P0, Q9W2M1, Q9W2M2, Q9W2M3
    UniProtKB/TrEMBL
    A5XCQ1, A5XCQ4, A5XCQ9
    Related
    FBpp0071469
    Conserved Domains (1) summary
    pfam01204
    Location:71 → 577
    Trehalase; Trehalase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4UZR3 A4UZR3
Q9W2M2.1 Q9W2M2

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