akt1.S AKT serine/threonine kinase 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: akt1.S
Official Full Name: AKT serine/threonine kinase 1 S homeolog
Primary source: Xenbase:XB-GENE-484957
Locus tag: XELAEV_18041158mg
See related: EnsemblRapid:ENSXLAG00005034127
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: pkb; rac; xAct; akt-1; v-akt; v-akt1
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Genomic context

Location:: chromosome: 8S

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8S	NC_054386.1 (9890135..9987004)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8S	NC_030739.1 (9810476..9906787)

Chromosome 8S - NC_054386.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The regulation of Akt and FoxO transcription factors during dehydration in the African clawed frog (Xenopus laevis).
Title: The regulation of Akt and FoxO transcription factors during dehydration in the African clawed frog (Xenopus laevis).
These findings highlight novel and essential roles of PFKFB4 activity in later stages of neural crest (NC) development that are wired into the NC gene regulatory network.
Title: PFKFB4 control of AKT signaling is essential for premigratory and migratory neural crest formation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables potassium channel activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to epidermal growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within glucose metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of release of cytochrome c from mitochondria	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within organic substance transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peptidyl-serine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of endothelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of lipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of protein localization to cell surface	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to growth factor	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RAC-alpha serine/threonine-protein kinase

Names: AKT1 kinase; Akt; PKB alpha; RAC-PK-alpha; protein kinase Akt-1; protein kinase B, alpha; v-akt murine thymoma viral oncogene homolog 1 S homeolog; xAkt

NP_001083878.1

EC 2.7.11.1

XP_018087412.1

EC 2.7.11.1

XP_018087413.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090409.2 → NP_001083878.1 RAC-alpha serine/threonine-protein kinase

See identical proteins and their annotated locations for NP_001083878.1

Status: PROVISIONAL

Source sequence(s)

AF317656

UniProtKB/Swiss-Prot

Q98TY9

UniProtKB/TrEMBL

A0A974H862

Related

ENSXLAP00005102927.1, ENSXLAT00005104931.1

Conserved Domains (4) summary

cd01241
Location:4 → 111

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cd05594
Location:125 → 479

STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)

pfam00069
Location:151 → 409

Pkinase; Protein kinase domain

pfam00169
Location:6 → 106

PH; PH domain