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CACNA1D calcium voltage-gated channel subunit alpha1 D [ Gallus gallus (chicken) ]

Gene ID: 395895, updated on 17-Aug-2024

Summary

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Symbol
CACNA1Dprovided by CGNC
Full Name
calcium voltage-gated channel subunit alpha1 Dprovided by CGNC
Primary source
CGNC:49537
See related
Ensembl:ENSGALG00010027830
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Summary
This gene encodes a member of the voltage-dependent calcium channel protein subunit family. The cDNA for this gene was cloned from hair cells of the cochlea in the chicken inner ear. Study of the similar transmembrane protein in deficient mice reported impaired cardiac function and deafness, suggesting that the encoded protein is required for normal hearing and pacemaker activity in the heart. [provided by RefSeq, Aug 2012]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 12
Exon count:
54
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 12 NC_052543.1 (7231874..7397607)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 12 NC_052584.1 (7258746..7424552)

Chromosome 12 - NC_052543.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121106674 Neighboring gene transketolase Neighboring gene uncharacterized LOC121106676 Neighboring gene decapping mRNA 1A Neighboring gene choline dehydrogenase Neighboring gene ARP8 actin-related protein 8 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Development and regeneration of hair cells share common functional features. Levic S, et al. Proc Natl Acad Sci U S A, 2007 Nov 27. PMID 18025474, Free PMC Article
  2. Hair cell-specific splicing of mRNA for the alpha1D subunit of voltage-gated Ca2+ channels in the chicken's cochlea. Kollmar R, et al. Proc Natl Acad Sci U S A, 1997 Dec 23. PMID 9405709, Free PMC Article
  3. Predominance of the alpha1D subunit in L-type voltage-gated Ca2+ channels of hair cells in the chicken's cochlea. Kollmar R, et al. Proc Natl Acad Sci U S A, 1997 Dec 23. PMID 9405708, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables high voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of voltage-gated calcium channel complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
voltage-dependent L-type calcium channel subunit alpha-1D
Names
CHCACHA1D
L-type voltage-gated calcium channel alpha1D subunit ChCaChA1D
calcium channel, voltage-dependent, L type, alpha 1D subunit
voltage-gated calcium channel subunit alpha Cav1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205034.3 → NP_990365.1  voltage-dependent L-type calcium channel subunit alpha-1D

    See identical proteins and their annotated locations for NP_990365.1

    Status: REVIEWED

    Source sequence(s)
    JAENSK010000252
    UniProtKB/Swiss-Prot
    O73700, O73701, O73702, O73703, O73704
    UniProtKB/TrEMBL
    A0A8V1A5R9
    Related
    ENSGALP00010041246.1, ENSGALT00010067502.1
    Conserved Domains (4) summary
    pfam00520
    Location:138 → 412
    Ion_trans; Ion transport protein
    pfam08763
    Location:1577 → 1648
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1672 → 2187
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1512 → 1575
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    7231874..7397607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040646100.2 → XP_040502034.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X2

    UniProtKB/TrEMBL
    A0A8V1A5S5
    Conserved Domains (1) summary
    smart01062
    Location:1630 → 1660
    Ca_chan_IQ; Voltage gated calcium channel IQ domain

  2. XM_015292987.4 → XP_015148473.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X6

    UniProtKB/TrEMBL
    A0A8V1A5S5, A0A8V1ADG1
    Related
    ENSGALP00010041251.1, ENSGALT00010067508.1
    Conserved Domains (4) summary
    pfam00520
    Location:138 → 412
    Ion_trans; Ion transport protein
    pfam08763
    Location:1569 → 1640
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1664 → 2179
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1504 → 1567
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  3. XM_015292996.4 → XP_015148482.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X17

    UniProtKB/TrEMBL
    A0A1D5PY30, A0A8V1AHW6
    Related
    ENSGALP00010041258.1, ENSGALT00010067515.1
    Conserved Domains (4) summary
    pfam00520
    Location:1217 → 1455
    Ion_trans; Ion transport protein
    pfam08763
    Location:1528 → 1599
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1623 → 2129
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1463 → 1526
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  4. XM_040646099.2 → XP_040502033.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1

    UniProtKB/TrEMBL
    A0A8V1A5S5
    Conserved Domains (1) summary
    smart01062
    Location:1630 → 1660
    Ca_chan_IQ; Voltage gated calcium channel IQ domain

  5. XM_040646102.2 → XP_040502036.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X4

    UniProtKB/TrEMBL
    A0A8V1A5S5
    Conserved Domains (1) summary
    smart01062
    Location:1630 → 1660
    Ca_chan_IQ; Voltage gated calcium channel IQ domain

  6. XM_040646104.2 → XP_040502038.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X8

    UniProtKB/TrEMBL
    A0A8V1AHW6
    Conserved Domains (1) summary
    smart01062
    Location:1617 → 1647
    Ca_chan_IQ; Voltage gated calcium channel IQ domain

  7. XM_040646105.2 → XP_040502039.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X10

    UniProtKB/TrEMBL
    A0A8V1A5S5
    Related
    ENSGALP00010041245.1, ENSGALT00010067500.1
    Conserved Domains (1) summary
    smart01062
    Location:1602 → 1632
    Ca_chan_IQ; Voltage gated calcium channel IQ domain

  8. XM_040646107.2 → XP_040502041.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X13

    UniProtKB/TrEMBL
    A0A8V1AHW6
    Conserved Domains (1) summary
    smart01062
    Location:1589 → 1619
    Ca_chan_IQ; Voltage gated calcium channel IQ domain

  9. XM_046899820.1 → XP_046755776.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X5

    UniProtKB/TrEMBL
    A0A8V1A5S5

  10. XM_015292995.4 → XP_015148481.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X14

    UniProtKB/TrEMBL
    A0A8V1AHW6
    Conserved Domains (4) summary
    pfam00520
    Location:1217 → 1455
    Ion_trans; Ion transport protein
    pfam08763
    Location:1528 → 1599
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1623 → 2138
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1463 → 1526
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  11. XM_015293003.4 → XP_015148489.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X11

    UniProtKB/TrEMBL
    A0A8V1A5S5
    Conserved Domains (4) summary
    pfam00520
    Location:1217 → 1468
    Ion_trans; Ion transport protein
    pfam08763
    Location:1541 → 1612
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1636 → 2151
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1476 → 1539
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  12. XM_015293004.4 → XP_015148490.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X15

    UniProtKB/TrEMBL
    A0A8V1AAN9
    Conserved Domains (4) summary
    pfam00520
    Location:1217 → 1455
    Ion_trans; Ion transport protein
    pfam08763
    Location:1528 → 1599
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1623 → 2138
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1463 → 1526
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  13. XM_040646110.2 → XP_040502044.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X19

    UniProtKB/TrEMBL
    A0A8V1AAP3
    Conserved Domains (1) summary
    smart01062
    Location:1551 → 1581
    Ca_chan_IQ; Voltage gated calcium channel IQ domain

  14. XM_040646101.2 → XP_040502035.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X3

    UniProtKB/TrEMBL
    A0A8V1A5S5
    Conserved Domains (1) summary
    smart01062
    Location:1630 → 1660
    Ca_chan_IQ; Voltage gated calcium channel IQ domain

  15. XM_040646103.2 → XP_040502037.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X7

    UniProtKB/TrEMBL
    A0A8V1A5S5
    Conserved Domains (1) summary
    smart01062
    Location:1620 → 1650
    Ca_chan_IQ; Voltage gated calcium channel IQ domain

  16. XM_015292998.4 → XP_015148484.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X9

    UniProtKB/TrEMBL
    A0A8V1AHW6
    Conserved Domains (4) summary
    pfam00520
    Location:138 → 412
    Ion_trans; Ion transport protein
    pfam08763
    Location:1556 → 1627
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1651 → 2166
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1491 → 1554
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  17. XM_040646106.2 → XP_040502040.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X12

    UniProtKB/TrEMBL
    A0A8V1A5S5
    Related
    ENSGALP00010041249.1, ENSGALT00010067506.1
    Conserved Domains (1) summary
    smart01062
    Location:1592 → 1622
    Ca_chan_IQ; Voltage gated calcium channel IQ domain

  18. XM_015293001.4 → XP_015148487.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X16

    UniProtKB/TrEMBL
    A0A8V1AAN9
    Conserved Domains (4) summary
    pfam00520
    Location:1217 → 1455
    Ion_trans; Ion transport protein
    pfam08763
    Location:1528 → 1599
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1623 → 2138
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1463 → 1526
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  19. XM_040646109.1 → XP_040502043.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X18

    UniProtKB/TrEMBL
    A0A8V1A5S5
    Conserved Domains (1) summary
    smart01062
    Location:1567 → 1597
    Ca_chan_IQ; Voltage gated calcium channel IQ domain

  20. XM_040646111.2 → XP_040502045.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X20

    UniProtKB/TrEMBL
    A0A8V1A5S5
    Conserved Domains (1) summary
    smart01062
    Location:1233 → 1263
    Ca_chan_IQ; Voltage gated calcium channel IQ domain

  21. XM_040646112.1 → XP_040502046.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X21

    Conserved Domains (1) summary
    smart01062
    Location:1191 → 1221
    Ca_chan_IQ; Voltage gated calcium channel IQ domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052584.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    7258746..7424552
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046926072.1 → XP_046782028.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X2

    UniProtKB/TrEMBL
    A0A8V1A5S5

  2. XM_046926076.1 → XP_046782032.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X6

    UniProtKB/TrEMBL
    A0A8V1A5S5, A0A8V1ADG1

  3. XM_046926087.1 → XP_046782043.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X17

    UniProtKB/TrEMBL
    A0A1D5PY30, A0A8V1AHW6

  4. XM_046926071.1 → XP_046782027.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1

    UniProtKB/TrEMBL
    A0A8V1A5S5

  5. XM_046926074.1 → XP_046782030.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X4

    UniProtKB/TrEMBL
    A0A8V1A5S5

  6. XM_046926078.1 → XP_046782034.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X8

    UniProtKB/TrEMBL
    A0A8V1AHW6

  7. XM_046926080.1 → XP_046782036.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X10

    UniProtKB/TrEMBL
    A0A8V1A5S5

  8. XM_046926083.1 → XP_046782039.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X13

    UniProtKB/TrEMBL
    A0A8V1AHW6

  9. XM_046926075.1 → XP_046782031.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X5

    UniProtKB/TrEMBL
    A0A8V1A5S5

  10. XM_046926084.1 → XP_046782040.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X14

    UniProtKB/TrEMBL
    A0A8V1AHW6

  11. XM_046926081.1 → XP_046782037.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X11

    UniProtKB/TrEMBL
    A0A8V1A5S5

  12. XM_046926085.1 → XP_046782041.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X15

    UniProtKB/TrEMBL
    A0A8V1AAN9

  13. XM_046926089.1 → XP_046782045.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X19

    UniProtKB/TrEMBL
    A0A8V1AAP3

  14. XM_046926073.1 → XP_046782029.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X3

    UniProtKB/TrEMBL
    A0A8V1A5S5

  15. XM_046926077.1 → XP_046782033.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X7

    UniProtKB/TrEMBL
    A0A8V1A5S5

  16. XM_046926079.1 → XP_046782035.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X9

    UniProtKB/TrEMBL
    A0A8V1AHW6

  17. XM_046926082.1 → XP_046782038.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X12

    UniProtKB/TrEMBL
    A0A8V1A5S5

  18. XM_046926086.1 → XP_046782042.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X16

    UniProtKB/TrEMBL
    A0A8V1AAN9

  19. XM_046926088.1 → XP_046782044.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X18

    UniProtKB/TrEMBL
    A0A8V1A5S5

  20. XM_046926090.1 → XP_046782046.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X20

    UniProtKB/TrEMBL
    A0A8V1A5S5

  21. XM_046926091.1 → XP_046782047.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X21

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O73700.1 GenPept UniProtKB/Swiss-Prot:O73700

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