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Als2cl ALS2 C-terminal like [ Rattus norvegicus (Norway rat) ]

Gene ID: 316017, updated on 18-Sep-2024

Summary

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Official Symbol
Als2clprovided by RGD
Official Full Name
ALS2 C-terminal likeprovided by RGD
Primary source
RGD:1305208
See related
EnsemblRapid:ENSRNOG00000033921 AllianceGenome:RGD:1305208
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305208
Summary
Predicted to enable identical protein binding activity and small GTPase binding activity. Predicted to act upstream of or within endosome organization and protein localization. Predicted to be located in cytoplasmic vesicle. Orthologous to human ALS2CL (ALS2 C-terminal like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 65.9), Lung (RPKM 52.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Als2cl in Genome Data Viewer
Location:
8q32
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (119746498..119762824)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (110863753..110884434)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (119156081..119176680)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene serine protease 50 Neighboring gene transmembrane inner ear Neighboring gene uncharacterized LOC120094265 Neighboring gene family with sequence similarity 240 member A Neighboring gene uncharacterized LOC134480239

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics. Hadano S, et al. FEBS Lett, 2004 Sep 24. PMID 15388334
  2. ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics. Suzuki-Utsunomiya K, et al. Biochem Biophys Res Commun, 2007 Mar 9. PMID 17239822
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ALS2 C-terminal-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    119746498..119762824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082651.2 → XP_038938579.1  ALS2 C-terminal-like protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6AEV4, D3ZG75
    Related
    ENSRNOP00000043561.2, ENSRNOT00000046745.6
    Conserved Domains (3) summary
    PLN03185
    Location:357 → 550
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    cl19569
    Location:835 → 937
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    cl17171
    Location:223 → 321
    PH-like; Pleckstrin homology-like domain

  2. XM_039082659.2 → XP_038938587.1  ALS2 C-terminal-like protein isoform X2

    Conserved Domains (2) summary
    PLN03185
    Location:357 → 550
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    cl17171
    Location:223 → 321
    PH-like; Pleckstrin homology-like domain

  3. XM_039082661.2 → XP_038938589.1  ALS2 C-terminal-like protein isoform X3

    Conserved Domains (2) summary
    PLN03185
    Location:357 → 550
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    cl17171
    Location:223 → 321
    PH-like; Pleckstrin homology-like domain

  4. XM_039082662.2 → XP_038938590.1  ALS2 C-terminal-like protein isoform X4

    Conserved Domains (2) summary
    PLN03185
    Location:357 → 550
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    cl17171
    Location:223 → 321
    PH-like; Pleckstrin homology-like domain

  5. XM_039082664.2 → XP_038938592.1  ALS2 C-terminal-like protein isoform X6

    Conserved Domains (2) summary
    PLN03185
    Location:357 → 394
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    cl17171
    Location:223 → 321
    PH-like; Pleckstrin homology-like domain

  6. XM_039082663.2 → XP_038938591.1  ALS2 C-terminal-like protein isoform X5

    Conserved Domains (2) summary
    PLN03185
    Location:2 → 187
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    cl19569
    Location:472 → 574
    VPS9; Vacuolar sorting protein 9 (VPS9) domain

RNA

  1. XR_005488472.2 RNA Sequence

  2. XR_005488473.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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