cysl-2 Bifunctional L-3-cyanoalanine synthase/cysteine synthase [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: cysl-2
Gene description: Bifunctional L-3-cyanoalanine synthase/cysteine synthase
Primary source: WormBase:WBGene00010759
Locus tag: CELE_K10H10.2
See related: AllianceGenome:WB:WBGene00010759
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables L-3-cyanoalanine synthase activity and cysteine synthase activity. Involved in cysteine biosynthetic process from serine. Predicted to be active in cytoplasm. Is expressed in hypodermis and pharynx. Used to study Down syndrome. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See cysl-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 3

Sequence:: Chromosome: II; NC_003280.10 (14492874..14494451, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These observations establish a CYSL-1, CYSL-2, and RHY-1 dependent mechanism by which animals heritably adapt to infection.
Title: Cysteine synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection.
CYSL-1 interacts with EGL-9 and activates HIF-1 that upregulates expression of genes detoxifying sulfide and cyanide, the CYSL-2 acts as a cyanoalanine synthase in the cyanide detoxification pathway and simultaneously produces hydrogen sulfide
Title: Biochemical properties of nematode O-acetylserine(thiol)lyase paralogs imply their distinct roles in hydrogen sulfide homeostasis.
Data indicate that genes sqrd-1, ethe-1, cysl-1, cysl-2 and HIF-1 are involved in survival to hydrogen sulfide and hydrogen cyanide.
Title: The response of Caenorhabditis elegans to hydrogen sulfide and hydrogen cyanide.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K10H10.2 (e-PCR)
- UniSTS:307805

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables L-3-cyanoalanine synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-3-cyanoalanine synthase activity	IEA Inferred from Electronic Annotation more info
enables cysteine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine synthase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cysteine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cysteine biosynthetic process from serine	IBA Inferred from Biological aspect of Ancestor more info
involved_in cysteine biosynthetic process from serine	IDA Inferred from Direct Assay more info	PubMed
involved_in cysteine biosynthetic process from serine	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Bifunctional L-3-cyanoalanine synthase/cysteine synthase

NP_497008.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

14492874..14494451 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064607.6 → NP_497008.1 Bifunctional L-3-cyanoalanine synthase/cysteine synthase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497008.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O45679

Conserved Domains (2) summary

cd01561
Location:15 → 305

CBS_like; CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. ...

PLN02565
Location:12 → 320

PLN02565; cysteine synthase