ceh-12 Homeobox domain-containing protein;Homeobox protein ceh-12 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: ceh-12
Gene description: Homeobox domain-containing protein;Homeobox protein ceh-12
Primary source: WormBase:WBGene00000436
Locus tag: CELE_F33D11.4
See related: AllianceGenome:WB:WBGene00000436
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable sequence-specific double-stranded DNA binding activity. Predicted to be involved in central nervous system development and neuron projection morphogenesis. Predicted to be active in nucleus. Is expressed in VB neuron; ventral nerve cord; and vulval muscle. Human ortholog(s) of this gene implicated in Currarino syndrome. Orthologous to human MNX1 (motor neuron and pancreas homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: I

Exon count:: 4

Sequence:: Chromosome: I; NC_003279.8 (5840282..5841940)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F33D11.4 (e-PCR)
- UniSTS:319298

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Homeobox domain-containing protein;Homeobox protein ceh-12

NP_001309522.1

Confirmed by transcript evidence

NP_491693.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

5840282..5841940

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059292.2 → NP_491693.1 Homeobox protein ceh-12 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491693.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P17487, Q9TZZ7

Conserved Domains (1) summary

pfam00046
Location:113 → 166

Homeobox; Homeobox domain
NM_001322676.1 → NP_001309522.1 Homeobox domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A131MAP5

Conserved Domains (1) summary

pfam00046
Location:4 → 58

Homeobox; Homeobox domain