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si:dkey-22f5.9 si:dkey-22f5.9 [ Danio rerio (zebrafish) ]

Gene ID: 100526813, updated on 18-Sep-2024

Summary

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Official Symbol
si:dkey-22f5.9provided by ZNC
Official Full Name
si:dkey-22f5.9provided by ZNC
Primary source
ZFIN:ZDB-GENE-091204-260
See related
Ensembl:ENSDARG00000092044 AllianceGenome:ZFIN:ZDB-GENE-091204-260
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide. Predicted to act upstream of or within defense response to bacterium. Predicted to be located in extracellular region. Orthologous to human LEAP2 (liver enriched antimicrobial peptide 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 21
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (30651064..30658545, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (30614367..30621828, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene wu:fj42b12 Neighboring gene phosphorylase kinase, alpha 1b (muscle) Neighboring gene uncharacterized LOC137488829 Neighboring gene chloride channel, voltage-sensitive 5a Neighboring gene tumor necrosis factor (ligand) superfamily, member 10 like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Effects of difenoconazole on hepatotoxicity, lipid metabolism and gut microbiota in zebrafish (Danio rerio). Jiang J, et al. Environ Pollut, 2020 Oct. PMID 32480235
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within defense response to bacterium IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
liver-expressed antimicrobial peptide 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001386361.1 → NP_001373290.1  liver-expressed antimicrobial peptide 2-like precursor

    Status: VALIDATED

    Source sequence(s)
    BX511168
    UniProtKB/TrEMBL
    A0A8M1RP63, E9QG21
    Related
    ENSDARP00000115590.1, ENSDART00000139764.2
    Conserved Domains (1) summary
    pfam07359
    Location:13 → 88
    LEAP-2; Liver-expressed antimicrobial peptide 2 precursor (LEAP-2)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    30651064..30658545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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