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    EVM150 kelch-like protein [ Ectromelia virus ]

    Gene ID: 951507, updated on 18-Aug-2023

    Summary

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    Gene symbol
    EVM150
    Gene description
    kelch-like protein
    Locus tag
    ECTVgp151
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Ectromelia virus (strain: Moscow)
    Lineage
    Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes; Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus
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    Genomic context

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    Sequence:
    NC_004105.1 (168929..170620)

    NC_004105.1Genomic Context describing neighboring genes Neighboring gene EVM148 Neighboring gene EVM149 Neighboring gene EVM151 Neighboring gene EVM152

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004105.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ectromelia virus encodes a BTB/kelch protein, EVM150, that inhibits NF-κB signaling. Wang Q, et al. J Virol, 2014 May. PMID 24522926, Free PMC Article
    2. Ectromelia virus BTB/kelch proteins, EVM150 and EVM167, interact with cullin-3-based ubiquitin ligases. Wilton BA, et al. Virology, 2008 Apr 25. PMID 18221766, Free PMC Article
    3. Analysis of host response modifier ORFs of ectromelia virus, the causative agent of mousepox. Chen N, et al. Virus Res, 2000 Feb. PMID 10725549
    4. A novel poxvirus gene and its human homolog are similar to an E. coli lysophospholipase. Wall EM, et al. Virus Res, 1997 Dec. PMID 9495531
    5. Species specificity of ectromelia virus and vaccinia virus interferon-gamma binding proteins. Mossman K, et al. Virology, 1995 Apr 20. PMID 7747448

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Significantly, expression of the BTB-only domain of EVM150 blocked NF-kappaB activation.
      Title: Ectromelia virus encodes a BTB/kelch protein, EVM150, that inhibits NF-κB signaling.
    2. Findings suggest that the ectromelia virus-encoded BTB/kelch proteins, EVM150 and EVM167, interact with cullin-3 potentially functioning to recruit unidentified substrates for ubiquitination.
      Title: Ectromelia virus BTB/kelch proteins, EVM150 and EVM167, interact with cullin-3-based ubiquitin ligases.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    kelch-like protein
    NP_671669.1
    • Kelch-like protein; Kelch motifs are 50-amino acid motifs represented by one beta-sheet blade; may be involved in remodelling and stabilization of the host cytoskeleton and host immune evasion; BTB-Kelch proteins have Kelch repeats that can interact with actin filaments; the poxviridae are enveloped unsegmented dsDNA viruses; unlike many dsDNA viruses that replicate in the host nucleus poxviruses encode their own replication machinery and therefore replicate in the cytoplasm; viral genes are expressed in a bi-phasic manner with early genes genes encoding non-structural proteins involved in genome replication and late genes encoding the viral structural proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004105.1 Reference assembly

      Range
      168929..170620
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_671669.1 kelch-like protein [Ectromelia virus]

      See identical proteins and their annotated locations for NP_671669.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q8JL69
      UniProtKB/TrEMBL
      A0A075INR2, A0A2I6SFF4, A0A8A2HEC4, I0AZN2
      Conserved Domains (2) summary
      PHA03098
      Location:14 → 550
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:336 → 381
      Kelch; KELCH repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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