TMM Leucine-rich repeat (LRR) family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: TMM
Gene description: Leucine-rich repeat (LRR) family protein
Primary source: Araport:AT1G80080
Locus tag: AT1G80080
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtRLP17; F18B13.16; F18B13_16; Receptor Like Protein 17; TOO MANY MOUTHS
Summary: Encodes a transmembrane leucine-repeat containing receptor-like protein that is expressed in proliferative postprotodermal cells. Recessive mutation leads to disruption of asymmetric cell division during stomata development. Its transcript levels change after inducing MUTE expression in a mute background.
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Genomic context

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Location:: chromosome: 1

Exon count:: 1

Sequence:: Chromosome: 1; NC_003070.9 (30127819..30129649, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data demonstrate that TMM dictates the specificity of ERECTA family for the perception of different epidermal patterning factor peptides (EPfs), thus functioning as a specificity switch for the regulation of the activities of ERfs.
Title: A receptor-like protein acts as a specificity switch for the regulation of stomatal development.
The tmm-1 mutation is epistatic to the atgpi8-1 mutation, indicating that either TMM is a GPI-AP or there is another GPI-AP regulating stomata development whose function is dependent upon TMM.
Title: A Mutation in the Catalytic Subunit of the Glycosylphosphatidylinositol Transamidase Disrupts Growth, Fertility, and Stomata Formation.
Brassinosteroid organ-specific effects on stomatal production might coordinate with the TMM organ-specific actions.
Title: Organ-specific effects of brassinosteroids on stomatal production coordinate with the action of Too Many Mouths.
TMM was involved in Abscisic Acid (ABA) signaling transduction. Overexpression of TMM resulted in the reduction of leaf trichomes and their branches.
Title: New phenotypic characteristics of three tmm alleles in Arabidopsis thaliana.
CHAL and the EPFs both act through ER family receptors to repress stomatal production, but are subject to opposite regulation by TMM
Title: Regional specification of stomatal production by the putative ligand CHALLAH.
TMM interacts with other proteins to modulate precursor cell fate and progression in an organ and domain-specific manner.
Title: TOO MANY MOUTHS promotes cell fate progression in stomatal development of Arabidopsis stems.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_106657.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables peptide binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor serine/threonine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to abscisic acid stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of antifungal innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to abscisic acid	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IC Inferred by Curator more info	PubMed
involved_in stomatal complex formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stomatal complex morphogenesis	IMP Inferred from Mutant Phenotype more info
involved_in stomatal complex patterning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trichome morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: Leucine-rich repeat (LRR) family protein

NP_178125.1

TOO MANY MOUTHS (TMM); CONTAINS InterPro DOMAIN/s: Leucine-rich repeat (InterPro:IPR001611); BEST Arabidopsis thaliana protein match is: receptor like protein 29 (TAIR:AT2G42800.1); Has 88991 Blast hits to 28047 proteins in 1079 species: Archae - 16; Bacteria - 3330; Metazoa - 23111; Fungi - 805; Plants - 56845; Viruses - 0; Other Eukaryotes - 4884 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

30127819..30129649 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_106657.3 → NP_178125.1 Leucine-rich repeat (LRR) family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_178125.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8GWY1, Q9SSD1

UniProtKB/TrEMBL

A0A178WJY8, A0A5S9WW10

Conserved Domains (2) summary

PLN00113
Location:150 → 392

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:161 → 184

LRR_RI; leucine-rich repeat [structural motif]