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    MCM2 minichromosome maintenance (MCM2/3/5) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841056, updated on 15-Feb-2024

    Summary

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    Gene symbol
    MCM2
    Gene description
    minichromosome maintenance (MCM2/3/5) family protein
    Primary source
    Araport:AT1G44900
    Locus tag
    AT1G44900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMCM2; MINICHROMOSOME MAINTENANCE 2; T12C22.19; T12C22_19
    Summary
    Encodes MCM2 (MINICHROMOSOME MAINTENANCE 2), a protein essential to embryo development. Overexpression results in altered root meristem function.
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    16
    Sequence:
    Chromosome: 1; NC_003070.9 (16970214..16974753)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene inner membrane OXA1-like protein Neighboring gene minichromosone maintenance protein Neighboring gene pre-mRNA-processing protein 40A Neighboring gene uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis MCM2 gene is essential to embryo development and its over-expression alters root meristem function. Ni DA, et al. New Phytol, 2009 Oct. PMID 19650778
    2. Arabidopsis thaliana MCM2 plays role(s) in mungbean yellow mosaic India virus (MYMIV) DNA replication. Suyal G, et al. Arch Virol, 2013 May. PMID 23242774
    3. Dynamic localization of the DNA replication proteins MCM5 and MCM7 in plants. Shultz RW, et al. Plant Physiol, 2009 Jun. PMID 19357199, Free PMC Article
    4. The DNA replication checkpoint aids survival of plants deficient in the novel replisome factor ETG1. Takahashi N, et al. EMBO J, 2008 Jul 9. PMID 18528439, Free PMC Article
    5. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Van Leene J, et al. Mol Syst Biol, 2010 Aug 10. PMID 20706207, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001198225.2
    NM_103572.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA unwinding involved in DNA replication TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of root meristem growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MCM complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of THO complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    minichromosome maintenance (MCM2/3/5) family protein
    NP_001185154.1
    • MINICHROMOSOME MAINTENANCE 2 (MCM2); FUNCTIONS IN: DNA-dependent ATPase activity, DNA binding, ATP binding; INVOLVED IN: in 7 processes; LOCATED IN: nuclear chromatin; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), DNA-dependent ATPase MCM (InterPro:IPR001208), DNA-dependent ATPase MCM, conserved site (InterPro:IPR018525), MCM protein 2 (InterPro:IPR008045), MCM protein 2, N-terminal (InterPro:IPR021092); BEST Arabidopsis thaliana protein match is: Minichromosome maintenance (MCM2/3/5) family protein (TAIR:AT2G16440.1).
    NP_175112.2
    • MINICHROMOSOME MAINTENANCE 2 (MCM2); FUNCTIONS IN: DNA-dependent ATPase activity, DNA binding, ATP binding; INVOLVED IN: in 7 processes; LOCATED IN: nuclear chromatin; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), DNA-dependent ATPase MCM (InterPro:IPR001208), DNA-dependent ATPase MCM, conserved site (InterPro:IPR018525), MCM protein 2 (InterPro:IPR008045), MCM protein 2, N-terminal (InterPro:IPR021092); BEST Arabidopsis thaliana protein match is: Minichromosome maintenance (MCM2/3/5) family protein (TAIR:AT2G16440.1); Has 6038 Blast hits to 5672 proteins in 1024 species: Archae - 381; Bacteria - 1139; Metazoa - 1602; Fungi - 1087; Plants - 469; Viruses - 28; Other Eukaryotes - 1332 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      16970214..16974753
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198225.2 → NP_001185154.1  minichromosome maintenance (MCM2/3/5) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185154.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W5C3, F4HPK7
      Conserved Domains (4) summary
      smart00350
      Location:318 → 826
      MCM; minichromosome maintenance proteins
      pfam12619
      Location:67 → 136
      MCM2_N; Mini-chromosome maintenance protein 2
      pfam14551
      Location:219 → 334
      MCM_N; MCM N-terminal domain
      cl21455
      Location:542 → 681
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_103572.5 → NP_175112.2  minichromosome maintenance (MCM2/3/5) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175112.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q96275, Q9LPD9
      UniProtKB/TrEMBL
      A0A178W5C3
      Conserved Domains (3) summary
      smart00350
      Location:320 → 828
      MCM; minichromosome maintenance proteins
      pfam12619
      Location:67 → 138
      MCM2_N; Mini-chromosome maintenance protein 2
      pfam14551
      Location:222 → 313
      MCM_N; MCM N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LPD9.1

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