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    EMF2 VEFS-Box of polycomb protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835198, updated on 15-Oct-2023

    Summary

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    Gene symbol
    EMF2
    Gene description
    VEFS-Box of polycomb protein
    Primary source
    Araport:AT5G51230
    Locus tag
    AT5G51230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AT5G51240; AtEMF2; CYR1; CYTOKININ RESISTANT 1; EMBRYONIC FLOWER 2; MWD22.18; MWD22_18; VEF2
    Summary
    Polycomb group protein with zinc finger domain involved in negative regulation of reproductive development. Forms a complex with FIE, CLF, and MSI1. This complex modulates the expression of target genes including AG, PI and AP3.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    22
    Sequence:
    Chromosome: 5; NC_003076.8 (20823644..20829644)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene oleosin3 Neighboring gene ubiquinol-cytochrome C chaperone family protein Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene HAD superfamily, subfamily IIIB acid phosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EMBRYONIC FLOWER2, a novel polycomb group protein homolog, mediates shoot development and flowering in Arabidopsis. Yoshida N, et al. Plant Cell, 2001 Nov. PMID 11701882, Free PMC Article
    2. EMF genes regulate Arabidopsis inflorescence development. Chen L, et al. Plant Cell, 1997 Nov. PMID 9401124, Free PMC Article
    3. EMF1 and PRC2 cooperate to repress key regulators of Arabidopsis development. Kim SY, et al. PLoS Genet, 2012. PMID 22457632, Free PMC Article
    4. Synergistic repression of the embryonic programme by SET DOMAIN GROUP 8 and EMBRYONIC FLOWER 2 in Arabidopsis seedlings. Tang X, et al. J Exp Bot, 2012 Feb. PMID 22162868, Free PMC Article
    5. Epigenetic regulation of gene programs by EMF1 and EMF2 in Arabidopsis. Kim SY, et al. Plant Physiol, 2010 Feb. PMID 19783648, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knock-out mutants in identified candidate genes (CYR1, At1g32360 and RLP48) were isolated and differences in root hair traits in the mutants were confirmed.
      Title: Uncovering genes and ploidy involved in the high diversity in root hair density, length and response to local scarce phosphate in Arabidopsis thaliana.
    2. to promote vegetative development and to regulate cell differentiation during shoot and root organogenesis, EMF1 binds genes required for other developmental phases. These are primarily genes trimethylated by EMF2-PRC2 on their H3K27
      Title: EMF1 and PRC2 cooperate to repress key regulators of Arabidopsis development.
    3. The observations demonstrate a functional cooperative interplay between SDG8 and an EMF2-containing PcG complex in maintaining vegetative cell identity by repressing seed genes to promote seedling development.
      Title: Synergistic repression of the embryonic programme by SET DOMAIN GROUP 8 and EMBRYONIC FLOWER 2 in Arabidopsis seedlings.
    4. EMF1 and EMF2 target transcription factor genes to mediate vegetative development and stress responses, and regulate flowering time genes.
      Title: Epigenetic regulation of gene programs by EMF1 and EMF2 in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001125941.1
    NM_124502.3
    NM_180837.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within epigenetic programming in the endosperm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    VEFS-Box of polycomb protein
    NP_001119413.1
    • EMBRYONIC FLOWER 2 (EMF2); CONTAINS InterPro DOMAIN/s: Zinc finger, C2H2-like (InterPro:IPR015880), Polycomb protein, VEFS-Box (InterPro:IPR019135); BEST Arabidopsis thaliana protein match is: VEFS-Box of polycomb protein (TAIR:AT4G16845.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_199936.2
    • EMBRYONIC FLOWER 2 (EMF2); CONTAINS InterPro DOMAIN/s: Zinc finger, C2H2-like (InterPro:IPR015880), Polycomb protein, VEFS-Box (InterPro:IPR019135); BEST Arabidopsis thaliana protein match is: VEFS-Box of polycomb protein (TAIR:AT4G16845.1); Has 297 Blast hits to 235 proteins in 79 species: Archae - 0; Bacteria - 0; Metazoa - 134; Fungi - 2; Plants - 148; Viruses - 0; Other Eukaryotes - 13 (source: NCBI BLink).
    NP_851168.1
    • EMBRYONIC FLOWER 2 (EMF2); CONTAINS InterPro DOMAIN/s: Polycomb protein, VEFS-Box (InterPro:IPR019135); BEST Arabidopsis thaliana protein match is: VEFS-Box of polycomb protein (TAIR:AT4G16845.1); Has 297 Blast hits to 235 proteins in 79 species: Archae - 0; Bacteria - 0; Metazoa - 134; Fungi - 2; Plants - 148; Viruses - 0; Other Eukaryotes - 13 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      20823644..20829644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180837.3 → NP_851168.1  VEFS-Box of polycomb protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851168.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53XQ5, Q8L6Y4, Q93V59, Q9LU50, Q9LU51
      UniProtKB/TrEMBL
      A0A178UM24, A0A5S9YD93, A0A7G2FG09
      Conserved Domains (1) summary
      pfam09733
      Location:488 → 624
      VEFS-Box; VEFS-Box of polycomb protein

    2. NM_124502.3 → NP_199936.2  VEFS-Box of polycomb protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199936.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2FG09
      Conserved Domains (1) summary
      pfam09733
      Location:483 → 619
      VEFS-Box; VEFS-Box of polycomb protein

    3. NM_001125941.1 → NP_001119413.1  VEFS-Box of polycomb protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001119413.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2FG09
      Conserved Domains (1) summary
      pfam09733
      Location:483 → 619
      VEFS-Box; VEFS-Box of polycomb protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L6Y4.2

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