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    UAH ureidoglycolate amidohydrolase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834380, updated on 7-Sep-2023

    Summary

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    Gene symbol
    UAH
    Gene description
    ureidoglycolate amidohydrolase
    Primary source
    Araport:AT5G43600
    Locus tag
    AT5G43600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA ALLANTOATE AMIDOHYDROLASE 2; ATAAH-2; K9D7.10; K9D7_10; ureidoglycolate amidohydrolase
    Summary
    Encodes a protein with ureidoglycolate amidohydrolase activity in vitro. It is 27% identical and 43% similar to the E. coli allantoate amidohydrolase (AAH), but, in vitro assays with purified protein and allantoate as a substrate do not show any increase in ammonium concentration, indicating that there this enzyme has no AAH activity.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    12
    Sequence:
    Chromosome: 5; NC_003076.8 (17512440..17515513)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Serine protease inhibitor, potato inhibitor I-type family protein Neighboring gene Acyl transferase/acyl hydrolase/lysophospholipase superfamily protein Neighboring gene miscRNA Neighboring gene sucrose-proton symporter 6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural insights into the substrate specificity of (s)-ureidoglycolate amidohydrolase and its comparison with allantoate amidohydrolase. Shin I, et al. J Mol Biol, 2014 Aug 26. PMID 25020232
    2. Identification, biochemical characterization, and subcellular localization of allantoate amidohydrolases from Arabidopsis and soybean. Werner AK, et al. Plant Physiol, 2008 Feb. PMID 18065556, Free PMC Article
    3. The ureide-degrading reactions of purine ring catabolism employ three amidohydrolases and one aminohydrolase in Arabidopsis, soybean, and rice. Werner AK, et al. Plant Physiol, 2013 Oct. PMID 23940254, Free PMC Article
    4. Ureide catabolism in Arabidopsis thaliana and Escherichia coli. Werner AK, et al. Nat Chem Biol, 2010 Jan. PMID 19935661
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural analyses of Arabidopsis UAH revealed a distinct binding mode for each ligand in a bimetal reaction center with the active site in a closed conformation.
      Title: Structural insights into the substrate specificity of (s)-ureidoglycolate amidohydrolase and its comparison with allantoate amidohydrolase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_123726.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables allantoate deiminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ureidoglycolate hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within allantoin catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in allantoin catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within purine nucleobase catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within ureide catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    ureidoglycolate amidohydrolase
    NP_199173.2
    • ureidoglycolate amidohydrolase (UAH); FUNCTIONS IN: metallopeptidase activity, ureidoglycolate hydrolase activity; INVOLVED IN: proteolysis, allantoin catabolic process; LOCATED IN: endomembrane system; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase M20 (InterPro:IPR002933), Amidase, hydantoinase/carbamoylase (InterPro:IPR010158), Peptidase M20, dimerisation (InterPro:IPR011650); BEST Arabidopsis thaliana protein match is: allantoate amidohydrolase (TAIR:AT4G20070.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      17512440..17515513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123726.4 → NP_199173.2  ureidoglycolate amidohydrolase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199173.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VXY9, Q9FIY0
      UniProtKB/TrEMBL
      A0A5S9YBS7, A0A654G7Q2
      Conserved Domains (1) summary
      cd03884
      Location:66 → 471
      M20_bAS; M20 Peptidase beta-alanine synthase, an amidohydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VXY9.1

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