APC4 Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: APC4
Gene description: Transducin/WD40 repeat-like superfamily protein
Primary source: Araport:AT4G21530
Locus tag: AT4G21530
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: anaphase promoting complex 4; F18E5.150; F18E5_150
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Genomic context

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Location:: chromosome: 4

Exon count:: 19

Sequence:: Chromosome: 4; NC_003075.7 (11450552..11456007)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arabidopsis APC4 plays critical roles in female gametogenesis and embryogenesis, possibly as a connector in APC/C, and that regulation of auxin distribution may be involved in these processes.
Title: The Arabidopsis APC4 subunit of the anaphase-promoting complex/cyclosome (APC/C) is critical for both female gametogenesis and embryogenesis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_118273.8

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in anaphase-promoting complex-dependent catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant ovule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Transducin/WD40 repeat-like superfamily protein

NP_193884.6

Transducin/WD40 repeat-like superfamily protein; CONTAINS InterPro DOMAIN/s: WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), WD40 repeat, subgroup (InterPro:IPR019781); Has 2387 Blast hits to 1893 proteins in 265 species: Archae - 2; Bacteria - 820; Metazoa - 693; Fungi - 413; Plants - 211; Viruses - 0; Other Eukaryotes - 248 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

11450552..11456007

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_118273.8 → NP_193884.6 Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_193884.6

Status: REVIEWED

UniProtKB/Swiss-Prot

O65418

UniProtKB/TrEMBL

A0A5S9XUH2

Conserved Domains (5) summary

COG2319
Location:29 → 192

WD40; WD40 repeat [General function prediction only]

pfam12894
Location:14 → 60

ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain

pfam12896
Location:268 → 470

ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4

sd00039
Location:68 → 104

7WD40; WD40 repeat [structural motif]

cl02567
Location:32 → 120

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...