RPN1A 26S proteasome regulatory subunit S2 1A [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: RPN1A
Gene description: 26S proteasome regulatory subunit S2 1A
Primary source: Araport:AT2G20580
Locus tag: AT2G20580
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: 26S proteasome regulatory subunit S2 1A; 26S PROTEASOME REGULATORY SUBUNIT S2 1A; ATRPN1A; F23N11.10; F23N11_10
Summary: encoding the RPN subunits of the 26S proteasome
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Genomic context

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Location:: chromosome: 2

Exon count:: 23

Sequence:: Chromosome: 2; NC_003071.7 (8858962..8864865)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results demonstrate that RPN1a may be involved in trichome development through the GA and CK signaling pathways.
Title: RPN1a, a subunit of the 26S proteasome, controls trichome development in Arabidopsis.
Mutations in the Arabidopsis 26S proteasome regulatory subunit RPN1a suppressed edr2-associated phenotypes. the rpn1a mutant showed enhanced susceptibility to virulent and avirulent pathogens. RPN1a plays an important role in defense responses.
Title: RPN1a, a 26S proteasome subunit, is required for innate immunity in Arabidopsis.
Data indicate that overexpression of microtubule regulatory protein WDL3 (At3g23090) inhibited etiolated hypocotyl growth in regulatory particle non-ATPase subunit-1a mutant (rpn1a-4; At2g20580) plants but not in wild-type seedlings.
Title: Light-regulated hypocotyl elongation involves proteasome-dependent degradation of the microtubule regulatory protein WDL3 in Arabidopsis.
RPN1a is required for all developmental processes regulated by the 26SP, and it does not have a specific function in embryo development.
Title: The Arabidopsis 26S proteasome subunit RPN1a is required for optimal plant growth and stress responses.
RPN1 activity is essential during embryogenesis, where it might participate in the destruction of a specific set of protein substrates.[RPN1a]
Title: The RPN1 subunit of the 26S proteasome in Arabidopsis is essential for embryogenesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MASC_STS17633 (e-PCR)
- UniSTS:258975

Homology

Orthologs from OrthoDB

NM_127618.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables enzyme regulator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein catabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in response to salicylic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed
located_in plasmodesma	HDA more info	PubMed
part_of proteasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle, base subcomplex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 26S proteasome regulatory subunit S2 1A

NP_565477.1

26S proteasome regulatory subunit S2 1A (RPN1A); FUNCTIONS IN: enzyme regulator activity, binding; INVOLVED IN: regulation of cell cycle, protein catabolic process, ubiquitin-dependent protein catabolic process; LOCATED IN: proteasome regulatory particle, base subcomplex, proteasome complex, nucleus, plasma membrane; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit (InterPro:IPR016643), Armadillo-type fold (InterPro:IPR016024), Proteasome/cyclosome, regulatory subunit (InterPro:IPR002015); BEST Arabidopsis thaliana protein match is: 26S proteasome regulatory subunit S2 1B (TAIR:AT4G28470.1); Has 1002 Blast hits to 968 proteins in 295 species: Archae - 0; Bacteria - 4; Metazoa - 376; Fungi - 294; Plants - 141; Viruses - 0; Other Eukaryotes - 187 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

8858962..8864865

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_127618.4 → NP_565477.1 26S proteasome regulatory subunit S2 1A [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_565477.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q56ZR0, Q9C5J1, Q9SIV2

UniProtKB/TrEMBL

A0A178VZC8, A0A5S9WZL4

Conserved Domains (1) summary

COG5110
Location:4 → 891

RPN1; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]