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    PNP-A plant natriuretic peptide A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816381, updated on 7-Sep-2023

    Summary

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    Gene symbol
    PNP-A
    Gene description
    plant natriuretic peptide A
    Primary source
    Araport:AT2G18660
    Locus tag
    AT2G18660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtPNP-A; EXLB3; EXPANSIN-LIKE B3 PRECURSOR; MSF3.4; MSF3_4; plant natriuretic peptide A
    Summary
    Encodes PNP-A (Plant Natriuretic Peptide A). PNPs are a class of systemically mobile molecules distantly related to expansins; their biological role has remained elusive. PNP-A contains a signal peptide domain and is secreted into the extracellular space. Co-expression analyses using microarray data suggest that PNP-A may function as a component of plant defence response and SAR in particular, and could be classified as a newly identified PR protein. It is stress responsive and can enhance its own expression.
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    3
    Sequence:
    Chromosome: 2; NC_003071.7 (8089411..8091736, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene geranylgeranyl pyrophosphate synthase 4 Neighboring gene RING/U-box superfamily protein Neighboring gene RING/U-box superfamily protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis thaliana natriuretic peptide AtPNP-A is a systemic regulator of leaf dark respiration and signals via the phloem. Ruzvidzo O, et al. J Plant Physiol, 2011 Sep 15. PMID 21550130
    2. Plant natriuretic peptides are apoplastic and paracrine stress response molecules. Wang YH, et al. Plant Cell Physiol, 2011 May. PMID 21478192
    3. PLANT NATRIURETIC PEPTIDE A and Its Putative Receptor PNP-R2 Antagonize Salicylic Acid-Mediated Signaling and Cell Death. Lee KP, et al. Plant Cell, 2020 Jul. PMID 32409317, Free PMC Article
    4. The plant natriuretic peptide receptor is a guanylyl cyclase and enables cGMP-dependent signaling. Turek I, et al. Plant Mol Biol, 2016 Jun. PMID 26945740
    5. Contrasting Roles of the Apoplastic Aspartyl Protease APOPLASTIC, ENHANCED DISEASE SUSCEPTIBILITY1-DEPENDENT1 and LEGUME LECTIN-LIKE PROTEIN1 in Arabidopsis Systemic Acquired Resistance. Breitenbach HH, et al. Plant Physiol, 2014 Jun. PMID 24755512, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PLANT NATRIURETIC PEPTIDE A and Its Putative Receptor PNP-R2 Antagonize Salicylic Acid-Mediated Signaling and Cell Death.
      Title: PLANT NATRIURETIC PEPTIDE A and Its Putative Receptor PNP-R2 Antagonize Salicylic Acid-Mediated Signaling and Cell Death.
    2. Locally applied AtPNP-A can induce a phloem-mobile signal that rapidly modifies plant homeostasis in distal parts.
      Title: The Arabidopsis thaliana natriuretic peptide AtPNP-A is a systemic regulator of leaf dark respiration and signals via the phloem.
    3. AtPNP-A, together with abscissic acid, is an important component in complex plant stress responses
      Title: Plant natriuretic peptides are apoplastic and paracrine stress response molecules.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_179648.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables peptide hormone receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within alternative respiration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within systemic acquired resistance IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type cell wall HDA PubMed 

    General protein information

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    Preferred Names
    plant natriuretic peptide A
    NP_849979.1
    • plant natriuretic peptide A (PNP-A); LOCATED IN: extracellular region, cell wall; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Barwin-related endoglucanase (InterPro:IPR009009), Pollen allergen, N-terminal (InterPro:IPR014734), Rare lipoprotein A (InterPro:IPR005132), Expansin 45, endoglucanase-like (InterPro:IPR007112); BEST Arabidopsis thaliana protein match is: Barwin-related endoglucanase (TAIR:AT4G30380.1); Has 232 Blast hits to 231 proteins in 52 species: Archae - 0; Bacteria - 11; Metazoa - 0; Fungi - 6; Plants - 214; Viruses - 0; Other Eukaryotes - 1 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      8089411..8091736 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179648.2 → NP_849979.1  plant natriuretic peptide A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849979.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZV52
      UniProtKB/TrEMBL
      A0A178VYJ1, A0A654ETZ3
      Conserved Domains (1) summary
      cd22269
      Location:26 → 129
      DPBB_EG45-like; double-psi beta-barrel fold of EG45-like domain-containing proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZV52.2

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