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    TYK2 tyrosine kinase 2 [ Homo sapiens (human) ]

    Gene ID: 7297, updated on 3-May-2024

    Summary

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    Official Symbol
    TYK2provided by HGNC
    Official Full Name
    tyrosine kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:12440
    See related
    Ensembl:ENSG00000105397 MIM:176941; AllianceGenome:HGNC:12440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JTK1; IMD35
    Summary
    This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35. [provided by RefSeq, Sep 2020]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Ubiquitous expression in spleen (RPKM 21.6), bone marrow (RPKM 20.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    19p13.2
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10350533..10380572, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (10476657..10506988, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10461209..10491248, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr19:10427579-10427770 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:10430834-10431047 Neighboring gene ribonucleoprotein, PTB binding 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10442682-10443598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10443599-10444515 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10445230-10445848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10448906-10449654 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13959 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10450403-10451150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13960 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10451151-10451898 Neighboring gene intercellular adhesion molecule 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10463923-10464686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10474734-10475234 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10491214-10491877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13962 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13963 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10499431-10499931 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10066 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13965 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10067 Neighboring gene cell division cycle 37, HSP90 cochaperone Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13966 Neighboring gene microRNA 1181 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10068 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13967 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10527911-10528462 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10528463-10529013 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10530007-10530886 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10069 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13968 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13969 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10071 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10072 Neighboring gene phosphodiesterase 4A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10542553-10543236 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10543237-10543919 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10546465-10546964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13971 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10075 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10572008-10572732

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TYK2 single-nucleotide variants associated with the severity of COVID-19 disease. Zabihi Rizi F, et al. Arch Virol, 2023 Mar 23. PMID 36959416, Free PMC Article
    2. Tyk2 Targeting in Immune-Mediated Inflammatory Diseases. Rusiñol L, et al. Int J Mol Sci, 2023 Feb 8. PMID 36834806, Free PMC Article
    3. Clinical Implications of Targeting the JAK-STAT Pathway in Psoriatic Disease: Emphasis on the TYK2 Pathway. Loo WJ, et al. J Cutan Med Surg, 2023 Jan-Feb. PMID 36519621
    4. The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α. Chandra V, et al. Nat Commun, 2022 Oct 26. PMID 36289205, Free PMC Article
    5. Association of germline TYK2 variation with lung cancer and non-Hodgkin lymphoma risk. Yarmolinsky J, et al. Int J Cancer, 2022 Dec 15. PMID 35747941, Free PMC Article

    See all (238) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Community analysis of large-scale molecular dynamics simulations elucidated dynamics-driven allostery in tyrosine kinase 2.
      Title: Community analysis of large-scale molecular dynamics simulations elucidated dynamics-driven allostery in tyrosine kinase 2.
    2. Direct and biologically significant interactions of human herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus kinase TYK2.
      Title: Direct and biologically significant interactions of human herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus kinase TYK2.
    3. Tick-borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2.
      Title: Tick-borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2.
    4. The positive feedback loop of MAD2L1/TYK2/STAT3 induces progression in B-cell acute lymphoblastic leukaemia.
      Title: The positive feedback loop of MAD2L1/TYK2/STAT3 induces progression in B-cell acute lymphoblastic leukaemia.
    5. TYK2 single-nucleotide variants associated with the severity of COVID-19 disease.
      Title: TYK2 single-nucleotide variants associated with the severity of COVID-19 disease.
    6. Tyk2 Targeting in Immune-Mediated Inflammatory Diseases.
      Title: Tyk2 Targeting in Immune-Mediated Inflammatory Diseases.
    7. Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19.
      Title: Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19.
    8. Clinical Implications of Targeting the JAK-STAT Pathway in Psoriatic Disease: Emphasis on the TYK2 Pathway.
      Title: Clinical Implications of Targeting the JAK-STAT Pathway in Psoriatic Disease: Emphasis on the TYK2 Pathway.
    9. The type 1 diabetes gene TYK2 regulates beta-cell development and its responses to interferon-alpha.
      Title: The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α.
    10. Association of germline TYK2 variation with lung cancer and non-Hodgkin lymphoma risk.
      Title: Association of germline TYK2 variation with lung cancer and non-Hodgkin lymphoma risk.
    Submit: New GeneRIF Correction See all GeneRIFs (111)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Immunodeficiency 35
    MedGen: C1969086 OMIM: 611521 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
    EBI GWAS Catalog
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    EBI GWAS Catalog
    Genetics of rheumatoid arthritis contributes to biology and drug discovery.
    EBI GWAS Catalog
    Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
    EBI GWAS Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables growth hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth hormone receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine kinase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables type 1 angiotensin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular response to virus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in growth hormone receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in interleukin-10-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in interleukin-12-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of NK T cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of NK T cell proliferation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of T-helper 17 type immune response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of interleukin-17 production NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of natural killer cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of type II interferon production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in type I interferon-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in type I interferon-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in type I interferon-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in type II interferon-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in type III interferon-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic side of plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    is_active_in extrinsic component of cytoplasmic side of plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in extrinsic component of plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of interleukin-12 receptor complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of interleukin-23 receptor complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    non-receptor tyrosine-protein kinase TYK2
    NP_001372126.1
    NP_001372127.1
    NP_001372128.1
    NP_001372129.1
    NP_001372130.1
    NP_001372131.1
    NP_001372132.1
    NP_001372133.1
    NP_001372134.1
    NP_001372135.1
    NP_001372136.1
    NP_001393390.1
    NP_003322.3
    XP_011526548.1
    XP_011526549.1
    XP_011526551.1
    XP_047295260.1
    XP_047295261.1
    XP_047295262.1
    XP_047295263.1
    XP_054177893.1
    XP_054177894.1
    XP_054177895.1
    XP_054177896.1
    XP_054177897.1
    XP_054177898.1
    XP_054177899.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007872.1 RefSeqGene

      Range
      5001..35045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_121

    mRNA and Protein(s)

    1. NM_001385197.1 → NP_001372126.1  non-receptor tyrosine-protein kinase TYK2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC011557
      Consensus CDS
      CCDS92513.1
      UniProtKB/TrEMBL
      A0A8E7DA23, H0YE24
      Related
      ENSP00000434831.2, ENST00000525976.6
      Conserved Domains (6) summary
      cd05076
      Location:589 → 867
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam17887
      Location:285 → 432
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:143 → 266
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:28 → 125
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:437 → 534
      SH2; Src homology 2 (SH2) domain
      cl21453
      Location:892 → 1137
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001385198.1 → NP_001372127.1  non-receptor tyrosine-protein kinase TYK2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC011557
      UniProtKB/TrEMBL
      A0A8V8TPJ0
      Conserved Domains (6) summary
      cd05076
      Location:589 → 867
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam17887
      Location:285 → 432
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:143 → 266
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:28 → 125
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:437 → 534
      SH2; Src homology 2 (SH2) domain
      cl21453
      Location:892 → 1124
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001385199.1 → NP_001372128.1  non-receptor tyrosine-protein kinase TYK2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC011557
      UniProtKB/TrEMBL
      A0A8E7DA23
      Conserved Domains (6) summary
      cd05080
      Location:830 → 1112
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam17887
      Location:285 → 432
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:143 → 266
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:28 → 125
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:437 → 534
      SH2; Src homology 2 (SH2) domain
      cl21453
      Location:586 → 805
      PKc_like; Protein Kinases, catalytic domain

    4. NM_001385200.1 → NP_001372129.1  non-receptor tyrosine-protein kinase TYK2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC011557
      UniProtKB/TrEMBL
      A0A8E7DA23
      Conserved Domains (6) summary
      cd05076
      Location:589 → 866
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:891 → 1173
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam17887
      Location:285 → 432
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:143 → 266
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:28 → 125
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:437 → 534
      SH2; Src homology 2 (SH2) domain

    5. NM_001385201.1 → NP_001372130.1  non-receptor tyrosine-protein kinase TYK2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC011557
      UniProtKB/TrEMBL
      A0A8E7DA23
      Conserved Domains (6) summary
      cd05076
      Location:523 → 801
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:826 → 1108
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam18377
      Location:143 → 266
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:28 → 125
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:371 → 468
      SH2; Src homology 2 (SH2) domain
      cl17171
      Location:270 → 371
      PH-like; Pleckstrin homology-like domain

    6. NM_001385202.1 → NP_001372131.1  non-receptor tyrosine-protein kinase TYK2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC011557
      UniProtKB/TrEMBL
      A0A8E7DA23
      Conserved Domains (6) summary
      cd05080
      Location:864 → 1146
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam17887
      Location:285 → 432
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:143 → 266
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:28 → 125
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:437 → 534
      SH2; Src homology 2 (SH2) domain
      cl21453
      Location:589 → 839
      PKc_like; Protein Kinases, catalytic domain

    7. NM_001385203.1 → NP_001372132.1  non-receptor tyrosine-protein kinase TYK2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC011557
      UniProtKB/TrEMBL
      A0A8E7DA23
      Conserved Domains (6) summary
      cd05076
      Location:589 → 867
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:919 → 1201
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam17887
      Location:285 → 432
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:143 → 266
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:28 → 125
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:437 → 534
      SH2; Src homology 2 (SH2) domain

    8. NM_001385204.1 → NP_001372133.1  non-receptor tyrosine-protein kinase TYK2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC011557
      UniProtKB/TrEMBL
      A0A8E7DA23
      Related
      ENST00000529370.6
      Conserved Domains (6) summary
      cd05080
      Location:962 → 1244
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam17887
      Location:285 → 432
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:143 → 266
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:28 → 125
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:437 → 534
      SH2; Src homology 2 (SH2) domain
      cl21453
      Location:589 → 937
      PKc_like; Protein Kinases, catalytic domain

    9. NM_001385205.1 → NP_001372134.1  non-receptor tyrosine-protein kinase TYK2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC011557
      UniProtKB/TrEMBL
      A0A8E7DA23
      Conserved Domains (6) summary
      cd05076
      Location:559 → 837
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:862 → 1144
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam17887
      Location:255 → 402
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:143 → 236
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:28 → 125
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:407 → 504
      SH2; Src homology 2 (SH2) domain

    10. NM_001385206.1 → NP_001372135.1  non-receptor tyrosine-protein kinase TYK2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC011557
      UniProtKB/TrEMBL
      A0A8E7DA23
      Conserved Domains (6) summary
      cd05076
      Location:547 → 825
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:850 → 1132
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam17887
      Location:285 → 432
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:143 → 266
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:28 → 125
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:437 → 490
      SH2; Src homology 2 (SH2) domain

    11. NM_001385207.1 → NP_001372136.1  non-receptor tyrosine-protein kinase TYK2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC011557
      UniProtKB/TrEMBL
      A0A8E7DA23
      Conserved Domains (6) summary
      cd05080
      Location:886 → 1168
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam17887
      Location:285 → 432
      Jak1_Phl; Jak1 pleckstrin homology-like domain
      pfam18377
      Location:143 → 266
      FERM_F2; FERM F2 acyl-CoA binding protein-like domain
      pfam18379
      Location:28 → 125
      FERM_F1; FERM F1 ubiquitin-like domain
      cl15255
      Location:437 → 534
      SH2; Src homology 2 (SH2) domain
      cl21453
      Location:584 → 861
      PKc_like; Protein Kinases, catalytic domain

    12. NM_001406461.1 → NP_001393390.1  non-receptor tyrosine-protein kinase TYK2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC011557
      Consensus CDS
      CCDS12236.1
      UniProtKB/Swiss-Prot
      P29597, Q6QB10, Q96CH0
      Related
      ENSP00000436175.2, ENST00000531836.6

    13. NM_003331.5 → NP_003322.3  non-receptor tyrosine-protein kinase TYK2 isoform 2

      See identical proteins and their annotated locations for NP_003322.3

      Status: REVIEWED

      Source sequence(s)
      AK308360, BC014243, DA864169
      Consensus CDS
      CCDS12236.1
      UniProtKB/Swiss-Prot
      P29597, Q6QB10, Q96CH0
      UniProtKB/TrEMBL
      A0A8E7DA23
      Related
      ENSP00000431885.1, ENST00000525621.6
      Conserved Domains (7) summary
      smart00219
      Location:897 → 1169
      TyrKc; Tyrosine kinase, catalytic domain
      smart00295
      Location:28 → 273
      B41; Band 4.1 homologues
      cd05076
      Location:589 → 867
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:892 → 1174
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam07714
      Location:589 → 866
      Pkinase_Tyr; Protein tyrosine kinase
      cl15255
      Location:437 → 534
      SH2; Src homology 2 (SH2) domain
      cl17171
      Location:270 → 437
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      10350533..10380572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528246.4 → XP_011526548.1  non-receptor tyrosine-protein kinase TYK2 isoform X2

      See identical proteins and their annotated locations for XP_011526548.1

      UniProtKB/TrEMBL
      E9PM19
      Conserved Domains (7) summary
      smart00219
      Location:798 → 1070
      TyrKc; Tyrosine kinase, catalytic domain
      smart00295
      Location:2 → 174
      B41; Band 4.1 homologues
      cd05076
      Location:490 → 768
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:793 → 1075
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam07714
      Location:490 → 767
      Pkinase_Tyr; Protein tyrosine kinase
      cl15255
      Location:338 → 435
      SH2; Src homology 2 (SH2) domain
      cl17171
      Location:171 → 338
      PH-like; Pleckstrin homology-like domain

    2. XM_011528247.2 → XP_011526549.1  non-receptor tyrosine-protein kinase TYK2 isoform X2

      See identical proteins and their annotated locations for XP_011526549.1

      UniProtKB/TrEMBL
      E9PM19
      Related
      ENSP00000433203.1, ENST00000524462.5
      Conserved Domains (7) summary
      smart00219
      Location:798 → 1070
      TyrKc; Tyrosine kinase, catalytic domain
      smart00295
      Location:2 → 174
      B41; Band 4.1 homologues
      cd05076
      Location:490 → 768
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:793 → 1075
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam07714
      Location:490 → 767
      Pkinase_Tyr; Protein tyrosine kinase
      cl15255
      Location:338 → 435
      SH2; Src homology 2 (SH2) domain
      cl17171
      Location:171 → 338
      PH-like; Pleckstrin homology-like domain

    3. XM_011528249.3 → XP_011526551.1  non-receptor tyrosine-protein kinase TYK2 isoform X4

      Conserved Domains (5) summary
      smart00219
      Location:455 → 727
      TyrKc; Tyrosine kinase, catalytic domain
      cd05076
      Location:147 → 425
      PTK_Tyk2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      cd05080
      Location:450 → 732
      PTKc_Tyk2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2
      pfam07714
      Location:147 → 424
      Pkinase_Tyr; Protein tyrosine kinase
      cl15255
      Location:15 → 92
      SH2; Src homology 2 (SH2) domain

    4. XM_047439304.1 → XP_047295260.1  non-receptor tyrosine-protein kinase TYK2 isoform X1

    5. XM_047439305.1 → XP_047295261.1  non-receptor tyrosine-protein kinase TYK2 isoform X3

      UniProtKB/TrEMBL
      A0A8V8TN50
      Related
      ENSP00000514329.1, ENST00000699358.1

    6. XM_047439306.1 → XP_047295262.1  non-receptor tyrosine-protein kinase TYK2 isoform X5

      UniProtKB/TrEMBL
      H0YCT7
      Related
      ENSP00000432320.2, ENST00000533334.2

    7. XM_047439307.1 → XP_047295263.1  non-receptor tyrosine-protein kinase TYK2 isoform X6

      UniProtKB/TrEMBL
      A0A8V8TPX5
      Related
      ENSP00000514328.1, ENST00000699355.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      10476657..10506988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321919.1 → XP_054177894.1  non-receptor tyrosine-protein kinase TYK2 isoform X2

    2. XM_054321920.1 → XP_054177895.1  non-receptor tyrosine-protein kinase TYK2 isoform X2

    3. XM_054321922.1 → XP_054177897.1  non-receptor tyrosine-protein kinase TYK2 isoform X4

    4. XM_054321918.1 → XP_054177893.1  non-receptor tyrosine-protein kinase TYK2 isoform X1

    5. XM_054321921.1 → XP_054177896.1  non-receptor tyrosine-protein kinase TYK2 isoform X3

    6. XM_054321923.1 → XP_054177898.1  non-receptor tyrosine-protein kinase TYK2 isoform X5

    7. XM_054321924.1 → XP_054177899.1  non-receptor tyrosine-protein kinase TYK2 isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29597.3 GenPept UniProtKB/Swiss-Prot:P29597

    Gene LinkOut

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