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    BRPF3 bromodomain and PHD finger containing 3 [ Homo sapiens (human) ]

    Gene ID: 27154, updated on 3-Apr-2024

    Summary

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    Official Symbol
    BRPF3provided by HGNC
    Official Full Name
    bromodomain and PHD finger containing 3provided by HGNC
    Primary source
    HGNC:HGNC:14256
    See related
    Ensembl:ENSG00000096070 MIM:616856; AllianceGenome:HGNC:14256
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable histone binding activity. Involved in histone H3-K14 acetylation and positive regulation of DNA replication. Part of MOZ/MORF histone acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 15.9), kidney (RPKM 10.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    6p21.31
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (36196744..36232790)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (36017037..36053081)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (36164521..36200567)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 14 Neighboring gene NUDT5 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24418 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17107 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:36098441-36099044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36106471-36106971 Neighboring gene mitogen-activated protein kinase 13 Neighboring gene BRPF3 antisense RNA 1 Neighboring gene MPRA-validated peak5782 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36203227-36203772 Neighboring gene Sharpr-MPRA regulatory region 10771 Neighboring gene uncharacterized LOC105375036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36235945-36236531 Neighboring gene patatin like phospholipase domain containing 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:36253718-36253903 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36269917-36270417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24423 Neighboring gene BCL2 interacting protein 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation. Feng Y, et al. EMBO J, 2016 Jan 18. PMID 26620551, Free PMC Article
    2. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. Ullah M, et al. Mol Cell Biol, 2008 Nov. PMID 18794358, Free PMC Article
    3. KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation. Ohzeki J, et al. Dev Cell, 2016 Jun 6. PMID 27270040, Free PMC Article
    4. Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa. Gogstad GO, et al. Biochim Biophys Acta, 1981 Sep 29. PMID 6457647
    5. Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Coppinger JA, et al. Blood, 2004 Mar 15. PMID 14630798

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to histone H3K14 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to histone H4K12 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to histone H4K5 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to histone H4K8 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of developmental process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of hemopoiesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MOZ/MORF histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MOZ/MORF histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of MOZ/MORF histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    part_of histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    bromodomain and PHD finger-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015695.3 → NP_056510.2  bromodomain and PHD finger-containing protein 3

      See identical proteins and their annotated locations for NP_056510.2

      Status: VALIDATED

      Source sequence(s)
      AB033112, BC039615, Z84485
      Consensus CDS
      CCDS34437.1
      UniProtKB/Swiss-Prot
      A6ND56, A6NJE2, B7ZLN5, E7EX85, Q17RB6, Q5R3K8, Q9ULD4
      UniProtKB/TrEMBL
      E9PI60
      Related
      ENSP00000350267.6, ENST00000357641.10
      Conserved Domains (6) summary
      cd05839
      Location:1074 → 1189
      BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
      cd05512
      Location:593 → 690
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15572
      Location:212 → 265
      PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
      cd15703
      Location:269 → 386
      ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
      pfam10513
      Location:48 → 194
      EPL1; Enhancer of polycomb-like
      pfam15429
      Location:848 → 972
      DUF4628; Domain of unknown function (DUF4628)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      36196744..36232790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514490.2 → XP_011512792.1  bromodomain and PHD finger-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      E9PI60
      Conserved Domains (6) summary
      cd05512
      Location:593 → 690
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15572
      Location:212 → 265
      PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
      cd15703
      Location:269 → 386
      ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
      pfam10513
      Location:48 → 194
      EPL1; Enhancer of polycomb-like
      pfam15429
      Location:848 → 972
      DUF4628; Domain of unknown function (DUF4628)
      cl02554
      Location:1074 → 1144
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    2. XM_047418649.1 → XP_047274605.1  bromodomain and PHD finger-containing protein 3 isoform X6

      UniProtKB/Swiss-Prot
      A6ND56, A6NJE2, B7ZLN5, E7EX85, Q17RB6, Q5R3K8, Q9ULD4
      Related
      ENSP00000436504.1, ENST00000534400.5

    3. XM_011514491.2 → XP_011512793.1  bromodomain and PHD finger-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      E9PI60
      Conserved Domains (7) summary
      cd05512
      Location:593 → 690
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      COG5076
      Location:528 → 743
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      cd15572
      Location:212 → 265
      PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
      cd15703
      Location:269 → 386
      ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
      pfam10513
      Location:48 → 194
      EPL1; Enhancer of polycomb-like
      pfam15429
      Location:848 → 972
      DUF4628; Domain of unknown function (DUF4628)
      cl02554
      Location:1074 → 1095
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    4. XM_047418650.1 → XP_047274606.1  bromodomain and PHD finger-containing protein 3 isoform X3

    5. XM_011514492.2 → XP_011512794.1  bromodomain and PHD finger-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      E9PSF3
      Conserved Domains (4) summary
      cd05512
      Location:593 → 690
      Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
      cd15572
      Location:212 → 265
      PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
      cd15703
      Location:269 → 386
      ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
      pfam10513
      Location:48 → 194
      EPL1; Enhancer of polycomb-like

    6. XM_047418651.1 → XP_047274607.1  bromodomain and PHD finger-containing protein 3 isoform X5

      UniProtKB/TrEMBL
      F6XDC4
      Related
      ENSP00000437087.1, ENST00000532330.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      36017037..36053081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355175.1 → XP_054211150.1  bromodomain and PHD finger-containing protein 3 isoform X7

    2. XM_054355176.1 → XP_054211151.1  bromodomain and PHD finger-containing protein 3 isoform X1

    3. XM_054355177.1 → XP_054211152.1  bromodomain and PHD finger-containing protein 3 isoform X2

    4. XM_054355178.1 → XP_054211153.1  bromodomain and PHD finger-containing protein 3 isoform X3

    5. XM_054355179.1 → XP_054211154.1  bromodomain and PHD finger-containing protein 3 isoform X4

    6. XM_054355180.1 → XP_054211155.1  bromodomain and PHD finger-containing protein 3 isoform X5

      UniProtKB/TrEMBL
      F6XDC4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ULD4.2 GenPept UniProtKB/Swiss-Prot:Q9ULD4

    Gene LinkOut

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