BRMS1 BRMS1 transcriptional repressor and anoikis regulator [Homo sapiens (human)] - Gene

Summary

Official Symbol: BRMS1provided by HGNC
Official Full Name: BRMS1 transcriptional repressor and anoikis regulatorprovided by HGNC
Primary source: HGNC:HGNC:17262
See related: Ensembl:ENSG00000174744 MIM:606259; AllianceGenome:HGNC:17262
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in bone marrow (RPKM 18.9), testis (RPKM 16.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q13.2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (66337339..66345104, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (66330994..66338767, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (66104810..66112575, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Distinct expression and function of breast cancer metastasis suppressor 1 in mutant P53 glioblastoma.
Title: Distinct expression and function of breast cancer metastasis suppressor 1 in mutant P53 glioblastoma.
A germline SNP in BRMS1 predisposes patients with lung adenocarcinoma to metastasis and can be ameliorated by targeting c-fos.
Title: A germline SNP in BRMS1 predisposes patients with lung adenocarcinoma to metastasis and can be ameliorated by targeting c-fos.
N6-Methyladenosine modification of the TRIM7 positively regulates tumorigenesis and chemoresistance in osteosarcoma through ubiquitination of BRMS1.
Title: N6-Methyladenosine modification of the TRIM7 positively regulates tumorigenesis and chemoresistance in osteosarcoma through ubiquitination of BRMS1.
suggest that BRMS! NLS2 is a disordered region, with non pre-formed structure, that participates in metastasis suppression
Title: The isolated C-terminal nuclear localization sequence of the breast cancer metastasis suppressor 1 is disordered.
BRMS1 gene expression and anti-metastatic role in the breast cancer.
Title: Additive effect of metastamiR-193b and breast cancer metastasis suppressor 1 as an anti-metastatic strategy.
BRMS1FANCI interaction is necessary for the regulatory role of BRMS1 in the FA pathway.
Title: BRMS1 participates in regulating cell sensitivity to DNA interstrand crosslink damage by interacting with FANCI.
overexpression of miR-3200-5p significantly decreased BRMS1 levels and promoted OS cell invasion and migration, while depletion of miR-3200-5p significantly increased BRMS1 levels and inhibited OS cell invasion and migration. Study revealed that miR-3200-5p may be a critical regulator of OS cell invasiveness.
Title: MicroRNA-3200-5p Promotes Osteosarcoma Cell Invasion via Suppression of BRMS1.
Low BRMS1 expression is associated with Hepatocellular carcinoma.
Title: miR-346 Promotes HCC Progression by Suppressing Breast Cancer Metastasis Suppressor 1 Expression.
Low BRMS1 expression is associated with high metastatic capacity of breast cancer.
Title: Breast cancer metastasis suppressor gene, breast cancer metastasis suppressor 1, may be associated with clinicopathological features of breast cancer.
High BRMS1 Expression is associated with Metastases and recurrence in Lung Adenocarcinoma.
Title: BRMS1 Expression in Surgically Resected Lung Adenocarcinoma Predicts Future Metastases and Is Associated with a Poor Prognosis.

Submit: New GeneRIF Correction See all GeneRIFs (77)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-W44699 (e-PCR)
- UniSTS:81113

WI-20154 (e-PCR)
- UniSTS:8169

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables NF-kappaB binding	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell migration	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of stem cell population maintenance	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of anoikis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein deacetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of stem cell population maintenance	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of Sin3-type complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Sin3-type complex	NAS Non-traceable Author Statement more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: breast cancer metastasis-suppressor 1

Names: breast cancer metastasis suppressor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024957.2 → NP_001020128.1 breast cancer metastasis-suppressor 1 isoform 2

See identical proteins and their annotated locations for NP_001020128.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon which results in the use of a downstream stop codon, compared to variant 1. The encoded protein (isoform 2) has a longer and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AP001107, BM312965, CB130346, CB529276

Consensus CDS

CCDS44654.1

UniProtKB/TrEMBL

E9PJF5, G5E9I4

Related

ENSP00000396052.2, ENST00000425825.6

Conserved Domains (1) summary

pfam08598
Location:60 → 177

Sds3; Sds3-like
NM_015399.4 → NP_056214.1 breast cancer metastasis-suppressor 1 isoform 1

See identical proteins and their annotated locations for NP_056214.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest and more abundant transcript and encodes isoform (1).

Source sequence(s)

AP001107, BU734281, CB130346

Consensus CDS

CCDS8135.1

UniProtKB/Swiss-Prot

Q6IAI2, Q9HCU9

UniProtKB/TrEMBL

E9PJF5

Related

ENSP00000353042.3, ENST00000359957.8

Conserved Domains (1) summary

pfam08598
Location:60 → 178

Sds3; Sds3-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

66337339..66345104 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024448426.2 → XP_024304194.1 breast cancer metastasis-suppressor 1 isoform X2

UniProtKB/TrEMBL

E9PJF5

Conserved Domains (1) summary

pfam08598
Location:60 → 178

Sds3; Sds3-like
XM_024448425.2 → XP_024304193.1 breast cancer metastasis-suppressor 1 isoform X1

UniProtKB/TrEMBL

H0YCF7

Related

ENSP00000431510.1, ENST00000524699.5

Conserved Domains (1) summary

pfam08598
Location:60 → 178

Sds3; Sds3-like

Alternate T2T-CHM13v2.0

Genomic

NC_060935.1 Alternate T2T-CHM13v2.0

Range

66330994..66338767 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054368347.1 → XP_054224322.1 breast cancer metastasis-suppressor 1 isoform X2
XM_054368346.1 → XP_054224321.1 breast cancer metastasis-suppressor 1 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001024958.1: Suppressed sequence

Description

NM_001024958.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.