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    cox-2 cyclooxygenase-2 [ Oncorhynchus mykiss (rainbow trout) ]

    Gene ID: 100136025, updated on 14-Dec-2023

    Summary

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    Gene symbol
    cox-2
    Gene description
    cyclooxygenase-2
    See related
    Ensembl:ENSOMYG00000005747
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Oncorhynchus mykiss
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes; Salmonidae; Salmoninae; Oncorhynchus
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    Genomic context

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    Location:
    chromosome: 8
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    101 current USDA_OmykA_1.1 (GCF_013265735.2) 8 NC_048572.1 (55479560..55484248)
    100 previous assembly Omyk_1.0 (GCF_002163495.1) 8 NC_035084.1 (50818311..50822994)

    Chromosome 8 - NC_048572.1Genomic Context describing neighboring genes Neighboring gene probable serine/threonine-protein kinase MARK-A Neighboring gene actin-related protein 2/3 complex subunit 5 Neighboring gene phosducin-like Neighboring gene odr-4 GPCR localization factor homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables prostaglandin-endoperoxide synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cyclooxygenase pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclooxygenase-2
    NP_001117820.1
    XP_021466892.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001124348.1 → NP_001117820.1  cyclooxygenase-2 precursor

      See identical proteins and their annotated locations for NP_001117820.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ238307
      UniProtKB/TrEMBL
      A0A060WQB0, Q9W715
      Related
      ENSOMYP00000011725.1, ENSOMYT00000012982.2
      Conserved Domains (2) summary
      cd09816
      Location:78 → 566
      prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
      cd00054
      Location:21 → 58
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    RefSeqs of Annotated Genomes: Oncorhynchus mykiss Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference USDA_OmykA_1.1 Primary Assembly

    Genomic

    1. NC_048572.1 Reference USDA_OmykA_1.1 Primary Assembly

      Range
      55479560..55484248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021611217.2 → XP_021466892.1  cyclooxygenase-2 isoform X1

      UniProtKB/TrEMBL
      A0A8C7NRG0
      Related
      ENSOMYP00000011560.1, ENSOMYT00000012808.2
      Conserved Domains (2) summary
      cd09816
      Location:83 → 571
      prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
      cd00054
      Location:26 → 63
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    Nucleotide Protein
    Heading Accession and Version

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    Molecular Biology Databases