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    ced-6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35971, updated on 26-Apr-2024

    Summary

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    Official Symbol
    ced-6provided by FlyBase
    Primary source
    FLYBASE:FBgn0029092
    Locus tag
    Dmel_CG11804
    See related
    AllianceGenome:FB:FBgn0029092
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Ced-6; CED-6; ced6; CG11804; dced-6; dCed-6; dCED-6; dced6; Dmel\CG11804; drced-6; drCed-6; drCed6
    Summary
    Involved in apoptotic cell clearance; mushroom body development; and neuron remodeling. Is expressed in several structures, including adult head; brain; embryonic/larval garland cell; and neuropil. Orthologous to human GULP1 (GULP PTB domain containing engulfment adaptor 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    45D7-45D8; 2-60 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9434669..9444937, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5322174..5332442, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene preli-like Neighboring gene Pyruvate dehydrogenase kinase Neighboring gene long non-coding RNA:CR45321 Neighboring gene Calmodulin-binding transcription activator Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TU-tagging: cell type-specific RNA isolation from intact complex tissues. Miller MR, et al. Nat Methods, 2009 Jun. PMID 19430475, Free PMC Article
    2. Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy. Ziegenfuss JS, et al. Nat Neurosci, 2012 Jun 17. PMID 22706267, Free PMC Article
    3. Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury. Logan MA, et al. Nat Neurosci, 2012 Mar 18. PMID 22426252, Free PMC Article
    4. Glia and muscle sculpt neuromuscular arbors by engulfing destabilized synaptic boutons and shed presynaptic debris. Fuentes-Medel Y, et al. PLoS Biol, 2009 Aug. PMID 19707574, Free PMC Article
    5. Ensheathing glia function as phagocytes in the adult Drosophila brain. Doherty J, et al. J Neurosci, 2009 Apr 15. PMID 19369546, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ced-6 is essential for axon pruning and the removal of living neurons during development.
      Title: Essential role of the apoptotic cell engulfment genes draper and ced-6 in programmed axon pruning during Drosophila metamorphosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mushroom body development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ced-6
    Names
    CG11804-PA
    CG11804-PB
    CG11804-PC
    CG11804-PD
    CG11804-PF
    ced-6-PA
    ced-6-PB
    ced-6-PC
    ced-6-PD
    ced-6-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9434669..9444937 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259296.2 → NP_001246225.1  ced-6, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246225.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E0R983
      Conserved Domains (2) summary
      cd01273
      Location:92 → 261
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      cl01891
      Location:233 → 304
      AceK; Isocitrate dehydrogenase kinase/phosphatase (AceK)

    2. NM_136644.3 → NP_610488.1  ced-6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610488.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JUY7
      UniProtKB/TrEMBL
      E2QC90
      Related
      FBpp0087632
      Conserved Domains (2) summary
      cd01273
      Location:76 → 245
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      cl01891
      Location:217 → 288
      AceK; Isocitrate dehydrogenase kinase/phosphatase (AceK)

    3. NM_001259297.2 → NP_001246226.2  ced-6, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246226.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K730
      Conserved Domains (2) summary
      cd01273
      Location:76 → 245
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      cl01891
      Location:217 → 288
      AceK; Isocitrate dehydrogenase kinase/phosphatase (AceK)

    4. NM_165676.2 → NP_724790.1  ced-6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724790.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JUY7
      UniProtKB/TrEMBL
      E2QC90
      Related
      FBpp0087631
      Conserved Domains (2) summary
      cd01273
      Location:76 → 245
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      cl01891
      Location:217 → 288
      AceK; Isocitrate dehydrogenase kinase/phosphatase (AceK)

    5. NM_165675.3 → NP_724789.1  ced-6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724789.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JUY7
      UniProtKB/TrEMBL
      E2QC90
      Related
      FBpp0087633
      Conserved Domains (2) summary
      cd01273
      Location:76 → 245
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      cl01891
      Location:217 → 288
      AceK; Isocitrate dehydrogenase kinase/phosphatase (AceK)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K730 A0A0B4K730
    E0R983 E0R983
    E2QC90 E2QC90
    Q7JUY7.1 Q7JUY7

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