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    LOC100595735 alpha-2-macroglobulin [ Nomascus leucogenys (northern white-cheeked gibbon) ]

    Gene ID: 100595735, updated on 9-Nov-2023

    Summary

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    Gene symbol
    LOC100595735
    Gene description
    alpha-2-macroglobulin
    See related
    EnsemblRapid:ENSNLEG00000002368
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Nomascus leucogenys
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae; Nomascus
    Also known as
    A2M
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    Genomic context

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    Location:
    chromosome: 23
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    103 current Asia_NLE_v1 (GCF_006542625.1) 23 NC_044403.1 (24137591..24186451)
    102 previous assembly Nleu_3.0 (GCF_000146795.2) 23 NC_019838.1 (25915577..25973276)

    Chromosome 23 - NC_044403.1Genomic Context describing neighboring genes Neighboring gene PZP alpha-2-macroglobulin like Neighboring gene translationally-controlled tumor protein-like Neighboring gene protein BTG1 pseudogene Neighboring gene uncharacterized LOC115832920 Neighboring gene putative uncharacterized protein encoded by LINC00612 Neighboring gene voltage-dependent anion-selective channel protein 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-2-macroglobulin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Nomascus leucogenys Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Asia_NLE_v1 Primary Assembly

    Genomic

    1. NC_044403.1 Reference Asia_NLE_v1 Primary Assembly

      Range
      24137591..24186451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003265451.4 → XP_003265499.2  alpha-2-macroglobulin isoform X2

      UniProtKB/TrEMBL
      A0A2I3H3D5
      Related
      ENSNLEP00000003192.3, ENSNLET00000003352.4
      Conserved Domains (7) summary
      cd02897
      Location:958 → 1264
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:738 → 828
      A2M; Alpha-2-macroglobulin family
      pfam07677
      Location:1376 → 1463
      A2M_recep; A-macroglobulin receptor
      pfam17789
      Location:350 → 445
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:223 → 310
      MG3; Macroglobulin domain MG3
      pfam01835
      Location:129 → 221
      A2M_N; MG2 domain
      pfam07703
      Location:459 → 607
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    2. XM_012502382.2 → XP_012357836.2  alpha-2-macroglobulin isoform X4

      UniProtKB/TrEMBL
      A0A2I3H3D5
      Conserved Domains (7) summary
      cd02897
      Location:713 → 1019
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:493 → 583
      A2M; Alpha-2-macroglobulin family
      pfam05326
      Location:545 → 638
      SVA; Seminal vesicle autoantigen (SVA)
      pfam07677
      Location:1131 → 1218
      A2M_recep; A-macroglobulin receptor
      pfam17789
      Location:105 → 200
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:1 → 65
      MG3; Macroglobulin domain MG3
      pfam07703
      Location:214 → 362
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    3. XM_030804754.1 → XP_030660614.1  alpha-2-macroglobulin isoform X1

      UniProtKB/TrEMBL
      A0A2I3H3D5
      Related
      ENSNLEP00000037977.2, ENSNLET00000049090.2
      Conserved Domains (7) summary
      cd02897
      Location:958 → 1264
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:738 → 828
      A2M; Alpha-2-macroglobulin family
      pfam07677
      Location:1376 → 1463
      A2M_recep; A-macroglobulin receptor
      pfam17789
      Location:350 → 445
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:223 → 310
      MG3; Macroglobulin domain MG3
      pfam01835
      Location:129 → 221
      A2M_N; MG2 domain
      pfam07703
      Location:459 → 607
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    4. XM_030804755.1 → XP_030660615.1  alpha-2-macroglobulin isoform X3

      UniProtKB/TrEMBL
      A0A2I3H3D5
      Conserved Domains (7) summary
      cd02897
      Location:713 → 1019
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:493 → 583
      A2M; Alpha-2-macroglobulin family
      pfam05326
      Location:545 → 638
      SVA; Seminal vesicle autoantigen (SVA)
      pfam07677
      Location:1131 → 1218
      A2M_recep; A-macroglobulin receptor
      pfam17789
      Location:105 → 200
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:1 → 65
      MG3; Macroglobulin domain MG3
      pfam07703
      Location:214 → 362
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    Nucleotide Protein
    Heading Accession and Version

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