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    LOS4 P-loop containing nucleoside triphosphate hydrolases superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824477, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LOS4
    Official Full Name
    P-loop containing nucleoside triphosphate hydrolases superfamily protein
    Primary source
    TAIR:AT3G53110
    Locus tag
    AT3G53110
    See related
    Araport:AT3G53110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    LOW EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 4
    Summary
    Encodes a putative DEAD-Box RNA Helicase and has RNA-dependent ATPase activity. Mutant is Sensitive to chilling stress and heat stress. Germination of the mutant is inhibited by ABA. LOS4 may be involved in temperature sensing. Is enriched in the nuclear envelope and also located in the cytoplasm. LOS4 is involved in export of poly A RNA.
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    Genomic context

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    See LOS4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Sequence:
    Chromosome: 3; NC_003074.8 (19687740..19690661)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene D-galactoside/L-rhamnose binding SUEL lectin protein Neighboring gene ubiquitin-protein ligase 7 Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein Neighboring gene Modifier of rudimentary (Mod(r)) protein Neighboring gene Cytochrome P450 superfamily protein Neighboring gene O-methyltransferase family protein Neighboring gene UDP-glucosyl transferase 73D1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A DEAD box RNA helicase is essential for mRNA export and important for development and stress responses in Arabidopsis. Gong Z, et al. Plant Cell, 2005 Jan. PMID 15598798, Free PMC Article
    2. RNA helicase-like protein as an early regulator of transcription factors for plant chilling and freezing tolerance. Gong Z, et al. Proc Natl Acad Sci U S A, 2002 Aug 20. PMID 12165572, Free PMC Article
    3. InsP6-sensitive variants of the Gle1 mRNA export factor rescue growth and fertility defects of the ipk1 low-phytic-acid mutation in Arabidopsis. Lee HS, et al. Plant Cell, 2015 Feb. PMID 25670768, Free PMC Article
    4. LONO1 encoding a nucleoporin is required for embryogenesis and seed viability in Arabidopsis. Braud C, et al. Plant Physiol, 2012 Oct. PMID 22898497, Free PMC Article
    5. Telomerase Interaction Partners-Insight from Plants. Fulnečková J, et al. Int J Mol Sci, 2021 Dec 29. PMID 35008793, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRYOPHYTE/LOS4 RNA helicase plays an important role in mRNA export, plant development, and stress responses. [LOS4]
      Title: A DEAD box RNA helicase is essential for mRNA export and important for development and stress responses in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_115171.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP-dependent activity, acting on RNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within poly(A)+ mRNA export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    P-loop containing nucleoside triphosphate hydrolases superfamily protein
    NP_190879.1
    • LOW EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 4 (LOS4); FUNCTIONS IN: RNA helicase activity, RNA-dependent ATPase activity, ATP-dependent helicase activity; INVOLVED IN: poly(A)+ mRNA export from nucleus, response to cold, response to heat, response to abscisic acid stimulus; LOCATED IN: nuclear envelope, plasma membrane, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: RNA helicase, DEAD-box type, Q motif (InterPro:IPR014014), DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: eukaryotic initiation factor 4A-III (TAIR:AT3G19760.1); Has 40925 Blast hits to 40635 proteins in 3033 species: Archae - 702; Bacteria - 21081; Metazoa - 5720; Fungi - 4311; Plants - 2419; Viruses - 28; Other Eukaryotes - 6664 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      19687740..19690661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115171.3 → NP_190879.1  P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190879.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93ZG7, Q9SCQ0
      UniProtKB/TrEMBL
      A0A178VC43, A0A5S9XKL9
      Conserved Domains (2) summary
      COG0513
      Location:73 → 490
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd17963
      Location:98 → 301
      DEADc_DDX19_DDX25; DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93ZG7.2

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