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    CBS cystathionine beta-synthase [ Bos taurus (cattle) ]

    Gene ID: 514525, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CBSprovided by VGNC
    Official Full Name
    cystathionine beta-synthaseprovided by VGNC
    Primary source
    VGNC:VGNC:108974
    See related
    BGD:BT21351; Ensembl:ENSBTAG00000000160
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (143219507..143242399, complement)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit V3 Neighboring gene uncharacterized LOC132345932 Neighboring gene PBX/knotted 1 homeobox 1 Neighboring gene U2 small nuclear RNA auxiliary factor 1 Neighboring gene crystallin alpha A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence for the evolutionary origin of human chromosome 21 from comparative gene mapping in the cow and mouse. Threadgill DS, et al. Proc Natl Acad Sci U S A, 1991 Jan 1. PMID 1986361, Free PMC Article
    2. Synthesis of Reactive Sulfur Species in Cultured Vascular Endothelial Cells after Exposure to TGF-β(1): Induction of Cystathionine γ-Lyase and Cystathionine β-Synthase Expression Mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 Pathways. Takahashi M, et al. Int J Mol Sci, 2021 Oct 29. PMID 34769192, Free PMC Article
    3. Hepatic Activity and Transcription of Betaine-Homocysteine Methyltransferase, Methionine Synthase, and Cystathionine Synthase in Periparturient Dairy Cows Are Altered to Different Extents by Supply of Methionine and Choline. Zhou Z, et al. J Nutr, 2017 Jan. PMID 27881594
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Synthesis of Reactive Sulfur Species in Cultured Vascular Endothelial Cells after Exposure to TGF-beta1: Induction of Cystathionine gamma-Lyase and Cystathionine beta-Synthase Expression Mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 Pathways.
      Title: Synthesis of Reactive Sulfur Species in Cultured Vascular Endothelial Cells after Exposure to TGF-β(1): Induction of Cystathionine γ-Lyase and Cystathionine β-Synthase Expression Mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 Pathways.
    2. These findings indicate that greater synthesis of phosphatidylcholine and antioxidants contribute to the better performance and immuno-metabolic status in methionine-supplemented cows.
      Title: Hepatic Activity and Transcription of Betaine-Homocysteine Methyltransferase, Methionine Synthase, and Cystathionine Synthase in Periparturient Dairy Cows Are Altered to Different Extents by Supply of Methionine and Choline.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC179463

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cystathionine beta-synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cysteine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cysteine biosynthetic process from serine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cysteine biosynthetic process via cystathionine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cystathionine beta-synthase
    NP_001095470.1
    XP_010799955.1
    XP_024841382.1
    XP_059737911.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102000.2 → NP_001095470.1  cystathionine beta-synthase

      See identical proteins and their annotated locations for NP_001095470.1

      Status: PROVISIONAL

      Source sequence(s)
      BC151539
      UniProtKB/TrEMBL
      A7MBF8
      Conserved Domains (3) summary
      cd01561
      Location:87 → 385
      CBS_like; CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. ...
      cd04608
      Location:421 → 545
      CBS_pair_PALP_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well ...
      TIGR01137
      Location:78 → 546
      cysta_beta; cystathionine beta-synthase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      143219507..143242399 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024985614.2 → XP_024841382.1  cystathionine beta-synthase isoform X3

      Related
      ENSBTAP00000000184.5, ENSBTAT00000000184.6
      Conserved Domains (1) summary
      TIGR01137
      Location:78 → 560
      cysta_beta; cystathionine beta-synthase

    2. XM_010801653.4 → XP_010799955.1  cystathionine beta-synthase isoform X1

      See identical proteins and their annotated locations for XP_010799955.1

      UniProtKB/TrEMBL
      F1MEW4
      Related
      ENSBTAP00000063539.2, ENSBTAT00000087445.2
      Conserved Domains (3) summary
      cd01561
      Location:87 → 385
      CBS_like; CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. ...
      cd04608
      Location:421 → 545
      CBS_pair_PALP_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well ...
      TIGR01137
      Location:78 → 546
      cysta_beta; cystathionine beta-synthase

    3. XM_059881928.1 → XP_059737911.1  cystathionine beta-synthase isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous